A5005050575- Cell death mechanisms and regulation
- Advanced Proteomics Techniques and Applications
- Protein Kinase Regulation and GTPase Signaling
- Machine Learning in Bioinformatics
- Ubiquitin and proteasome pathways
- Innovations in Medical Education
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Metabolomics and Mass Spectrometry Studies
- Innovative Approaches in Technology and Social Development
- Disability Education and Employment
- RNA and protein synthesis mechanisms
- Enzyme Structure and Function
- MicroRNA in disease regulation
- Cellular transport and secretion
Western University
2014-2023
Post-translational modifications of proteins regulate diverse cellular functions, with mounting evidence suggesting that hierarchical cross-talk between distinct may fine-tune responses. For example, in apoptosis, caspases promote cell death via cleavage key structural and enzymatic some instances is inhibited by phosphorylation near the scissile bond. In this study, we systematically investigated how protein affects susceptibility to caspase using an N-terminomic strategy, namely, a...
microRNA (miRNA) activity and regulation are of increasing interest as new therapeutic targets. Traditional approaches to assess miRNA levels in cells rely on RNA sequencing or quantitative PCR. While useful, these based extraction cannot be applied real-time observe with single-cell resolution. We developed a green fluorescence protein (GFP)-based reporter system that allows for direct, readout changes live cells. The (MiRAR) consists GFP fused 3′ untranslated region containing...
Casein Kinase 2 (CSNK2) is an extremely pleiotropic, ubiquitously expressed protein kinase involved in the regulation of numerous key biological processes. Mapping CSNK2-dependent phosphoproteome necessary for better characterization its fundamental role cellular signalling. While ATP-competitive inhibitors have enabled identification many putative substrates, compounds targeting highly conserved ATP-binding pocket often exhibit off-target effects limiting their utility definitive...
Inclusive education strengthens the capacity of academic systems and addresses needs all learners. Although colleges universities are embracing diversity introducing inclusive principles into higher policies practices, there is scarcity in research exploring undergraduate university students’ participation engagement science laboratories, especially among underrepresented equity-deserving groups. Accordingly, this study explores perspectives on laboratory courses investigates best practices...