A5051358135- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Aortic aneurysm repair treatments
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Infective Endocarditis Diagnosis and Management
- Connective tissue disorders research
- Clinical Nutrition and Gastroenterology
- Renal and Vascular Pathologies
- Congenital Heart Disease Studies
- Peripheral Artery Disease Management
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced Database Systems and Queries
- Sulfur Compounds in Biology
- Semantic Web and Ontologies
- Congenital heart defects research
- Venous Thromboembolism Diagnosis and Management
- Data Management and Algorithms
- Diagnosis and Treatment of Venous Diseases
- Amino Acid Enzymes and Metabolism
Karolinska Institutet
2010-2021
Stockholm South General Hospital
2016-2018
Karolinska University Hospital
2010-2012
Inserm
2010
Thoracic aortic aneurysm (TAA) is a common complication in patients with bicuspid valve (BAV), the most frequent congenital heart disorder. For unknown reasons TAA occurs at younger age, higher frequency BAV than tricuspid (TAV), resulting an increased risk for dissection and rupture. To investigate incidence patients, we obtained tissue biopsy samples from nondilated dilated aortas of 131 TAV patients. Global gene expression profiles were analyzed controls intima-media adventitia (in total...
Objective: There is an ongoing discussion regarding the mechanism of aortic dilatation in bicuspid valve (BAV) disease, that is, this a hemodynamic effect or related to inborn weakness wall? This study evaluated possibility BAV morphology being ascending aorta as such correlation would strengthen idea alterations cause aorta. Methods: The 300 patients admitted for and/or disease was by echocardiography and surgeon's inspection valve. Results: A tricuspid (TAV), BAV, unicuspid (UAV) present...
Abstract Individuals with a bicuspid aortic valve (BAV) are at significantly higher risk of developing complications than individuals tricuspid valves (TAV) and defective signaling during the embryonic development and/or life time exposure to abnormal hemodynamic have been proposed as underlying factors. However, an explanation for molecular mechanisms aortopathy in BAV has not yet provided. We combined proteomics, RNA analyses, immunohistochemistry, electron microscopy identify differences...
Thoracic aortic aneurysm is a common complication in patients with bicuspid valve (BAV). Alternatively spliced extra domain A (EDA) of fibronectin (FN) has an essential role tissue repair. Here we analyze the expression FN spliceforms dilated and nondilated ascending aorta tricuspid (TAV) BAV patients.The mRNA was analyzed by Affymetrix Exon arrays TAV (n=40) (n=69). EDA B (EDB) increased from compared (P<0.001 P<0.05, respectively). In contrast, not (P=0.25), whereas EDB upregulated...
Introduction Aortic valve calcification (AVC) may predict poor outcome. Bicuspid aortic (BAV) leads to several haemodynamic changes accelerating the progress of (AV) disease. Aims To compare diagnostic accuracy transoesophageal echocardiography (TEE) and transthoracic (TTE) in assessment phenotype degree AVC, with intra-operative evaluation as a reference. Methods We examined 169 patients (median age 65 years, 51 women) without significant coronary artery disease undergoing AV and/or root...
Summary Background Evaluation of arterial deformation and mechanics using strain analysis on ultrasound greyscale images has gained increasing scientific interest. The aim this study was to validate in vitro measurements circumferential by velocity vector imaging ( VVI ) speckle‐tracking echocardiography STE against sonomicrometry as a reference method. Method Two polyvinyl alcohol phantoms sized mimic the descending aorta were constructed connected pulsatile flow pump obtain high‐resistance...
Summary Introduction Aortic valve calcification ( AVC ), even without haemodynamic significance, may be prognostically import as an expression of generalized atherosclerosis, but techniques for echocardiographic assessment are essentially unexplored. Methods Two‐dimensional (2 D ) recordings P hilips IE 33) the aortic in short‐axis and long‐axis views were performed 185 consecutive patients within 1 week before surgery stenosis n = 109, AS regurgitation 61, AR their combination 8) or...
The impact of volume overload due to aortic regurgitation (AR) on systolic and diastolic left ventricular (LV) indices atrial remodeling is unclear. We assessed the structural functional effects severe AR LV atrium before after valve replacement.Patients with scheduled for replacement (n = 65) underwent two- three-dimensional echocardiography, including strain imaging, 1 year surgery. A control group was selected, comprised patients undergoing surgery thoracic aneurysm without 20). Logistic...
A bicuspid aortic valve (BAV) is associated with accelerated disease (AVD) and abnormalities in elasticity. We investigated the intima-media thickness of descending aorta (AoIMT) patients AVD or without an ascending aneurysm (AscAA), relation to BAV versus tricuspid (TAV) phenotype, type disease, cardiovascular risk factors, single-nucleotide polymorphisms (SNPs) a known association carotid IMT.368 (210 BAV, 158 TAV,); mean age 64 ± 13 years) were examined using transesophageal...
Summary Background and aims Intima‐media thickness is a marker for atherosclerosis but also influenced by shear stress flow. We evaluated the relation between intima‐media of descending aorta (Ao IMT ) common carotid artery ( CIMT in patients with without severe aortic valve disease sAVD ). Methods A total 310 (233 , 77 without) were examined regard to Ao using transesophageal echocardiography ultrasound, respectively, before valvular and/or surgery. Digitally stored B‐mode images used...
We have developed a system that can process queries to RDF views of large relational databases. This provides very flexible wrapped databases be queried using either RDQL or SQL. Query processing over such is challenging because their naive implementation becomes complex. makes it critical optimize not only data access time but also the perform query optimization itself. techniques based on partial evaluation expressions as way enable execution real-world
Laser Doppler was used to measure toe blood pressure (TBP) in 40 consecutive patients with various degree of peripheral arterial disease. The aim this methodological study increase the usefulness TBP by exploring interchangeability between from first and second investigating daily routine reproducibility measurement variability. According our design values were based on three measurements that averaged. At simultaneous measurements, 71 mm Hg (standard deviation [SD] 25) compared 70 (SD toe....