A5000225161- Pregnancy and preeclampsia studies
- Cancer Genomics and Diagnostics
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- Topic Modeling
- MicroRNA in disease regulation
- Advanced Text Analysis Techniques
- RNA modifications and cancer
- Renal and related cancers
- Genetic Syndromes and Imprinting
- Circular RNAs in diseases
- Pluripotent Stem Cells Research
- Natural Language Processing Techniques
- Reproductive System and Pregnancy
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genetic diversity and population structure
- Cancer Mechanisms and Therapy
- Esophageal Cancer Research and Treatment
- Animal Genetics and Reproduction
- Genetic Mapping and Diversity in Plants and Animals
- Text and Document Classification Technologies
- Privacy-Preserving Technologies in Data
- Kruppel-like factors research
- Tissue Engineering and Regenerative Medicine
- Peptidase Inhibition and Analysis
City of Hope
2025
Beckman Research Institute
2025
Henan University of Science and Technology
2025
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2024
Shandong University of Traditional Chinese Medicine
2024
Bridge University
2023
University of California, Davis
2023
Cornell University
2023
University of Edinburgh
2023
Karolinska Institutet
2023
Previous reports have demonstrated that embryonic stem cells were capable of differentiating into primordial germ through the formation embryoid bodies subsequently generated oocyte-like (OLCs). Such a process could facilitate studies follicle oocyte development in vitro and regenerative medicine. To investigate pluripotency human amniotic fluid (hAFSCs) their ability to differentiate cells, we isolated CD117(+)/CD44(+) hAFSC line showed fibroblastoid morphology intrinsically expressed both...
MicroRNAs (miRNAs) are increasingly seen as important regulators of placental development and opportunistic biomarker targets. Given the difficulty in obtaining samples from early gestation subsequent paucity same, investigation role miRNAs human placenta has been limited. To address this, we generated miRNA profiles using 96 placentas presumed normal pregnancies, across gestation, combination with matched maternal plasma. Placenta range 6 to 23 weeks' a time period that includes early,...
Cloud-to-Vehicle (C2V) integration serves as a fundamental infrastructure to provide robust computing and storage support for Vehicular Social Networks (VSNs). However, the proliferation of sensitive personal data within VSNs poses significant challenges in achieving secure efficient sharing while maintaining usability precise retrieval capabilities. Although existing searchable attribute-based encryption schemes offer encrypted fine-grained access control mechanisms, these still exhibit...
Abstract Background: Plasmablastic multiple myeloma (PMM), a subtype of (MM), is characterized by immature plasma cells in the bone marrow. PMM considered high-risk disease due to its aggressive nature and reduced survival rates. The dramatic epigenetic remodeling that occurs cancer genomes associated with loss silencing at transposable elements. Several consequences this TEs have been documented, from being co-opted genome for gene regulation, process known as ‘onco-exaptation’, instability...
During ovarian development, gonadal ridge epithelial-like (GREL) cells arise from the epithelial of ventral surface mesonephros. They ultimately develop into follicular granulosa or cells. Stromal fibroblasts mesonephros and penetrate ovary. We developed methods for isolating culturing fetal GREL by expansion colonies without passage. In culture, these two cell types were morphologically different. examined expression profile 34 genes qRT-PCR, which 24 had previously been studied in whole...
Bone morphogenetic protein 15 (BMP15) is secreted by the mammalian oocytes and indispensable for ovarian follicular development, ovulation, fertility. To determine regulation mechanism of BMP15 gene, regulatory sequence porcine was investigated in this study. The cloned promoter retains cell-type specificity, activated cells derived from tissue. luciferase assays combination with a series deletion show that −427 to −376 bp region primary element, which there are number transcription factor...
Abstract During early human placental development, extravillous cytotrophoblasts (EVT) invade the uterine vasculature to sequester a maternal blood supply. The impact of this on gene expression has not been established for normal pregnancy. Using RNA sequencing, we profiled chorionic villous tissues from 96 pregnancies at 6-23 weeks gestation. We identified 1,048 genes that were differentially expressed between 6-10 weeks’ and 11-23 These are predominantly enriched in transcription factor...
To explore the expression of Klotho mRNA and protein in placenta macrosomia its relationship with birth weight neonates.The cases were from November 2014 to March 2015 Shengjing Hospital China Medical University, divided into 4 groups: gestational diabetes group (GM), normal (GN), pregnancy (NM) (NN). detected by immunohistochemistry SP method, real-time fluorescent quantitative PCR western blot, respectively, compared among groups.(1) Immunohistochemical detection showed positive rate was...
Abstract Background MicroRNAs (miRNAs) are increasingly seen as important regulators of placental development and opportunistic biomarker targets. Given the difficulty in obtaining samples from early gestation subsequent paucity same, investigation role miRNAs human placenta has been limited. To address this, we generated miRNA profiles using 96 placentas presumed normal pregnancies, across gestation, combination with matched maternal plasma. Placenta range 6–23 weeks’ a time period that...
The human placenta is a rapidly developing transient organ that key to pregnancy success. Early development of the conceptus occurs in low oxygen environment before oxygenated maternal blood begins flow into at ~10-12 weeks' gestation. This process likely substantially affect overall placental gene expression. Transcript variability underlying expression has yet be profiled. In this study, accurate transcript profiles were identified for 84 chorionic villus tissue samples collected across...
Abstract The human placenta is a rapidly developing transient organ that key to pregnancy success. Early development of the conceptus occurs in low oxygen environment before oxygenated maternal blood begins flow into at ∼10-12 weeks’ gestation. This process likely substantially affect overall placental gene expression. Transcript variability underlying expression has yet be profiled. In this study, accurate transcript profiles were identified for 84 chorionic villus tissue samples collected...
Current keyword spotting systems are typically trained with a large amount of pre-defined keywords.Recognizing keywords in an open-vocabulary setting is essential for personalizing smart device interaction.Towards this goal, we propose pure MLP-based neural network that based on MLPMixer -an MLP model architecture effectively replaces the attention mechanism Vision Transformers.We investigate different ways adapting to QbyE task.Comparisons state-of-the-art RNN and CNN models show our method...
e17573 Background: Homologous recombination deficiency(HRD) as a promising biomarker holds predictive and prognostic value in anticancer therapies, especially ovarian cancer. Although next-generation sequencing techniques such whole-exome (WES) targeted have proven to be powerful detection of HRD, the latest low-pass (1x) whole-genome (WGS) with characteristic large-scale patterns for HRD status, cost-effective screening strategy, established feasibility. In this study, we developed...
<title>Abstract</title> Genome-wide association analysis is a powerful tool to identify genomic loci underlying complex traits. However, the application in natural populations comes with challenges, especially power loss due population stratification. Here, we introduce bivariate approach GWAS dataset of Arabidopsis thaliana. We demonstrate efficiency double-phenotype uncover hidden genetic masked by structure via series simulations. In real data analysis, common allele, strongly confounded...
e15511 Background: As one of the most concerning world public health issue, cancer accounted for 21% all deaths. Early detection methods help reduce chance dying from cancer. The fragmentation patterns plasma circulating cell-free DNA (cfDNA) in tumor patients and healthy people are different, which reflects aberrant gene-regulation patients. Measure cfDNA fragmentomics not only identify biomarkers to detect early, but also contribute revealing biological regulatory mechanism In this study,...
e16085 Background: The comprehensive molecular characterization of gastric cancer has been uncovered by Cancer Genome Atlas (TCGA) research work. However, the genomic feature Chinese locally advanced or metastatic seldom reported. This study aims to explore landscape cancer. Methods: 556 patients were enrolled in this and 245 eligible with adequate clinicopathological data analyzed. baseline tumor tissues corresponding blood collected target-captured sequencing applied. Both fragments...
e16040 Background: The combined modality therapy including neoadjuvant chemoradiotherapy has been selected as the standard care for locally advanced Esophageal squamous cell carcinoma (ESCC). However, conclusive evidences to support effectiveness of immunotherapy ESCC are rarely discussed. This study aims investigate molecular features cell-free DNA (cfDNA) and impact their dynamic changes on response in patients. Methods: Twenty-four eligible patients with received were enrolled this study....
e15508 Background: Liquid biopsy has been well known for its potential in cancer detection, non-invasive tumor genotyping and disease surveillance. However, ctDNA levels are low the early stages of monitoring postoperative progression most tumors, which makes detection analysis quite complicated. Methods: In our study, fixed-sequence UMI double-ended sequencing with a 1123-gene panel was used both on blood samples from 200 healthy donors tissue-plasma 1000 colorectal (CRC) patients. First,...
Current keyword spotting systems are typically trained with a large amount of pre-defined keywords. Recognizing keywords in an open-vocabulary setting is essential for personalizing smart device interaction. Towards this goal, we propose pure MLP-based neural network that based on MLPMixer - MLP model architecture effectively replaces the attention mechanism Vision Transformers. We investigate different ways adapting to QbyE task. Comparisons state-of-the-art RNN and CNN models show our...