A5101533368- Surfactants and Colloidal Systems
- nanoparticles nucleation surface interactions
- Neuroscience and Neural Engineering
- Ion channel regulation and function
- Data Management and Algorithms
- Coagulation and Flocculation Studies
- Epigenetics and DNA Methylation
- Crystallization and Solubility Studies
- Microtubule and mitosis dynamics
- Neural dynamics and brain function
- Adsorption, diffusion, and thermodynamic properties of materials
- Planarian Biology and Electrostimulation
- Bayesian Modeling and Causal Inference
- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Esophageal and GI Pathology
- Advanced Clustering Algorithms Research
Novartis (United States)
2021-2025
Shantou University
2023
First Affiliated Hospital of Shantou University Medical College
2023
University at Buffalo, State University of New York
1986-2021
California Institute of Technology
1993
Mutations or silencing of the von Hippel Lindau (VHL) tumor suppressor gene accumulates hypoxia-inducible factors (HIFs). HIF-2α is implicated in oncogenesis ~50% patients with clear cell renal carcinoma (ccRCC) but, has been considered "undruggable". DFF332, an orally administered novel allosteric inhibitor showed dose-dependent antitumor efficacy preclinical models ccRCC. This first-in-human study evaluated safety, tolerability, activity, pharmacokinetics, and pharmacodynamics DFF332...
1. The gating and permeation properties of endogenous stretch‐activated (SA) ion channels in Xenopus oocytes have been studied using the patch‐clamp single channel recording technique. 2. As estimated from probability being open (Po), SA were equally sensitive to suction or pressure. Po was also weakly voltage, increasing with depolarization. Channel activation did not require Ca2+. 3. Kinetic analysis single‐channel records indicated that there are three closed states one state. Among...
<p>Supplementary Figure S1. Time to all grade TRAE at different doses of DFF332. This swimmer plot illustrates the timeline AE onset for each patient in study. The x-axis represents time days, while y-axis lists individual patients. Different colors denote dose level which was allocated, and symbols indicate when adverse events started. AE, event; QD, once daily; QW, weekly; TRAE, treatment-related event.</p>
<p>Key inclusion and exclusion criteria</p>
<div>AbstractPurpose:<p>Mutations or silencing of the von Hippel–Lindau tumor suppressor gene accumulate hypoxia-inducible factors (HIF). HIF-2α is implicated in oncogenesis ∼50% patients with clear-cell renal cell carcinoma (ccRCC) but has been considered “undruggable.” DFF332, an orally administered novel allosteric inhibitor HIF-2α, showed dose-dependent antitumor efficacy preclinical models ccRCC.</p>Patients and Methods:<p>This first-in-human study evaluated...
<p>Supplementary Figure S2. Comparison of percentage changes in patients’ plasma levels erythropoietin between baseline and cycle 3 day 1 (A) with respect to their BOR (B) against the change hemoglobin levels. Statistical comparison was performed using a two-sample t-test; p < 0.05 considered significant. Boxplot (Figure A): central line box, median; interquartile range (IQR; 25th 75th percentile); whiskers, smallest largest values within 1.5 times IQR from lower upper quartiles;...
In systematic reviews and meta-analyses, one is interested in combining information from a variety of sources order to obtain unbiased efficient pooled estimates the mean treatment effect compared control group along with corresponding standard errors confidence intervals, particularly when source data unavailable. However, many studies deviation are not reported lieu other descriptive measures such as median quartiles. this note we provide theoretically optimal best linear estimator (BLUE)...
Double lumen tube (DLT) and single (SLT) are two common endotracheal (ETT) types in esophageal cancer surgery. Evidence of the relationship between ETT postoperative pneumonia (PP) remains unclear. We aimed to determine association (DLT SLT) PP assess perioperative risk-related parameters that affect PP.This study included 680 patients who underwent surgery from January 01, 2010 through December 31, 2020. The primary outcome was PP, secondary PP. independent variable type ETT: DLT or SLT....