A5031484265- vaccines and immunoinformatics approaches
- Computational Drug Discovery Methods
- Antibiotic Resistance in Bacteria
- Machine Learning in Bioinformatics
- Gene Regulatory Network Analysis
- Synthesis and biological activity
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Mosquito-borne diseases and control
- Kruppel-like factors research
- Viral Infections and Vectors
- Bacteriophages and microbial interactions
- Bioinformatics and Genomic Networks
- Hepatitis C virus research
- Monoclonal and Polyclonal Antibodies Research
- Plant Micronutrient Interactions and Effects
- RNA and protein synthesis mechanisms
- Plant Virus Research Studies
- Helicobacter pylori-related gastroenterology studies
- Protein Structure and Dynamics
- RNA modifications and cancer
- Agricultural pest management studies
- Ubiquitin and proteasome pathways
- Enzyme function and inhibition
- Microbial Metabolic Engineering and Bioproduction
National University of Sciences and Technology
2016-2025
University of the Sciences
2012-2022
Government College University, Faisalabad
2022
University of the Punjab
2022
CMH Lahore Medical College and Institute of Dentistry
2021
Army Medical College
2018
National University of Medical Sciences
2018
Acinetobacter baumannii has emerged as a significant nosocomial pathogen during the last few years, exhibiting resistance to almost all major classes of antibiotics. Alternative treatment options such vaccines tend be most promising and cost effective approaches against this resistant pathogen. In current study, we have explored pan-genome A. followed by immune-proteomics reverse vaccinology identify potential core vaccine targets. The available strains (30 complete genomes) is estimated...
Hepatitis C virus (HCV) vaccines, designed to augment specific T-cell responses, have been designated as an important aspect of effective antiviral treatment. However, despite the current satisfactory progress these extensive past efforts largely remained unsuccessful in mediating clinically relevant anti-HCV activity humans. In this study, we used a series immunoinformatics approaches propose multiepitope vaccine against HCV by prioritizing 16 conserved epitopes from three viral proteins...
A series of six novel benzimidazole-pyrazole hybrid molecules was synthesized and characterized using elemental analysis (CHN) spectroscopic methods (1HNMR, FT-IR). All the compounds were evaluated for their in vivo anti ulcerogenic activity Albino rats (weighing 180–220 g). The interactions between active site residues H+/K+ ATPase investigated by molecular docking studies autodock vina 4.0. SCH28080 used to validate results. Also drug likeliness these predicted Molinspiration server light...
The three-dimensional protein structure is pivotal in comprehending biological phenomena. It directly governs function and hence aids drug discovery. development of prediction algorithms, such as AlphaFold2, ESMFold, trRosetta, has given much hope expediting protein-based therapeutic Though no study reported a conclusive application these the efforts continue with optimism. We intended to test algorithms rank-ordering proteins for their instability during pre-translational modification...
Abstract Plants require copper for normal growth and development have evolved an efficient system management based on transport proteins such as P 1B -ATPases, also known heavy metal ATPases ( HMA s). Here, we report HMAs in eleven different Poaceae species, including wheat. Furthermore, the possible role of wheat stress was investigated. BlastP searches identified 27 wheat, phylogenetic analysis Maximum Likelihood method demonstrated a separation into four distinct clades. Conserved motif...
Background The dehydration responsive element-binding (DREB) gene family plays a crucial role as transcription regulators and enhances plant tolerance to abiotic stresses. Although the DREB has been identified characterized in many plants, knowledge about it Solanum tuberosum (Potato) is limited. Results In present study, StDREB was comprehensively analyzed using bioinformatics approaches. We 66 genes through genome wide screening of Potato based on AP2 domain architecture amino acid...
Sepsis is one of the major causes human morbidity and results in a considerable number deaths each year. Lipopolysaccharide-induced sepsis has been associated with TLR4 signalling pathway which collaboration JAK/STAT regulate endotoxemia inflammation. However, during our immune system cannot maintain balance cytokine levels multiple organ damage eventual death. Different opinions have made previous studies about expression patterns role proinflammatory cytokines that attracted attention...
antibiotic resistant infections in high-risk patients are a great challenge for researchers and clinicians worldwide. In an effort to achieve potent bactericidal outcomes, novel chitosan-mastoparan nanoconstruct (Mast-Cs NC) was designed assessed its therapeutic potential through silico, vitro vivo experimentation against clinical multidrug-resistant (MDR)
The diverse pharmacological role of dihydropyrimidinone scaffold has made it to be an interesting drug target. Because the high incidence and mortality rate breast cancer, there is a dire need discovering new pharmacotherapeutic agents in managing this disease. A series twenty-two derivatives 6-(chloromethyl)-4-(4-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (3a-3k) ethyl 6-(chloromethyl)-4-(2-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (4a-4k)...
The hemostatic system prevents and stops bleeding, maintaining circulatory integrity after injury. It directly interacts with the complement system, which is key to innate immunity. In coronavirus disease 2019 (COVID-19), dysregulation of systems has been associated several complications. To understand essential balance between activation regulation these systems, a quantitative immunology model can be established. dynamics components are examined under three distinct conditions: state...
Quinoa is a resilient crop with significant genetic diversity, enabling it to thrive in various climates. This study focuses on the Universal Stress Protein (USP) gene family quinoa. It helps plants maintain homeostasis response drought, high salinity, extreme temperatures, and scavenging reactive oxygen species. The research conducted genome-wide analysis of C. quinoa USP genes (CqUSPs). structure, distribution motifs, phylogenetic history, duplication CqUSPs were analysed. Analysis...
Pancreatic cancer (PaCa) is the seventh most fatal malignancy, with more than 90% mortality rate within first year of diagnosis. Its treatment can be improved identification specific therapeutic targets and their relevant pathways. Therefore, objective this study to identify biomarkers, targets, associated pathways involved in PaCa progression. RNA-seq microarray datasets were obtained from public repositories such as European Bioinformatics Institute (EBI) Gene Expression Omnibus (GEO)...
Abstract Background 2-Aminothiazoles are significant class of organic medicinal compounds utilized as starting material for the synthesis diverse range heterocyclic analogues with promising therapeutic roles antibacterial, antifungal, anti-HIV, antioxidant, antitumor, anthelmintic, anti-inflammatory & analgesic agents. Experimental Eight 1a, 2a–2g were synthesized and characterized by FTIR NMR ( 1 H 13 C). Evaluation antibacterial potential against multi-drug resistant clinical isolates...