A5026397944- Experimental Behavioral Economics Studies
- Blood donation and transfusion practices
- RNA Research and Splicing
- Culture, Economy, and Development Studies
- Decision-Making and Behavioral Economics
- Genomics and Chromatin Dynamics
- Entrepreneurship Studies and Influences
- ICT in Developing Communities
- Human Mobility and Location-Based Analysis
- Sports Analytics and Performance
- Corporate Finance and Governance
- Global Maternal and Child Health
- Infant Development and Preterm Care
- Complex Network Analysis Techniques
- Renal and related cancers
- Trypanosoma species research and implications
- RNA and protein synthesis mechanisms
- Mental Health Research Topics
- Evolutionary Game Theory and Cooperation
- COVID-19 epidemiological studies
- Research on Leishmaniasis Studies
- Ubiquitin and proteasome pathways
- Fungal and yeast genetics research
- Mobile Health and mHealth Applications
- Genetics, Aging, and Longevity in Model Organisms
Novartis (Switzerland)
2018-2024
University of Zurich
2003-2022
Novartis Institutes for BioMedical Research
2018-2021
University of Oxford
2009-2015
University of Bern
2002-2009
Abstract Measuring close proximity interactions between individuals can provide key information on social contacts in human communities and related behaviours. This is even more essential rural settings low- middle-income countries where there a need to understand contact patterns for the implementation of strategies protection interventions. We report quantitative assessment village Malawi, based sensors technology that allows high-resolution measurements contacts. Our results revealed...
Abstract The transcription factor PAX8 is critical for the development of thyroid and urogenital system. Comprehensive genomic screens furthermore indicate an additional oncogenic role in renal ovarian cancers. While a plethora PAX8-regulated genes different contexts have been proposed, we still lack mechanistic understanding how engages molecular complexes to drive disease-relevant transcriptional programs. Here show that protein isoforms originating from MECOM locus form complex with PAX8....
Chemical and antimicrobial effects of paste-like suspensions calcium hydroxide (Ca(OH)2) powder with chlorhexidine (CHx), sodium hypochlorite (NaOCl) or iodine potassium iodide (IPI) solutions were tested compared to conventional Ca(OH)2/saline paste.Equivalent mixtures Ca(OH)2 irrigating paste for their ability raise the pH in root dentine. pastes compacted into prepared canals single-rooted extracted human teeth. Changes over time recorded a microelectrode placed standardized wells within...
Despite the many advantages of Caenorhabditis elegans, biochemical approaches to study tissue-specific gene expression in post-embryonic stages are challenging. Here, we report a novel experimental approach for efficient determination transcriptomes involving rapid release and purification nuclei from major tissues animals by fluorescence-activated sorting (FANS), followed deep sequencing linearly amplified 3′-end regions transcripts (3′-end-seq). We employed these compile transcriptome...
Genes from yeast to mammals are frequently subject non-coding transcription of their antisense strand; however the genome-wide role for remains elusive. As influences chromatin structure, we took a approach assess which features associated with nascent transcription, and contrast these sense transcription. We describe distinct architecture at promoter gene body specifically marked by reduced H2B ubiquitination, H3K36 H3K79 trimethylation increased levels H3 acetylation, remodelling enzymes,...
In yeast, many tandemly arranged genes show peak expression in different phases of the metabolic cycle (YMC) or carbon sources, indicative regulation by a bi-modal switch, but it is not clear how these switches are controlled. Using native elongating transcript analysis (NET-seq), we that transcription itself component switches, facilitating reciprocal gene clusters. HMS2, encoding growth-regulated factor, between sense- antisense-dominant states also coordinate up- and down-regulation at...
Synthesis of ribosomal RNA by polymerase I (RNA pol I) is an elemental biological process and key for cellular homeostasis. In a forward genetic screen in C. elegans designed to identify DNA damage-response factors, we isolated point mutation I, rpoa-2(op259), that leads altered rRNA synthesis concomitant resistance ionizing radiation (IR)-induced germ cell apoptosis. This weak apoptotic IR response could be phenocopied when interfering with other factors ribosome synthesis. Surprisingly,...
Background Multimodal approaches have been shown to be a promising way collect data on child development at high frequency, combining different inputs (from phone surveys signals from noninvasive biomarkers) understand children’s health and outcomes more integrally multiple perspectives. Objective The aim of this work was describe an implementation study using multimodal approach biomarkers, social contact patterns, mobile surveying, face-to-face interviews in order validate technologies...
CLK2 inhibition has been proposed as a potential mechanism to improve autism and neuronal functions in Phelan-McDermid syndrome (PMDS). Herein, the discovery of very potent indazole CLK inhibitor series X-ray structure most analogue are reported. This new was identified through biochemical Caliper assay screen with 30k compounds selected by an silico approach. Novel high-resolution structures all CLKs, including first CLK4 structure, bound known tool (e.g., TG003, CX-4945), also shown yield...
Roughly one quarter of short-term temporary deferrals (STTD) blood donors are low-hemoglobin (LHD), i.e. STTD due to a hemoglobin (Hb) value falling below cutoff 125 g/L for female and 135 male donors. Since voluntarily donating is prosocial activity, may perceive deferral as social exclusion, which can cause pain, decrease self-esteem, lead antisocial behavior. However, little known about the causal impacts LHD on donor return.We conducted quasi-experiment with 80,060 invited drives in...
The current predicted mechanisms that describe RNA polymerase II (pol II) transcription termination downstream of protein expressing genes fail to adequately explain, how premature is prevented in eukaryotes possess operon-like structures. Here we address this issue by analysing at the end single and located within operons nematode Caenorhabditis elegans. By using a combination RT-PCR ChIP analysis found pol generally transcribes up 1 kb past poly(A) sites into 3′ flanking regions before it...
The procyclin genes in Trypanosoma brucei are transcribed by RNA polymerase I as part of 5–10 kb long polycistronic transcription units on chromosomes VI and X. Each locus begins with two followed at least one procyclin-associated gene (PAG) . In procyclic (insect midgut) form trypanosomes, PAG mRNA levels about 100-fold lower than those procyclins. We show that deletion PAG1 , PAG2 or PAG3 results increased from downstream the same unit. Nascent analysis revealed most effects due to...
Spillovers of prosocial motivation are crucial for the formation social capital. They facilitate interactions among individuals and create multipliers that amplify effects policy interventions. We conducted a large-scale intervention study dyads blood donors to investigate whether ties lead motivational spillovers in decision donate. The is randomized phone call making aware current shortage their type serving us as an instrument identifying spillovers. About 40% donor's spills over other...
Abstract Can culture explain persistent differences in economic activity among individuals and across regions? A novel measure of cultural origin enables us to contrast entrepreneurial located the same municipality, but whose ancestors lived just on opposite sides Swiss language border eighteenth century. Individuals with ancestry from German-speaking side create 20% more firms than those French-speaking side. These persist over generations independent predominant at current location. Yet,...
Thirteen glucose analogues bearing electrophilic groups were synthesized (five of them for the first time) and screened as inhibitors transporter (EII Glc ) Escherichia coli phospho enol pyruvate–sugar phosphotransferase system (PTS). 2′,3′‐Epoxypropyl β‐ d ‐glucopyranoside ( 3a is an inhibitor also a pseudosubstrate. Five are nonvectorial phosphorylation by EII but not pseudosubstrates. They selective demonstrated comparison with Man , another Glc‐specific structurally different...
Persistent differences in entrepreneurial activity between regions and countries remain unexplained. This paper argues that cultural heritage is an important determinant. We exploit a quasi-experimental setting comparing activities of individuals with different ancestry from within Switzerland but who live the same municipality today are hence exposed to economic institutional environment. find origin on German-speaking side Swiss language border found 20% more firms than their counterparts...
Persistent differences in entrepreneurial activity between regions and countries remain unexplained. This paper argues that cultural heritage is an important determinant. We exploit a quasi-experimental setting comparing activities of individuals with different ancestry from within Switzerland but who live the same municipality today are hence exposed to economic institutional environment. find origin on German-speaking side Swiss language border found 20% more firms than their counterparts...
In Malawi, only 5% of parents state that the right age for a woman to marry is below 18, but 42% girls get married before they reach legal age. We document social image concerns are likely an important mechanism behind wedge: where prevalence child marriage high, those who do not off their under-age daughters perceived as less altruistic, reciprocal and trustworthy than do. then randomly assign 412 villages public donation drive, through which participants could donate maize be redistributed...
Summary BTB and CNC homolog 1 (BACH1) is a master transcriptional regulator of the cellular oxidative stress response pro-metastatic oncogene. Post-translational stability BACH1 tightly regulated by distinct F-box ubiquitin ligases, including SCF FBXO22 FBXL17 . However, molecular details have been elusive. Here, we reveal structural switch in that controls recognition three-dimensional degron domain, thus explaining its specificity for dimeric BACH1. We describe how cancer-associated...