A5038249382- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Metabolism, Diabetes, and Cancer
- Cancer-related gene regulation
- Maternal and fetal healthcare
- Maternal and Perinatal Health Interventions
- Sirtuins and Resveratrol in Medicine
- Low-power high-performance VLSI design
- Quantum Computing Algorithms and Architecture
- Grief, Bereavement, and Mental Health
- Calcium signaling and nucleotide metabolism
- Genomics and Chromatin Dynamics
- Cellular transport and secretion
- RNA modifications and cancer
- Advancements in Semiconductor Devices and Circuit Design
- Gestational Diabetes Research and Management
Max Planck Institute for Biology of Ageing
2019-2024
University of Arizona
2023-2024
Center for Integrated Protein Science Munich
2018-2020
Ludwig-Maximilians-Universität München
2018-2020
Tata Institute of Fundamental Research
2019
Abstract Genome-wide DNA demethylation is a unique feature of mammalian development and naïve pluripotent stem cells. Here, we describe recently evolved pathway in which global hypomethylation achieved by the coupling active passive demethylation. TET activity required, albeit indirectly, for demethylation, mostly occurs at sites devoid binding. Instead, TET-mediated locus-specific necessary activating subset genes, including pluripotency germline marker Dppa3 ( Stella, Pgc7 ). DPPA3 turn...
Anabolic and catabolic signaling mediated via mTOR AMPK (AMP-activated kinase) have to be intrinsically coupled mitochondrial functions for maintaining homeostasis mitigate cellular/organismal stress. Although glutamine is known activate mTOR, whether how differential utilization of impinges on has been less explored. Mitochondrial SIRT4, which unlike other sirtuins induced in a fed state, inhibit signaling/pathways through the AMPK-PGC1α/SIRT1–peroxisome proliferator-activated receptor α...
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20453-0
Since, the scale of integration keeps on growing more and signal processing applications need to be implemented Very Large Scale Integrated chip. These demand great computational capacity along with a considerable amount energy. The objective this paper is provide promising low power solution for multiplier design Integration. focus reduction dissipation which showing an ever-increasing growth scaling down techniques. primarily throws light using Radix-4 modified booth's algorithm Split...
Abstract Genome-wide DNA demethylation is a unique feature of mammalian development and naïve pluripotent stem cells. So far, it was unclear how mammals specifically achieve global hypomethylation, given the high conservation (de-)methylation machinery among vertebrates. We found that requires TET activity but mostly occurs at sites where proteins are not bound suggesting rather indirect mechanism. Among few specific genes activated by pluripotency germline marker Dppa3 ( Pgc7, Stella ),...
Introduction Incidents of maternal morbidity and mortality (MMM) continue to rise in the USA. Significant racial ethnic health inequities exist, with Native American (NA) women being three four times more likely die than white, non-Hispanic women, five experience an incident severe morbidity. Few studies have identified individual community-level risk factors MMM experienced by NA women. Therefore, this systematic review will identify said Methods analysis This be conducted according...
Abstract Anabolic and catabolic signalling mediated via mTOR AMPK have to be intrinsically coupled mitochondrial functions for maintaining homeostasis mitigate cellular/organismal stress. Although, glutamine is known activate mTOR, if/how differential utilization of impinges on less explored. Mitochondrial SIRT4, which unlike other sirtuins induced in a fed state, inhibit signalling/pathways through AMPK-PGC1a/SIRT1-PPARa axis negatively regulate metabolism TCA cycle. However, physiological...