The COVID-19 pandemic has imposed a wide variety of unprecedented challenges, many which appear to be disproportionately affecting the mental health and well-being young adults. While there is evidence suggest university students experience high rates disorders, less known about specific impacts on student how they are coping with this stress. To address gap, we conducted an online study among undergraduate ( n = 366) examine impact academics, social isolation, health, as well extent have...

This study sought to examine if mental health issues, namely depression and anxiety symptoms, loneliness were experienced differently according various demographic groups during the COVID-19 pandemic (i.e., a societal stressor). An online survey, comprising questions questionnaires on depression, was distributed in Canada height of social distancing restrictions pandemic. Respondents (N=661) from lower income households greater anxiety, loneliness. Specifically, those with an annual...

Several prosocial behaviors may be influenced by the hormone oxytocin. In line with this perspective, oxytocin receptor (OXTR) gene single nucleotide polymorphism (SNP), rs53576, has been associated a broad range of social behaviors. regard, G allele OXTR SNP accompanied beneficial attributes such as increased empathy, optimism, and trust. current study among university students (N = 288), it was shown that early-life maltreatment depressive symptoms, genotype moderated relationship, under...

Stress responses in humans can be attenuated by exogenous oxytocin administration, and these stress-buffering properties may moderated social factors. Yet, the influence of acute stressors on circulating endogenous levels have been inconsistent, limited information is available concerning support moderating this relationship. In current investigation, undergraduate women (N = 67) were assessed Trier Social Test (TSST) with either from a close female friend or no being available. An...

Beta-amyloid (Aβ) oligomers contribute to the pathophysiology of Alzheimer disease (AD), and metabotropic glutamate receptor 5 (mGluR5) has been shown act as a for both Aβ cellular prion proteins. Furthermore, genetic deletion mGluR5 in an APPswe/PS1ΔE9 mouse model AD improves cognitive function reduces plaques oligomer concentrations. Here, we show that chronic administration orally bioavailable mGluR5-selective negative allosteric modulator CTEP, which is similar structure, potency,...

Perceived discrimination has consistently been shown to be associated with diminished mental health, but the psychological processes underlying this link are less well understood. The present series of four studies assessed role a history traumatic events in generating proliferation stressors and threat appraisals, which turn predict distress (depressive posttraumatic stress symptoms) (mediation model), or whether prior sensitize group members, such that when they encounter discrimination,...

Emerging adults, including post-secondary education students, are disproportionately affected by the social and economic impacts of COVID-19 pandemic. The speed with which society moved in attempt to minimize spread virus left many students uncertainty concern about their health, mental academic futures. Considering that a population at risk, it is important determine how respond face pandemic, what coping mechanisms or supports will result improved health outcomes. This knowledge be helpful...

Suicide rates among Indigenous peoples in Canada are at least twice that of their non-Indigenous counterparts. Although contemporary stressors contribute to this increased risk, historical experiences such as the Indian Residential School (IRS) system may also have continuing links with risk for suicidal thoughts and behaviors. The current investigation examined intergenerational cumulative between familial IRS attendance relation lifetime suicide ideation attempts First Nations adults...

A single-nucleotide polymorphism on the oxytocin receptor gene (OXTR), rs53576, involving a guanine (G) to adenine (A) substitution has been associated with altered prosocial features. Specifically, individuals GG genotype (i.e. absence of polymorphism) display beneficial traits including enhanced trust, empathy and self-esteem. However, because G carriers might also be more socially sensitive, this may render them vulnerable adverse effects negative social stressor. The current...

Introduction Undergraduate university students experienced many academic and non-academic stressors during the first year of coronavirus (COVID-19) pandemic, putting them at a greater risk negative mental health outcomes. Reports worldwide have shown high incidences depressive, anxiety, stress scores among beginning pandemic. Emerging evidence also suggests that to cope with loneliness youth young adults increased amount time they spent on social media platforms. Methods participated in an...

Stressful events promote several neuroendocrine and neurotransmitter changes that might contribute to the provocation of psychological physical pathologies. Perhaps, because its apparent ecological validity simple application, there has been increasing use social defeat (resident-intruder) paradigms as a stressor. The frequency stress-related psychopathology is much greater in females than males, but typical resident-intruder paradigm less useful assessing stressor effects females. An...

Housing rodents in an enriched environment (EE) has been typically considered to have positive effects on well-being and cognitive functioning of the animals. However, some strains mice, EEs also reported elicit aggression promote stress-related outcomes. In current investigation, we examined whether environmental enrichment would among CD-1 male mice thus sensitize responses a subsequent mild stressor. It was first observed that housed EE for 2 weeks displayed more aggressive behaviors than...

Recent studies have suggested that cortical astroglia play an important role in depressive-like behaviors. Potential astroglial contributions been proposed based on their known neuroplastic functions, such as glutamate recycling and synaptic plasticity. However, the specific mechanisms by which cells may contribute or protect against a depressive phenotype remain unknown. To delineate changes accompany behavior, we used astroglial-specific bacTRAP mice exposed to chronic variable stress...

Environmental enrichment is typically associated with enhanced well-being, improved cognitive function, and stress resilience. However, in some instances grouping adult male mice enriched conditions promoted a stressful environment, which resulted elevated endocrine, monoamine, inflammatory outcomes response to subsequent stressor exposure. The current investigation examined whether raising an environment would modulate social anxiety-like behaviors early adulthood influence brain expression...

Although the neuropeptide oxytocin has been associated with enhanced prosocial behaviors, it also linked to aggression and mental health disorders. Thus, was suggested that might act by increasing salience of social stimuli, irrespective whether these are positive or negative, thus vulnerability negative outcomes. The current study (N = 243), conducted among white university students, examined relation trauma, depressive symptoms including suicidal ideation in a single nucleotide...

Abstract Considering the burden of depression and lack efficacy available treatments, there is a need for biomarkers to predict tailored or personalized treatments. However, identifying reliable has been challenging, likely owing vast symptom heterogeneity high rates comorbidity that exists. Examining map onto dimensions as well shared symptoms/constructs cut across disorders could be most effective informing treatment approaches. With sample 539 young adults, we conducted principal...

Social defeat in mice is a potent stressor that promotes the development of depressive- and anxiety-like behaviours, as well variations neuroendocrine brain neurotransmitter activity. Although environmental enrichment may protect against some adverse behavioural biological effects social defeat, it seems that, among male group-housed maintained an enriched environment (EE), aggressive behaviours be more readily instigated, thus promoting distress exacerbating psychopathological features....

Oxytocin is a hormone that thought to influence prosocial behaviors and may be important in modulating responses both positive negative social interactions. Indeed, single nucleotide polymorphism, rs53576, of the oxytocin receptor gene (OXTR) has been associated with decreased trust, empathy, optimism, support seeking, which are components coping stressors. In current study, conducted among undergraduate students (N = 225), it was shown parental peer related fewer depressive symptoms through...

Abstract Background The period following discharge from a psychiatric inpatient admission is high risk time for suicidal behaviors and death by suicide up to 200 times the global rate. Leveraging electronic health record (EHR) data in concert with machine learning techniques may help predict post attempts (SA) as well modifiable factors that be targeted during an stay order reduce risk. Objectives primary objective of this project was leverage thirteen years EHR admissions Ontario Canada...