A5087121256- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Immune Response and Inflammation
- Renal function and acid-base balance
- Leprosy Research and Treatment
- Menstrual Health and Disorders
- Hematological disorders and diagnostics
- Sodium Intake and Health
- interferon and immune responses
- Inflammatory Bowel Disease
- Mycobacterium research and diagnosis
- NF-κB Signaling Pathways
- Tryptophan and brain disorders
- Infectious Diseases and Tuberculosis
The Ohio State University
2025
Biocon (India)
2016
Bristol-Myers Squibb (India)
2016
Bristol-Myers Squibb (Germany)
2014
B. J. Medical College & Sassoon Hospital
1992
The serine/threonine kinase IL-1R-associated (IRAK)4 is a critical regulator of innate immunity. We have identified BMS-986126, potent, highly selective inhibitor IRAK4 activity that demonstrates equipotent against multiple MyD88-dependent responses both in vitro and vivo. BMS-986126 failed to inhibit assays downstream MyD88-independent receptors, including the TNF receptor TLR3. Very little was seen TLR4, which can also activate an pathway. In mice, compound inhibited cytokine production...
Millions of people take hormonal contraceptives (HCs), often starting during adolescence when ovarian hormones influence brain and behavioral maturation. However, there is a fundamental lack information about the neurobehavioral consequences alterations via adolescent HC use. To begin addressing this gap, we validated rodent model administration characterized its impact on endocrine, transcriptional, endpoints. Cohorts intact post-pubertal female Sprague-Dawley rats received daily...
Abstract There are circadian rhythms for urinary excretion of Na∗ and K+ in hypertensive patients. In the present study, changes electrolyte pattern daily as a function time drug administration have been investigated after separate 3 diuretics at 8 A.M., 2 P.M. A dissociation between natriuretic kaliuretic effects was observed. Natriuresis maximum when hydrochlorothiazide furosemide were administered morning, while potassium sparing effect spironolactone greater following its afternoon....