Claire Elstob
A5068701266- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- COVID-19 epidemiological studies
- Chronic Lymphocytic Leukemia Research
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- Immunodeficiency and Autoimmune Disorders
- Effects of Radiation Exposure
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- Vaccine Coverage and Hesitancy
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- SARS-CoV-2 detection and testing
- Cancer-related Molecular Pathways
- Protein Degradation and Inhibitors
- Salmonella and Campylobacter epidemiology
- Galectins and Cancer Biology
- Lymphoma Diagnosis and Treatment
- Escherichia coli research studies
- Viral gastroenteritis research and epidemiology
- Cell death mechanisms and regulation
Northumbria University
2023
Newcastle University
2014-2022
// Fiona K. Middleton 1 , Miranda J. Patterson Claire Elstob Sarah Fordham Ashleigh Herriott Mark A. Wade Aiste McCormick Richard Edmondson Felicity E.B. May James M. Allan John R. Pollard 2 and Nicola Curtin Newcastle University, Northern Institute for Cancer Research, upon Tyne, UK Vertex Pharmaceuticals (Europe) Limited, Milton Park, Abingdon, Oxfordshire, Correspondence to: Curtin, email: Keywords : ATR, p53, DNA damage response, DNA-PKcs, synthetic lethality Received April 07, 2015...
Ionising radiation is a potent human carcinogen. Epidemiological studies have shown that adolescent and young women are at increased risk of developing breast cancer following exposure to ionising compared with older women, dose-dependent. Although it well understood which individuals radiation-induced carcinogenesis, the molecular genetic mechanisms underlie cell transformation less clear. To identify alterations potentially responsible for driving radiogenic transformation, we exposed...
In this study, we evaluated the impact of viral variant, in addition to other variables, on within-host burden, by analysing cycle threshold (Ct) values derived from nose and throat swabs, collected as part UK COVID-19 Infection Survey. Because burden distributions determined community survey data can be biased due variant epidemiology time-since-infection samples, developed a method explicitly adjust observed Ct value account for expected bias. By adjusted using partial least squares...
Abstract Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognostication. Pooling data from seven studies incorporating 842 cases identifies two genomic locations associated time diagnosis treatment, including 10q26.13 (rs736456, hazard ratio (HR) = 1.78, 95% confidence interval (CI) 1.47–2.15; P 2.71 × 10 −9 ) 6p (rs3778076,...
Precision medicine can significantly improve outcomes for patients with cancer, but implementation requires comprehensive characterization of tumor cells to identify therapeutically exploitable vulnerabilities. Here, we describe somatic biallelic TET2 mutations in an elderly patient acute myeloid leukemia (AML) that was chemoresistant anthracycline and cytarabine acutely sensitive 5'-azacitidine (5'-Aza) hypomethylating monotherapy, resulting long-term morphological remission. Given the role...
Abstract Precision medicine can significantly improve outcomes for cancer patients, but implementation requires comprehensive characterization of tumor cells to identify therapeutically exploitable vulnerabilities. Here we describe somatic biallelic TET2 mutation (focal deletion and nonsense mutation) in an elderly patient with acute myeloid leukemia (AML) that was chemoresistant anthracycline cytarabine, acutely sensitive 5’-azacitidine (5’-Aza) hypomethylating monotherapy, resulting...
Abstract Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we performed meta-analysis of three genome-wide association studies, replication in fourth study, incorporating total 4018 AML cases and 10488 controls. We identified significant risk locus for at 11q13.2 (rs4930561; P = 2.15 × 10 -8 ; KMT5B ). also the cytogenetically normal sub-group (N=1287) 6p21.32 (rs3916765; 1.51 -10 HLA Our results inform on etiology by identifying putative...