A5087775563- Essential Oils and Antimicrobial Activity
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Phytochemicals and Medicinal Plants
- Drug-Induced Hepatotoxicity and Protection
- Psidium guajava Extracts and Applications
- Wound Healing and Treatments
- Mangiferin and Mango Extracts
- Medicinal Plants and Neuroprotection
- Nanoparticles: synthesis and applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytochemical compounds biological activities
- Phytochemistry and biological activities of Ficus species
- Silk-based biomaterials and applications
- Ethnobotanical and Medicinal Plants Studies
- Plant chemical constituents analysis
- Medicinal Plant Research
- Bee Products Chemical Analysis
- Pharmacological Effects of Natural Compounds
- Electrospun Nanofibers in Biomedical Applications
- Bioactive Compounds and Antitumor Agents
- Chemotherapy-induced organ toxicity mitigation
- Food Science and Nutritional Studies
Ain Shams University
2016-2025
Pharmac
2024
Fabrication of Syzygium cumini -loaded polymeric nanofibers for wound healing applications.
Abstract Quercetin is the most common polyphenolic flavonoid present in fruits and vegetables demonstrating versatile health‐promoting effects. This study aimed to examine effects of quercetin (QR) sclareol (SCL) on thiopental sodium (TS)‐induced sleeping forced swimming test (FST) mouse models. SCL (1, 5, 10 mg/kg, p.o .) or QR (50 p.o.) and/or diazepam (DZP) (3 i.p.) were employed. After 30 min TS induction, individual combined animals checked. In FST test, subjected after administration...
The vast socio-economic impact of Alzheimer's disease (AD) has prompted the search for new neuroprotective agents with good tolerability and safety profile. With its outstanding role as antioxidant anti-inflammatory, alongside anti-acetylcholinesterase activity, artichoke can be implemented in a multi-targeted approach AD therapy. Moreover, agricultural wastes represent according to current United Nations Sustainable Development goals an opportunity produce medicinally valuable phenolic-rich...
Hepatic encephalopathy (HE) is a deterioration of brain function in patients suffering from chronic liver disease, cirrhosis as result elevated blood ammonia and the production pseudo-neurotransmitters. Herein, we investigated chemical composition hexane extract Origanum vulgare (O. vulgare) leaves well its possible protective effects against thioacetamide (TAA)-induced HE rats. GC-MS analysis revealed tentative identification twenty-five compounds (82.93%), predominated by cholesten-3-one...
A new xanthone glycoside, 1,3,5,6-tetrahydroxyxanthone-C-4-β-d-glucopyranoside was isolated from the methanol extract of Mangifera indica leaves (Anacardiaceae) growing in Egypt. The structure clarified by 1D and 2D-NMR spectroscopic data. physicochemical properties compound such as lipophilicity, solubility, formulation considerations were predicted via silico ADMET technique using SwissADME server. This provided Lipinski’s rule five, GIT absorption, distribution, metabolism, skin...
Fraxinus xanthoxyloides is a perennial shrub belonging to family Oleaceae, traditionally used for malaria, jaundice, pneumonia, inflammation, and rheumatism. Our study aimed assess the total phenolics (TPC), flavonoids (TFC), terpenoids contents (TTC) antioxidant profiling of F. methanol bark extract (FXBM) its fractions, hexane, chloroform, ethyl acetate aqueous, along with high-performance liquid chromatography diode-array detection (HPLC-DAD). Further, pulmonary protective potential was...
Callistemon is an aromatic genus of flowering plants belonging to family Myrtaceae. The essential oils C. subulatus leaves were collected in four seasons and analyzed using GC/MS. demonstrated monoterpenes as the predominant class. Eucalyptol was main component all seasons; summer (66.87%), autumn (58.33%), winter (46.74%) spring (44.63%), followed by α-pinene; (31.41%), (28.69%), (26.34%) (24.68%). Winter oil, highest yield (0.53 mL/100g), further investigated for its inhibitory activity...
Trypanosomiasis is a protozoan disease transmitted via
Introduction: D-pinitol, a naturally occurring inositol, has diverse biological activities like antioxidant, antimicrobial and anticancer activities. This study aimed to evaluate anti-inflammatory effect of d-pinitol in chick model. Additionally, silico studies were performed the molecular interactions with cyclooxygenase-2 (COX-2). Methods: The tested groups received (12.5, 25, 50 mg/kg) standard drugs celecoxib ketoprofen (42 via oral gavage prior formalin injection. Then, number licks was...
Syzygium cumini (Pomposia) is a well-known aromatic plant belonging to the family Myrtaceae, and has been reported for its various traditional pharmacological potentials, such as antioxidant, antimicrobial, anti-inflammatory, antidiarrheal properties. The chemical composition of leaf essential oil via gas chromatography-mass spectrometry (GC/MS) analysis revealed identification fifty-three compounds representing about 91.22% total oil. identified was predominated by α-pinene (21.09%),...
Background: Cyclophosphamide (CYP) is a chemotherapy drug widely used in the treatment of several types cancers and autoimmune disorders. Unfortunately, it causes severe side effects on many organs due to its oxidative stress effect. Objective: The present study aims tentatively identify phytochemical constituents orange fruit (Citrus sinensis) peel extract (OFPE) elucidate chemopreventive OFPE CYP induced organ toxicity. Methods: high performance liquid chromatography coupled with mass...
Schinus polygamus (Anacardiaceae) is a shrub cultivated in Egypt for ornamental purpose. The major components of bark oil were dl-limonene (29.74%), followed by myrtenal (14.02%) and caryophyllene oxide (11.34%), while E-caryophyllene (55.86%), (27.71%) β-pinene (3.54%) predominant the leaf oil. These isolated oils screened their antimicrobial activity against Staphylococcus aureus ATCC 33591, 29213, Escherichia coli 25922, Pseudomonas aeruginosa 10145, Candida albicans MTCC183 Aspergillus...
Quercetin is a potent cancer therapeutic agent present in fruits and vegetables. The pharmaceutical uses of quercetin are limited due to many problems associated with low solubility, bioavailability, permeability, instability. In addition, the high doses show toxic effects clinical experimental studies. Therefore, new strategy warranted overcome these without use doses. iron oxide nanoparticles can be used as drug delivery system. This study aimed prepare quercetin-conjugated magnetite...
This study aimed to investigate the chemical composition of essential oils isolated from Acca sellowiana (feijoa) leaves and stems elaborate on their relevance as natural anti-aging, coupled with molecular-docking studies. The were analysed using gas chromatography-mass spectrometry analysis investigated for inhibitory effects against acetylcholinesterase, β-secretase, collagenase, elastase tyrosinase. Molecular-modelling was performed MOE-Dock program evaluate binding interactions major...
Syzygium cumini L. is an evergreen tree belonging to family Myrtaceae, employed for different traditional uses like diabetes, inflammation, and fever. The current study aimed compare the chemical compositions of essential oils (EOs) isolated from organs (leaves (Scl), fruits (Scf), seeds (Scs), bark (Scb)) using a GC/MS analysis. Also, chemometric analysis was applied explore main similarities differences among Principal Component Analysis (PCA) hierarchal cluster (HCA). Furthermore, in...