A5075006316- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Ubiquitin and proteasome pathways
Inserm
2022
Centre de Recherche en Cancérologie de Marseille
2022
Centre National de la Recherche Scientifique
2022
Aix-Marseille Université
2021
Cancer Research Center
2021
X-chromosome inactivation (XCI) is triggered by up-regulation of XIST, which coats the chromosome in cis and promotes recruitment chromatin modifiers that transform X into a silent heterochromatic domain. Whether XIST plays role beyond initiation XCI unclear. Here, we demonstrate loss impairs differentiation human mammary stem cells (MaSC) and, upon oncogenic transformation, emergence highly metastatic carcinomas. On Xi, XIST-deficient MaSC display epigenetic erosion reactivation genes...