Huntington's Disease (HD) is an autosomal dominant progressive neurodegenerative disorder characterized by cognitive, behavioral and motor dysfunctions. HD caused a CAG repeat expansion in exon 1 of the gene that translated into expanded polyglutamine tract encoded protein, huntingtin (HTT). While most significant neuropathology occurs striatum, other brain regions are also affected play important role pathology. To date there no cure for HD, recently strategies aiming at silencing HTT...

Nucleic acids exist in a dynamic equilibrium with number of molecules that constantly interact them and regulate the cellular activities. The inherent nature structure conformational integrity these macromolecules can lead to altered biological activity through proper targeting nucleic binding ligands or drug molecules. We studied interaction naturally occurring methylxanthines such as theophylline, theobromine caffeine DNA, using UV absorption Fourier transform infrared (FTIR) spectroscopic...

Resveratrol (RES) and genistein (GEN) are the dietary natural products known to possess chemopreventive property also ability repair DNA damage induced by mutagens/carcinogens. It is believed that therapeutic activity of these compounds could be primarily due their interaction with nucleic acids but detailed reports not available. We here explore drugs considering RNA as a potential target. The RES GEN has been analysed in buffered solution [saline sodium citrate (SSC)] [tris ethylene...

We evaluated the impact of early embryonic deletion huntingtin (htt) from pyramidal neurons on cortical development, neuron survival and motor behavior, using a cre-loxP strategy to inactivate mouse htt gene (Hdh) in emx1-expressing cell lineages. Western blot confirmed substantial reduction cerebral cortex these Emx-httKO mice, with residual all likelihood restricted interneurons subpallial lineage and/or vascular endothelial cells. Despite loss lamination was normal, as revealed by...

Abstract Time Correlated Single Photon Counting (TCSPC) was used for the first time to analyze effect/changes in mode of intercalation ethidium bromide (EtBr) and acridine orange (AO) calf thymus DNA brought about due interaction naturally occurring methylx-anthines such as theophylline (X1), theobromine (X2) caffeine (X3). UV absorption fluorescence studies were also carried observe behaviour these xanthines on modulation binding anticancer agents (cisplatin, novantrone, actinomycin D)...

We investigated the genome-wide consequences of pan-histone deacetylase inhibitors (HDACIs) trichostatin A (TSA) and m-carboxycinnamic acid bis-hydroxamide (CBHA) in hearts BALB/c mice eliciting hypertrophy response to interleukin-18 (IL-18). Both TSA CBHA profoundly altered cardiac chromatin structure that occurred concomitantly with normalization IL-18-induced gene expression amelioration hypertrophy. The exposed IL-18+/-TSA or elicited distinct profiles. Of 184 genes were differentially...

Abstract The binding of naturally occurring methylxanthines such as theophylline, theobromine and caffeine to nucleic acids are reckoned be pivotal they able modulate the cellular activities. We explore interaction yeast RNA efficacy above xanthine derivatives by using UV absorption differential spectroscopy Fourier Transform Infrared (FTIR) spectroscopy. Both analyses show discrimination in their affinity RNA. UV-spectrum at P/D 3.3 reveals greater activity for theophylline (85 ± 5%),...

(2001). From RNA world to Protein: An eagle's eye view of the Role Guanosine in Tracing Antiquity Intron. Journal Biomolecular Structure and Dynamics: Vol. 18, No. 5, pp. 709-712.

Abstract The increasing incidence of pathogens and drug resistance has become major threat in the current arena. Hence, there is a need for development alternative therapeutic target to combat increase problem other than cell membrane. Besides DNA, recently RNA been recognized as central site design. Group I intron unique class molecule that undergoes self-catalytic activity due its folded structure catalyze number cellular reactions. Recently, vitro studies have shown group could be...

Research Article| February 01 1972 Pullulanase synthesis in Klebsiella (aerobacter) aerogenes A C R Dean; Dean 1Physical Chemistry Laboratory, University of Oxford, Oxford OXI 3QZ, U.K. Search for other works by this author on: This Site PubMed Google Scholar S Gray; Gray G Hope; Hope I M Johnson Biochem J (1972) 126 (3): 15P–16P. https://doi.org/10.1042/bj1260015Pb Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Twitter LinkedIn Cite Get...

Sjögren-Larsson syndrome (SLS) is a rare autosomal recessive disorder characterized by scaling skin (ichthyosis), mental retardation, and spasticity. SLS caused mutations in the ALDH3A2 gene, which encodes fatty aldehyde dehydrogenase (FALDH), an enzyme that involved oxidation of alcohol. In SLS, FALDH deficiency impaired results lipid accumulation, responsible for symptoms. Spurred previous hematopoietic stem cell gene therapy trials multi-systemic diseases, such as Adrenoleukodystrophy...

Sickle cell disease (SCD) and thalassemia are very severe inherited disorders of the red amongst world's most common genetic diseases. Thalassemia is caused by a serious lack normal β-globin production in cells whereas, sickle reflects mutant hemoglobin that produces protein aggregates. The fetal-globin (HbF) may compensate for reduction also it functions to inhibit sickling participating formation mixed tetramers including both γ βS chain. Thus induction HbF holds tremendous promise...