The checkpoint inhibitor therapy that blocks programmed death-1 (PD-1) and its major ligand PD-L1 has achieved encouraging clinical efficacy in certain cancers. However, the binding of inhibitors with other immune cells express often results a low response rate to blockade severe adverse effects. Herein, an LyP1 polypeptide-modified outer-membrane vesicle (LOMV) loaded PD-1 plasmid is developed achieve self-blockade tumor cells. nanocarriers accumulate tissue through OMV-targeting ability...

As a flexible and reliable way for distributed energy consumption integration, the converters-dominated microgrid has attracted more attention recently. Owing to low inertia high nonlinearity of power converters, islanded under large-signal disturbances is easily suffer transient stability problems. To support stable operation microgrid, grid-forming converters are extensively investigated applied. In this paper, an improved equal area criterion (IEAC) proposed analysis simple equipped with...

Abstract Alveolar bone resorption is a major cause of teeth loss and jeopardizes the osseointegration dental implants, greatly affecting patient's quality life health. It still great challenge to completely regenerate alveolar defect through traditional guided regeneration (GBR) membranes due their limited bioactivity potential. Herein, new hierarchical‐structured mineralized nanofiber (HMF) scaffold, which combined with both anisotropic isotropic nanofibrous surface topography particles,...

With the increasing penetration of renewable energy generators, stability issues grid-tied converter systems become much more important. However, due to high nonlinearity and varying damping systems, conventional transient analysis methods are not applicable, which may bring conservativeness or misjudgment on assessment. In this paper, with is investigated provide boundary estimation. Firstly, considering frequency mutation phase-locked loop (PLL) caused by various perturbations, a modified...

How to precisely reprogram tumor-associated macrophages (TAMs) and combine them with immunogenic cell death (ICD) is still a great challenge in enhancing the antitumor immunotherapeutic effect. Here, we developed localized drug delivery system step-by-step internalization ability based on hierarchical-structured fiber device. The chemotherapeutic agent-loaded nanomicelles are encapsulated internal chambers of fiber, which could first be internalized by actively targeting tumor cells induce...

With the rapid development of distributed renewable energy generation and integration, stability issues power converters systems have been widely studied in recent years. Many previous studies focus on transient a single converter connected to weak grid. However, nonlinear dynamics mechanism multiple remain unclear. In this article, unified model paralleled-converters system is established, which reveals interactive damping among To analyze impacts terms stability, dual-iterative equal area...

Microgrid has been rapidly developed for the integration of distributed renewable energy, owing to their superiority flexible operation and high reliability. Without frequency support from main grid, microgrid under islanded operating mode is more likely lose stability in presence large-signal disturbances. However, previous studies mainly focus on weak grid conditions ignore interaction effects between different-type converters. Therefore, this article investigates transient synchronization...

The power electronics' penetration in modern grids is rapidly increasing due to the growing proportion of renewable energy generation. As important conversion interface, stable operation grid-tied converters vital overall safe double-high system. prior arts have mainly focused on varying negative damping phase-locked loop (PLL). Negative imposes into system and detrimental system's transient stability should not be neglected as constant positive synchronous generators. deficiencies previous...

The transient instability mechanism and enhanced control for Grid-Forming controlled voltage source converter (GFM-VSC) during sags has been widely investigated. However, the postfault performance are overlooked in previous studies. In this paper, windup problem of GFM-VSC with virtual inertia is first revealed based on established piecewise nonlinear model power angle curve. Second, impact key parameters stability phenomenon analyzed, revealing that conventional deceleration effect...

Circulating tumor cells (CTCs) have become known as minimally invasive multifunctional biomarkers for earlier diagnosis, prognosis, recurrence risk assessment, and therapeutic monitoring in recent years. However, effectively capturing these CTCs is still difficult because of the extremely low abundance diverse phenotypes cancer cells. In this study, we present a novel necklace-like polydopamine nanosphere (PDA NS)/alginate composite nanofiber with hierarchical nanotopographical structure...

The effective detection and release of circulating tumor cells (CTCs) are great significance for cancer diagnosis monitoring. microfluidic technique has proved to be a promising method CTCs isolation subsequent analysis. However, complex micro-geometries or nanostructures were often constructed functionalized improve the capture efficiency, which limited scale-up high-throughput production larger-scale clinical applications. Thus, we designed simple conductive nanofiber chip...

We present the design process of a highly portable integrated power system simulator developed to support investigation into human interface for complex hydro system. The most important development phases are described followed by insights that guided developers final version. architecture is explained in detail. submodels clarify concepts and used as well minimal hardware requirements needed run simulator. Finally we some results captured during experimental sessions performed with...

Transient stability issues of power converter systems have attracted much attention. Generally, the are high-order nonlinear due to multiple cascaded control loops, which become obstacles for transient analysis. However, many conventional methods, including well-known Equal Area Criterion, only applicable second-order without considering damping effects. To fill this gap, an iterative Criterion is proposed handle higher-order systems. Considering dynamic coupling between active and reactive...

Complicated dynamic interactions in multi-grid-connected converter (GCC) systems have unexpected impacts on the overall response of system. Online state sharing between different GCCs can enhance coordination whole However, due to significant communication delay, power angle and frequency states cannot be transmitted rapidly enough. In this letter, an innovative remote estimation method is proposed realize real-time information with local measurement voltage power. This decouples interactive...