Topotecan, a topoisomerase I inhibitor, is an anticancer drug widely used in the therapy of lung, ovarian, colorectal, and breast adenocarcinoma. Due to primary dose-limiting toxicity topotecan, which myelosuppressive, it necessary identify other chemotherapeutic agents that can work synergistically with topotecan increase its efficacy limit toxicity. Many studies have shown synergism upon combination such as gemcitabine. Other demonstrated pre-exposing cells naturally occurring compounds...

Flaxseeds have been known for their anti-cancerous effects due to the high abundance of lignans released upon ingestion. The most abundant lignan, secoisolariciresinol diglucoside (SDG), is ingested during dietary intake flax, and then metabolized in gut into two mammalian lignan derivatives, Enterodiol (END) Enterolactone (ENL). These were previously reported possess anti-tumor against breast, colon, lung cancer. This study aims investigate potential effect flaxseed SDG, END ENL on acute...

Beta thalassemia is an inherited disorder resulting in abnormal or decreased production of hemoglobin, leading to hemolysis and chronic anemia. The long-term complications can affect multiple organ systems, namely the liver, heart, endocrine. Myocardial iron overload a common finding β-thalassemia. As result, different cardiovascular form cardiomyopathy, pulmonary hypertension, arrhythmias, vasculopathies occur, extreme cases, sudden cardiac death. Each these pertains underlying etiologies...

Annona cherimola Mill is a large green fruit with black seeds widely known to possess toxic properties due the presence of Annonaceous acetogenins. The present study investigates anti-cancer an ethanolic seed extract on Acute Myeloid Leukemia (AML) cell lines in vitro and elucidates underlying cellular mechanism. anti-proliferative effects various AML normal mesenchymal cells (MSCs) were assessed using WST-1 viability reagent. pro-apoptotic effect was evaluated Annexin V/PI staining Cell...

Studies on tocotrienols have progressively revealed the benefits of these vitamin E isoforms human health. Beta-tocotrienol (beta-T3) is known to be less available in nature compared other members, which may explain restricted number studies beta-T3. In present study, we aim investigate anti-proliferative effects and pro-apoptotic mechanisms beta-T3 two breast adenocarcinoma cell lines MDA-MB-231 MCF7. To assess viability, both were incubated for 24 48 h, with different concentrations...

Topotecan (TP) is an anticancer drug acting as topoisomerase I inhibitor that used in the treatment of many types cancers including leukemia, but it has significant side effects. Andrographolide, a compound extracted from Andrographis paniculata, was recently proven to inhibit growth cancer cells and can induce apoptosis. The aim this study investigate possible synergism between TP andrographolide acute myeloid vitro.U937 leukemic were cultured using Roswell Park Memorial Institute (RPMI)...

Abstract Background The edible fruit Annona cherimola has previously shown many nutritional and medicinal properties. current study evaluates the anti-cancer anti-proliferative properties of ethanolic leaf extract (AELE) on Acute Myeloid Leukemia (AML) cell lines cultured in vitro (Monomac-1 KG-1). Methods effect A. was evaluated via viability assay. Its pro-apoptotic assessed through Cell Death ELISA dual Annexin V/PI staining. To further investigate molecular mechanism by which promoted...

Malva pseudolavatera Webb & Berthel. is a plant from the Malvaceae family that has long been included in human diet due to its various curative effects. Many leaf extracts species of genus have reported possess anti-cancer properties, however, studies on M. leaves documented anti-inflammatory and anti-oxidant effects with no emphasis their possible potential. The present study explores properties extract acute myeloid leukemia (AML) cell lines vitro deciphers underlying molecular mechanism....

Splenic infarction has been reported as a rare complication of infectious mononucleosis (IM), documented in only few case reports. We present the patient diagnosed with IM complicated by splenic infarction, thrombophilia workup revealing homozygous methylenetetrahydrofolate reductase (MTHFR) mutation and elevated homocysteine levels. Infections play critical role thrombosis formation through various mechanisms, primarily inflammation due to cytokine production, which alters coagulation...

Urtica dioica (UD), commonly known as “stinging nettle”, is a herbaceous flowering plant that widely used agent in traditional medicine worldwide. Several formulations of UD leaf extract have been reported to exhibit anti-inflammatory and antioxidant properties, with anticancer potential. The current study investigated the possible properties nettle tea, prepared from leaves, on acute myeloid leukemia (AML) cell lines, deciphered underlying molecular mechanisms. Treatment AML lines (U-937...

Acute myeloid leukemia (AML) is a blood cancer characterized by the formation of faulty defective myelogenous cells with morphological heterogeneity and cytogenic aberrations leading to loss their function. In an attempt find effective safe AML treatment, vitamin E derivatives, including tocopherols were considered as potential anti-tumor compounds. Recently, other isoforms E, namely tocotrienols have been proposed potent anti-cancerous agents, displaying promising therapeutic effects in...

Colorectal Cancer (CRC) is a common cause of oncological deaths worldwide. Alterations the epigenetic landscape constitute well-documented hallmark CRC phenotype. The accumulation aberrant DNA methylation and histone acetylation plays major role in altering gene activity driving tumor onset, progression metastasis.In this study, we evaluated effect Suberoylanilide Hydroxamic Acid (SAHA), panhistone deacetylase inhibitor, Decitabine (DAC), methyltransferase either alone or combination, on...

Annonaceae family has broad uses in herbal medicine for treatment of several diseases, whether through seeds' or leaves' extracts. The present study investigates the antiproliferative and antitumor activity Annona cherimola aqueous leaf (AAL) extract/infusion acute myeloid leukemia (AML) cell lines vitro. High-resolution LC-MS was first used to analyze composition extract. Cell proliferation assay, Annexin V staining, cycle analysis, dual V/PI death quantification by ELISA, ROS level...

Atypical epigenetic processes including histone acetylation and DNA methylation have been identified as a fundamental theme in hematologic malignancies. Such mechanisms modify gene expression prompt, part at least, the initiation progression of several malignancies acute myeloid leukemia. In current study we determined effects treating KG-1 U937 leukemia (AML) cells, vitro, with HDAC inhibitor, suberoylanilide hydroxamic acid (SAHA), or DNMT decitabine (DAC), their combination, on cell...

Breast Cancer is one of the most commonly diagnosed cancers worldwide and a major cause death among women. Although chemotherapeutic agents remain keystones in cancer therapy, significant side effects have failed to provide safe tolerable treatment for patients. Dietary antioxidant vitamins were extensively investigated over past years their relevance chemotherapy remains be elucidated.In current study, we aimed investigate anti-proliferative apoptotic combining γ-tocotrienol, member vitamin...