A5033513219- Adipose Tissue and Metabolism
- Chemokine receptors and signaling
- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Hematopoietic Stem Cell Transplantation
- Viral Infections and Immunology Research
- Immune Cell Function and Interaction
- Cardiovascular Disease and Adiposity
- Fatty Acid Research and Health
- Atherosclerosis and Cardiovascular Diseases
- Neutropenia and Cancer Infections
- CRISPR and Genetic Engineering
- Genomics and Rare Diseases
Beike Biotechnology (China)
2025
Centre for Human Drug Research
2016-2021
Leiden University
2016-2021
Cancer Institute (WIA)
2000
Abstract Objectives β-thalassemias, caused by mutations in HBB , are hereditary blood disorders that impose a significant global health burden. Detecting these through accurate genetic analysis is essential. This study aimed to create panel of cell type reference materials for β-thalassemia testing using prime editing (PE), flexible and precise genomic method. Methods PE3 systems were designed target specific mutations, including single nucleotide variants (SNVs) (−32 (C>A), CD 17...
Background and aimsArginase1 (Arg1), an M2 macrophage marker, plays a critical role in number of immunological functions macrophages, which are the main cell type facilitating atherosclerotic lesion development. Arg1 uses substrate l-arginine to create l-ornithine, precursor molecule required for collagen formation vascular smooth muscle differentiation. By reducing availability, limits production nitric oxide (NO), pro-atherogenic factor macrophages. In endothelial cells, conversely, NO is...
Abstract Total body upstream stimulatory factor 1 (USF1) deficiency in mice is associated with brown adipose tissue activation and a marked protection against the development of obesity atherosclerotic lesions. Functional expression USF1 has also been detected monocytes monocyte-derived macrophages. In current study we therefore tested whether selective hematopoietic can beneficially impact atherosclerosis. For this purpose, LDL receptor knockout were transplanted bone marrow from or their...