A5046218226- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Hernia repair and management
- Pelvic and Acetabular Injuries
- Edible Oils Quality and Analysis
- Neuroscience and Neural Engineering
- Plant Stress Responses and Tolerance
- Lipid metabolism and biosynthesis
- Plant Molecular Biology Research
- Coconut Research and Applications
- Cardiomyopathy and Myosin Studies
- Abdominal Surgery and Complications
- Advanced Chemical Sensor Technologies
- Connexins and lens biology
- Marine Bivalve and Aquaculture Studies
- Atrial Fibrillation Management and Outcomes
- Pelvic floor disorders treatments
- Heat shock proteins research
- Sesame and Sesamin Research
- Fatty Acid Research and Health
- Isotope Analysis in Ecology
- Genomics, phytochemicals, and oxidative stress
- Marine and fisheries research
Taizhou People's Hospital
2023-2024
Northern Jiangsu People's Hospital
2023-2024
Nantong University
2023-2024
Shanghai Customs College
2019-2023
Guizhou University
2023
University of Manchester
2011-2020
Hydroxytyrosol (HT) and oleuropein (OL), the most abundant of phenolic compounds in olives, have anticancer properties against breast cancer (BC). However, little attention has been paid to mechanism HT or OL BC cells. The objective this study was identify underlying molecular mechanisms these compounds. ER-positive MCF7 T47D cells were treated with combination hepatocyte growth factor (HGF), rapamycin (Rapa, an agonist autophagy) 3-methyladenine (3-MA, inhibitor autophagy). Cell viability,...
Breast Cancer (BC) is the leading cause of cancer-related deaths among women. As such, novel chemotherapeutic agents are urgently needed, especially for Triple-Negative (TNBC). Hydroxytyrosol (HT) and Oleuropein (OL) rich in olive oil, which associated with a low occurrence BC. However, effects mechanisms action HT OL BC cells still unclear. This study aimed to explore molecular underlying antitumor effect TNBC.TNBC MDA-MB-231 were treated combination Hepatocyte Growth Factor (HGF),...
Postoperative seroma is the most common minor complication after inguinal hernia repair surgery and can have negative consequences. The objective of this study was to identify potential risk factors for postoperative seroma.This consecutively included 354 elderly patients with who underwent laparoscopic Transabdominal preperitoneal Patch Plasty (TAPP). Seroma diagnosis conducted by same experienced surgeon based on physical examinations combined ultrasound. Risk were identified through...
IntroductionConnexin 43 (Cx43) 3The abbreviations used are: Cx43connexin 43MKK4mitogen-activated protein kinase 4NRCMneonatal rat cardiomyocytePEphenylephrineAP-1activator protein-1ZO-1zonula occludens-1PESprogrammed electrical stimulationLucluciferaseTACtransverse aortic constrictionECGelectrocardiographyCVconduction velocitySP-1specific protein-1QTccorrected QTrCx43rat Cx43AdadenoviruscaMKK4constitutively active MKK4dnMKK4dominant negative MKK4. is the predominant isoform of gap junction...
Biophysically detailed mathematical models of cardiac electrophysiology provide an alternative to experimental approaches for investigating possible ionic mechanisms underlying the genesis electrical action potentials and their propagation through heart. The aim this study was develop a biophysically model mouse atrial myocytes, popular elucidating molecular cellular arrhythmogenesis. Based on data from isolated murine cells set equations describing biophysical properties membrane ion...
This simulation study aims to investigate how the Calcium/calmodulin-dependent protein kinase II (CaMKII) overexpression and oxidation would influence cardiac electrophysiological behavior its arrhythmogenic mechanism in atria. A new-built CaMKII module a refitted were integrated into mouse atrial cell model for analyzing variations action potential (AP) characteristics intracellular Ca 2+ cycling under different conditions. Simulation results showed that significantly increased...
Cardiac alternans is a dynamical phenomenon in cardiomyocytes, which linked to the genesis of cardiac mechanical dysfunction and lethal arrhythmias. The beat-to-beat alteration may occur amplitude Ca <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2+</sup> transients (CaT) or action potential duration (APD). Typically, APD secondary consequence CaT generation relevant imbalance sarcoplasmic reticulum (SR) release uptake. However, effect...
A comprehensive analytical method based on gas chromatography-mass spectrometry (GC-MS) was developed for the determination of 3-monochloropropanediol esters, 2-monochloropropanediol and glycidyl esters in vegetable oils. Different parameters, such as bromination reaction temperature, time, derivatization reagent dosage, derivative were studied. The optimal conditions follows: 0.25 g oil weighed a 10-mL glass tube, followed by addition 2 mL tetrahydrofuran, 25 μL internal working standard...