A5043552100- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
- Photosynthetic Processes and Mechanisms
- Photochemistry and Electron Transfer Studies
- Nanoplatforms for cancer theranostics
- Electrochemical Analysis and Applications
- Lanthanide and Transition Metal Complexes
- Photoreceptor and optogenetics research
- bioluminescence and chemiluminescence research
- Analytical Chemistry and Chromatography
- Dye analysis and toxicity
- Electron Spin Resonance Studies
- Molecular Junctions and Nanostructures
- Electrocatalysts for Energy Conversion
- Molecular Sensors and Ion Detection
- Lipid Membrane Structure and Behavior
- Polymer Surface Interaction Studies
- Luminescence and Fluorescent Materials
- Bone Tissue Engineering Materials
- Spectroscopy and Quantum Chemical Studies
- Electrochemical sensors and biosensors
- Metabolism and Genetic Disorders
- DNA and Nucleic Acid Chemistry
- Antibiotic Resistance in Bacteria
- Folate and B Vitamins Research
Consejo Nacional de Investigaciones Científicas y Técnicas
2018-2023
Universidad Nacional de La Plata
2018-2023
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
2018-2023
Arizona State University
2019-2022
Universidad Nacional de Córdoba
2010-2019
Centro Universitario Allende
2016
Arthroplasty is a highly successful treatment to restore the function of joint. The contamination implant via bacterial adhesion first step toward development device-associated infections. emerging concern about antimicrobial resistance resulted in growing interest develop alternative therapeutic strategies. Thus, increment incidence periprosthetic infections, complexity treating infections caused by organisms biofilms, together with rise antibiotic resistant bacteria, expose need design...
The essential role of a well-defined hydrogen-bond network in achieving chemically reversible multiproton translocations triggered by one-electron electrochemical oxidation/reduction is investigated using pyridylbenzimidazole–phenol models. two molecular architectures designed for these studies differ with respect to the position N atom on pyridyl ring. In one structures, extends uninterrupted across molecule from phenol group. Experimental and theoretical evidence indicates that an overall...
Pterins are natural products that can photosensitize the oxidation of DNA, proteins, and phospholipids. Recently, a new series decyl-chain (i.e., lipophilic) pterins were synthesized their photophysical properties investigated. These decyl-pterins led to efficient intercalation in large unilamellar vesicles produced, under UVA irradiation, singlet molecular oxygen, highly oxidative species react with polyunsaturated fatty acids (PUFAs) form hydroperoxides. Here, we demonstrate association...
Expanding proton-coupled electron transfer to multiproton translocations (MPCET) provides a bioinspired mechanism transport protons away from the redox site. This expansion has been accomplished by separating initial phenolic proton donor pyridine-based terminal acceptor Grotthuss-type wire made up of concatenated benzimidazoles that form hydrogen-bonded network. However, it was found midpoint potential phenol oxidation launched is function number in network; becomes less positive (i.e.,...
In order to develop a new long alkane chain pterin that leaves the core largely unperturbed, we synthesized and photochemically characterized decyl pterin-6-carboxyl ester (CapC) preserves amide group. CapC contains decyl-chain at carboxylic acid position condensed DMF molecule N2 position. Occupation of on pendent group retains acid-base equilibrium headgroup due its somewhat remote location. This compound has relatively high fluorescence emission singlet oxygen quantum yields attributed...
New Fuchsin (NF), also known as Magenta III, has potential applications in photodynamic therapy.The commercial product labeled NF contains two other dye components different proportions, II and I (Rosaniline).The proportions of NF, II, determined by reversed-phase high-performance liquid chromatography (RP-HPLC) the sample used were 71.6 ± 0.4%, 25.2 0.2%, 2.8 0.1% (n = 7), respectively.The isolation, purification, characterization carried out applying techniques, such preparative column...
Novel compounds exhibited good properties in comparison with the corresponding starting reagent and satisfy conditions of a potential drug.
Photoinduced proton-coupled electron transfer and long-range two-proton transport via a Grotthuss-type mechanism are investigated in biomimetic construct. The ultrafast, nonequilibrium dynamics assessed two-dimensional electronic vibrational spectroscopy, concert with electrochemical computational techniques. A low-frequency mode is identified experimentally found to promote double proton transfer, supported by recent theoretical simulations of similar but abbreviated (non-photoactive)...
Alkylation patterns and excited-state properties of pterins were examined both experimentally theoretically. 2D NMR spectroscopy was used to characterize the pterin derivatives, revealing undoubtedly that decyl chains coupled either O4 or N3 sites on pterin. At a temperature 70°C, alkylation regioselectively favored over N3. The also when using solvents, in which reactants had increased solubility, namely N,N-dimethylformamide N,N-dimethylacetamide, rather than solvents very low solubility...
Cresyl violet and cresyl red, components of commercial acetate, were separated purified using preparative column liquid chromatography. The stationary phase was silica gel gradient elution carried out chloroform:methanol. dyes obtained in high yield; 51% the original lot recovered as 40% red. Separated materials characterized by nuclear magnetic resonance mass spectroscopy; UV-visible Fourier-transform infrared spectra also for samples pure colored constituents dye identified thin layer...
Mono- and bis-decylated lumazines have been synthesized characterized. Namely, mono-decyl chain [1-decylpteridine-2,4(1,3H)-dione] 6a bis-decyl [1,3-didecylpteridine-2,4(1,3H)-dione] 7a conjugates were by nucleophilic substitution (SN 2) reactions of lumazine with 1-iododecane in N,N-dimethylformamide (DMF) solvent. Decyl coupling occurred at the N1 site then N3 a sequential manner, without DMF condensation. Molecular orbital (MO) calculations show p-orbital but not , which along...
In water-oxidizing photosynthetic organisms, excitation of the reaction-center chlorophylls (P680) triggers a cascade electron and proton transfer reactions that establish charge separation across membrane proton-motive force. An early oxidation step in this process involves proton-coupled (PCET) via tyrosine-histidine redox relay (Yz-H190). Herein, we report synthesis structural characterization two isomeric dyads designed to model PCET process. Both are based on same high potential...
Abstract The photodynamic activity of Neutral Red and the new monobrominated was studied in suspensions Staphylococcus aureus . effect mannitol sodium azide presence 25 μ m photosensitizer on lethal photosensitization were investigated. results mechanistic evaluation showed that both produced a completed protective after irradiation without significant differences between them. also microorganisms with addition mannitol. Although photoinactivation, it incomplete less than exhibited by...