A5102901736- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Pulmonary Hypertension Research and Treatments
- Cardiac Fibrosis and Remodeling
- RNA Research and Splicing
- Neuroinflammation and Neurodegeneration Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Bioinformatics and Genomic Networks
- Machine Learning in Bioinformatics
- Nuclear Receptors and Signaling
- Microbial Metabolic Engineering and Bioproduction
- Auction Theory and Applications
- Power System Optimization and Stability
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiomyopathy and Myosin Studies
- Estrogen and related hormone effects
- Cardiovascular Disease and Adiposity
- Chromosomal and Genetic Variations
- Optimal Power Flow Distribution
- Advanced Proteomics Techniques and Applications
- Genomics and Phylogenetic Studies
- Cardiovascular Issues in Pregnancy
- Evolutionary Algorithms and Applications
Amity University
2022
Stockholm School of Economics
2020
University of California, Los Angeles
2014-2018
Indiana University Bloomington
2017-2018
Amity University
2017
UCLA Health
2012-2015
Sharma & Associates (United States)
2011-2013
University of Miami
2010-2013
Institute of Bioinformatics
2005-2006
Sexual dimorphism is observed in most human diseases. The difference the physiology and genetics between sexes can contribute tremendously to disease prevalence, severity, outcome. Both hormonal genetic differences males females lead gene expression patterns that influence risk course. MicroRNAs have emerged as potential regulatory molecules all organisms. They a broad effect on every aspect of physiology, including embryogenesis, metabolism, growth development. Numerous microRNAs been...
Plasma is one of the best studied compartments in human body and serves as an ideal fluid for diagnosis diseases. This report provides a detailed functional annotation all plasma proteins identified to date. In all, gene products encoded by 3778 distinct genes were annotated based on previously published literature identification multiple peptides from under HUPO's Proteome Project. Our analysis revealed that 51% these more than protein isoform. All single nucleotide polymorphisms involving...
Background— Pulmonary arterial hypertension is a chronic lung disease associated with severe pulmonary vascular changes. A pathogenic role of oxidized lipids such as hydroxyeicosatetraenoic and hydroxyoctadecadienoic acids well established in disease. Apolipoprotein A-I mimetic peptides, including 4F, have been reported to reduce levels these improve However, the progression therapeutic action 4F are not established. Methods Results— We studied 2 different rodent models (PH): monocrotaline...
Myocardial fibrosis and calcification associate with adverse outcomes in nonischemic heart failure. Cardiac fibroblasts (CF) transition into myofibroblasts (MF) osteogenic (OF) to promote myocardial calcification. However, common upstream mechanisms regulating both CF-to-MF CF-to-OF remain unknown. microRNAs are promising targets modulate CF plasticity. Our bioinformatics revealed downregulation of miR-129-5p upregulation its small leucine-rich proteoglycan Asporin (ASPN) transcription...
Significant advancements have been made in unraveling and understanding the non-coding elements of human genome. New insights into structure function noncoding RNAs emerged. Their relevance context both physiological cellular homeostasis diseases is getting appreciated. As a result, exploration RNAs, particular microRNAs (miRs), as therapeutic agents or targets strategies under way. This review summarizes discusses depth current literature on role miRs neurodegenerative diseases.
Recently, we showed that exogenous treatment with estrogen (E2) rescues pre-existing advanced heart failure (HF) in mice. Since most of the biological actions E2 are mediated through classical receptors alpha (ERα) and/or beta (ERβ), and both these present heart, examined role ERα ERβ rescue action against HF.Severe HF was induced male mice by transverse aortic constriction-induced pressure overload. Once ejection fraction (EF) reached ~ 35%, were treated selective agonists for (PPT, 850...
Pulmonary hypertension (PH) is a progressive lung disease associated with proliferation of smooth muscle cells and constriction microvasculature, leading to increased pulmonary arterial pressure, right ventricular failure, death. We have previously shown that genistein rescues preexisting established PH by significantly improving heart function. (Matori H, Umar S, Nadadur RD, Sharma Partow-Navid R, Afkhami M, Amjedi Eghbali M. Hypertension 60: 425-430, 2012). Here, we examined the role...
The events of damaging blackouts, voltage fluctuation and collapses are a point major concern for electricity boards, power system engineers the consumers all over globe. Better compensation reactive in will lead to better profile, improving overall quality. In this paper authors focusing on IEEE-9 Bus using thyristor controlled series capacitor. simulation analysis data is carried out Mipower (version9.0) software. Netwon Raphson method load flow solutions has been used. At first we have...
Objective To characterize downstream effectors of p300 acetyltransferase in the myocardium. Background Acetyltransferase is a central driver hypertrophic response to increased workload, but its biological targets and are incompletely known. Methods Results Mice expressing myocyte-restricted transgene encoding p300, previously shown develop spontaneous hypertrophy, were observed undergo robust compensatory blood vessel growth together with angiogenic gene expression. Chromatin...
MicroRNAs (miRs) are 18~23 nucleotides long non-coding RNAs that regulate gene expression. To explore whether miR alterations in tauopathy contribute to pathological conditions, we first determined which hippocampal miRs altered at the presymptomatic and symptomatic stages of using rTg4510 mice (Tau mice), a well-characterized model. miR-RNA pairing analysis QIAGEN Ingenuity Pathway Analysis (IPA) revealed 401 genes can be regulated by 71 Tau hippocampi stage. Among several confirmed with...
With renewable energy having the potential to be chief source of for coming generations, wind will have a vital role play. Obtaining good quality electricity from turbine systems under varying conditions is crucial. An effective control design essential obtain desired results. This study focused on achieving rotor speed and frequency doubly fed induction generator (DFIG) turbines using different controllers. Three techniques namely genetic algorithm (GA), Simulink response/design...
Background: p300 is a dose-dependent and limiting regulator of cardiac hypertrophy. regulates hypertrophy by controlling the expression specific microRNAs. Objective: To dissect role miR142 during hypertrophic growth to verify its targets. Methods Results: In mice with myocardial overexpression (OE) (p300tg) in acute ischemia, we observed altered microRNAs miR142-5p -3p (miR142). Induction myocyte vitro vivo were associated downregulation miR142. serum was sensitive inhibitors ERK/MAPK JNK...
MicroRNAs (miRs) are small non-coding RNA molecules that regulate gene expression. Circulating miRs in the plasma very stable and being explored as early-onset biomarkers to detect AD. Indeed, several studies have shown miR changes AD patients (J Alzheimers Dis.2008May;14(1):27–41) rTg4510 mouse line overexpressing human P301L Tau only forebrain is a great animal model examine resulting from overexpression. Deep Sequencing using Illumina platform (LC Sciences) was performed on hippocampus...
Introduction: Bupivacaine overdose leads to lethal arrhythmias and cardiac arrest. Lipid emulsion (LE) is cardioprotective rescues toxicity. Although both lipid sink metabolic theories have been proposed, yet the exact molecular mechanism not known. G protein-coupled receptor 40 (GPR40), also known as free fatty acid receptor-1 activated by medium long chain acids. Among receptors, GPR40 expression one of highest in heart. Hypothesis: As acids, we hypothesized that may mediate LE’s rescue...
Pulmonary hypertension (PH) is a chronic lung disease associated with severe vascular disorders leading to right ventricular(RV) failure. An HDL mimetic peptide, 4F, has been shown be effective for the treatment of atherosclerosis and number inflammatory disorders. Here, we explored whether 4F can rescue advanced PH by controlling expression specific microRNAs (miRs). was induced in rats single injection monocrotaline (MCT, 60mg/kg, s.c .) or placing mice hypoxia chamber(O2≤10%) 21 days....
Pulmonary hypertension (PH) is a chronic lung disease characterized by progressively elevated pulmonary arterial pressures and severe vascular remodeling resulting from interactions between oxidized lipoprotein deposition increased endothelial proliferation. Previously we have shown plasma levels of biological oxidation products such as hydroxyoctadecadienoic acids (HODEs) hydroxyeicosatetraenoic (HETEs) in the rat monocrotaline model PH. Here investigated role HETEs HODEs development PH...
Background: Pulmonary hypertension (PH) causes increase in pulmonary arterial pressure causing right ventricular (RV) hypertrophy and RV failure (RVF). We have shown that apolipoprotein A-I mimetic peptide 4F rescues advanced PH decreases circulating levels of oxidized fatty acids [hydroxyoctadecadienoic (HODEs) hydroxyeicosatetraenoic acids(HETEs)] the MCT rat-model PH. Here, we show rats mice by inducing miR-193-3p (miR193), which regulates enzymes responsible for production HETEs HODEs....
Abstract Histone deacetylase (HDAC) inhibitors have been extensively studied as potential anticancer treatments and several are currently in clinical trials. p300 is a nuclear histone acetyltransferase that an important coordinator of multiple transcription-dependent cellular processes. HDAC may directly indirectly increase the activity p300. The role dependent on cell context but most or all its biological stems from ability to acetylate histones non-histone nucleoproteins including p53,...