A5027341861- Fluorine in Organic Chemistry
- Crystallization and Solubility Studies
- Analytical Chemistry and Chromatography
- Inorganic Fluorides and Related Compounds
- X-ray Diffraction in Crystallography
- Atmospheric chemistry and aerosols
- Spectroscopy and Laser Applications
- Insect Pheromone Research and Control
- Synthesis and Reactions of Organic Compounds
- Advanced Chemical Physics Studies
York University
2022-2023
Reed College
2019-2020
A BF3-catalyzed atom-economical fluorocarbamoylation reaction of alkyne-tethered carbamoyl fluorides is reported. The catalyst acts as both a fluoride source and Lewis acid activator, thereby enabling the formal insertion alkynes into strong C-F bonds through halide recycling mechanism. developed method provides access to 3-(fluoromethylene) oxindoles γ-lactams with excellent stereoselectivity, including fluorinated derivatives known protein kinase inhibitors. Experimental computational...
Abstract Due to the unique properties of C−F bonds, organofluorine compounds occupy a privileged space in pharmaceutical, agrochemical, and polymer industries. Carbofluorination reactions involve formation C−C bond, typically across π‐bond or another unsaturated functionality that is revealed upon situ activation. The design tailored substrates new catalyst systems has enabled carbofluorination chemistry emerge as promising manifold for synthesis fluorinated scaffolds. This review covers...
Abstract. Organic nitrate esters are key products of terpene oxidation in the atmosphere. We report here preparation and purification nine derived from (+)-3-carene, limonene, α-pinene, β-pinene perillic alcohol. The availability these compounds will enable detailed investigations into structure–reactivity relationships aerosol formation processing allow individual aqueous-phase reactions organic esters.
Abstract. Organic nitrate esters are key products of terpene oxidation in the atmosphere. We report here preparation and purification nine derived from (+)-(3)-carene, limonene, α-pinene, β-pinene perillic alcohol. The availability these compounds will enable detailed investigations into structure reactivity relationships aerosol formation processing allow individual aqueous phase reactions organic esters.
A BF3-catalyzed atom-economical fluorocarbamoylation reaction of alkyne-tethered carbamoyl fluorides is reported. The catalyst acts as both a fluoride source and Lewis acid activator, enabling the formal insertion alkynes into strong C–F bonds. Our proposed mechanism involves addition to alkyne via nucleophilic fluoroborate species, followed by cyclization onto moiety with concomitant release fluoride. developed method provides access 3-fluoromethylene oxindoles γ-lactams excellent...
A BF3-catalyzed atom-economical fluorocarbamoylation reaction of alkyne-tethered carbamoyl fluorides is reported. The catalyst acts as both a fluoride source and Lewis acid activator, enabling the formal insertion alkynes into strong C–F bonds through halide recycling mechanism. developed method provides access to 3-(fluoromethylene)oxindoles γ-lactams with excellent stereoselectivity, including fluorinated derivatives known protein kinase inhibitors. Experimental computational studies...
0.5 0.0 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0 5.5 6.0 6.5 7.0 7.5 8.0 8.5 9.0 9.5 10.0 f1 (ppm) rkl02-08A.9.fid