A5082960018- Neuroscience of respiration and sleep
- Neuroendocrine regulation and behavior
- Heart Rate Variability and Autonomic Control
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
- Renin-Angiotensin System Studies
- Neuroscience and Neuropharmacology Research
- Sleep and related disorders
- Eicosanoids and Hypertension Pharmacology
- High Altitude and Hypoxia
- Nitric Oxide and Endothelin Effects
- Neonatal and fetal brain pathology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Vestibular and auditory disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Neurotoxicity Research
- Adipose Tissue and Metabolism
- Spaceflight effects on biology
- Food Allergy and Anaphylaxis Research
- Neurological Disorders and Treatments
- Optical Imaging and Spectroscopy Techniques
- Dietary Effects on Health
- Neuropeptides and Animal Physiology
Toyo University
2011-2024
The University of Sydney
2004-2014
Robert Bosch (Australia)
2007-2011
National Defense Medical College
2001-2003
University of Yamanashi
1994-2000
The dorsomedial hypothalamic nucleus (DMH) is believed to play a key role in mediating vasomotor and cardiac responses evoked by an acute stress. Inhibition of neurons the rostral ventrolateral medulla (RVLM) greatly reduces increase renal sympathetic nerve activity (RSNA) activation DMH, indicating that RVLM mediate, at least part, component DMH-evoked response. In this study, first aim was determine whether medullary raphe pallidus (RP) region also contribute response, because it has been...
Activation of neurons in the dorsomedial hypothalamus (DMH) evokes increases mean arterial pressure (MAP), sympathetic activity, heart rate (HR) and respiratory activity. Results previous studies suggest that DMH‐evoked MAP HR are mediated by within periaqueductal grey (PAG), but a recent study has proposed converse is also true, i.e. evoked from PAG depend upon neuronal activity DMH. In this anaesthetized rats, we examined functional relationship between DMH regulating renal nerve (RSNA)...
Abstract Psychological stress evokes increases in sympathetic activity and blood pressure, which are due at least part to an upward resetting of the baroreceptor‐sympathetic reflex. In this study we determined whether premotor neurons rostral ventrolateral medulla ( RVLM ), have a critical role reflex control activity, activated during air puff stress, moderate psychological stressor. Secondly, identified that by also project nucleus tractus solitarius NTS key site for modulation...
Neurons within the dorsomedial hypothalamic nucleus (DMH) and perifornical area (PeF), which lie classic defense area, subserve cardiovascular response to psychological stress. Previous studies have shown that electrical stimulation of causes inhibition cardiac (in some cases) sympathetic components baroreceptor reflex. In contrast, naturally evoked stress does not appear be associated with such inhibition. this study, we tested effect specific activation neurons DMH PeF on baroreflex...
Circulating ANG II modulates the baroreceptor reflex control of heart rate (HR), at least partly via activation type 1 (AT ) receptors on neurons in area postrema. In this study, we tested hypothesis that effects circulating baroreflex also depend AT within nucleus tractus solitarius (NTS). confirmation previous studies other species, increases arterial pressure induced by intravenous infusion had little effect HR urethane-anesthetized rats, contrast to marked bradycardia evoked equipressor...
Neurons within the dorsomedial hypothalamus (DMH) play a critical role in subserving cardiovascular and neuroendocrine response to psychological stress. An increase respiratory activity is also characteristic feature of physiological stress, but there have been few studies DMH neurons regulating activity. In this study we determined effects activation on (assessed by measuring phrenic nerve activity, PNA) relationship between evoked changes sympathetic vasomotor spontaneously breathing...
Orexin neurons form a restricted group in the dorsal hypothalamus. The is centered on perifornical area within classic hypothalamic defense area, an which when activated produces marked cardiovascular and respiratory effects. Central administration of orexin can produce cardiorespiratory effects, but extent to contributes such responses evoked from hypothalamus not clear. To determine this, we used dual receptor antagonist Almorexant challenge effects by disinhibition Bicuculline (10 20...
The midbrain periaqueductal gray (PAG) mediates the physiological responses to a wide range of stressors. It consists four longitudinal columns that have different anatomical connections and functional properties. Previous behavioral studies led hypothesis dorsolateral PAG, but not adjacent lateral dorsomedial subregions, is key center integrates response acute psychological threatening stimuli. In this study, we tested whether, consistent with hypothesis, activation neurons in PAG evokes...
The superior and inferior colliculi are believed to generate immediate highly coordinated defensive behavioral responses threatening visual auditory stimuli. Activation of neurons in the have been shown evoke increases cardiovascular respiratory activity, which may be components more generalized stereotyped responses. In this study, we examined possibility that there "command neurons" within can simultaneously drive sympathetic outputs. anesthetized rats, microinjections bicuculline (a...
The peptidic ANG II receptor antagonists [Sar 1 ,Ile 8 ]ANG (sarile) or ,Thr (sarthran) are known to decrease arterial pressure and sympathetic activity when injected into the rostral part of ventrolateral medulla (VLM). In anesthetized rabbits rats, profound depressor sympathoinhibitory response after bilateral microinjections sarile sarthran VLM was unchanged prior selective blockade angiotensin type (AT ) ANG-(1—7) receptors, although this abolished effects exogenous II. Unlike...