A5006472424- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- RNA Research and Splicing
- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Genomics and Chromatin Dynamics
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Reactions
- Asymmetric Hydrogenation and Catalysis
- Marine Sponges and Natural Products
- Plant biochemistry and biosynthesis
- Nuclear Structure and Function
- Asymmetric Synthesis and Catalysis
- Chemical synthesis and alkaloids
University of Chicago
2018-2020
McGill University
2018
A dienamine mediated asymmetric Diels–Alder reaction between an array of α,β-unsaturated enals and electron-deficient pyrones is presented along with further transformations the obtained products models for observed stereoselectivity.
Concise syntheses of spiroviolene and spirograterpene A have been achieved from a common intermediate, indicating structure revision one is necessary along with implications for its biosynthesis.
Although electrophile-promoted polyene cyclizations have long been a mainstay transformation for the rapid and stereocontrolled preparation of varied natural products designed molecules, efforts to effect sulfur-promoted variants arguably lagged behind other counterparts. This state affairs is particularly true with alkyl sulfide-based electrophiles, even in racemic variants. Herein, building on previously reported discoveries, described distinct modular method prepare range isolable aryl...