A5103141962- Liver Disease Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Liver physiology and pathology
- Microbial Metabolites in Food Biotechnology
- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and biosynthesis
- Enzyme Production and Characterization
- Pancreatic function and diabetes
- Nanocomposite Films for Food Packaging
- Cerebrovascular and Carotid Artery Diseases
- Advanced Glycation End Products research
- Biofuel production and bioconversion
- Microbial bioremediation and biosurfactants
- Probiotics and Fermented Foods
- Curcumin's Biomedical Applications
- Enzyme Catalysis and Immobilization
- Microbial Community Ecology and Physiology
- Hepatitis C virus research
- Biochemical Analysis and Sensing Techniques
- Systemic Lupus Erythematosus Research
- Microbial Metabolic Engineering and Bioproduction
- COVID-19 Clinical Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Macrophage Migration Inhibitory Factor
- Polysaccharides and Plant Cell Walls
Washington University in St. Louis
2023-2025
Hubei University of Technology
2009-2024
Guangdong Provincial People's Hospital
2017-2024
Dalian Maritime University
2017-2022
Southern Medical University
2019-2021
Wuhan University of Technology
2020
Saint Louis University
2007-2018
Center of Hubei Cooperative Innovation for Emissions Trading System
2013
Emory University
2006
University of Kentucky
1995
We previously demonstrated that curcumin, a polyphenolic antioxidant purified from turmeric, up-regulated peroxisome proliferator-activated receptor (PPAR)-γ gene expression and stimulated its signaling, leading to the inhibition of activation hepatic stellate cells (HSC) in vitro. The current study evaluates vivo role curcumin protecting liver against injury fibrogenesis caused by carbon tetrachloride (CCl<sub>4</sub>) rats further explores underlying mechanisms. hypothesize might protect...
Diabetes is characterized by hyperglycaemia, which facilitates the formation of advanced glycation end-products (AGEs). Type 2 diabetes mellitus commonly accompanied non-alcoholic steatohepatitis, could lead to hepatic fibrosis. Receptor for AGEs (RAGE) mediates effects and associated with increased oxidative stress, cell growth inflammation. The phytochemical curcumin inhibits activation stellate cells (HSCs), major effectors during fibrogenesis. aim this study was explore underlying...
A new sensitive medium was developed to screen and isolate mutagenic Leuconostoc oenos strains defective in malolactic fermentation. The essential components of the included fructose (22 mM), l -malic acid (74.6 bromocresol green (as pH indicator), cellulose powder. wild-type colonies turned blue, but gave an reaction remained yellow-green.
An alkaline lipase strain of Pseudomonas aeruginosa HFE733 was isolated from soil samples domestic waste. The P. purified and characterized. enzyme 9.97-fold by means ammonium sulphate precipitation, Sephadex G-25 diethylaminoethyl (DEAE) cellulose chromatography. Purified protein analyzed sodium dodecyl polyacrylamide gel electrophoresis (SDS-PAGE), the molecular mass 51.0 kDa. exhibited maximum activity at 40 °C pH 8.5. is stable 7.0–8.5. It remarkably activated some metal ions chemical...
One cold-adapted strain, named Planococcus sp. XW-1, was isolated from the Yellow Sea. The strain can produce biosurfactant with petroleum as sole source of carbon at low temperature (4 °C). identified glycolipid-type species by thin-layer chromatography (TLC) and Fourier transform infrared spectroscopy (FTIR). It reduced surface tension water to 26.8 mN/m a critical micelle concentration measurement 60 mg/L. produced possesses high activity wide ranges (−18–105 °C), pH values (2–12), salt...
Abstract BACKGROUND Stevia has been proposed as a potential antidiabetic sweetener, mainly based on inconsistent results from stevioside or the plant extract, yet lacking relative experimental evidence individual steviol glycosides (SGs) and their metabolites. RESULTS The systematically revealed that typical SGs final metabolite (steviol) presented an effect streptozotocin (STZ) diabetic mice in all assayed aspects. In general, performance strength of samples followed sequence > glucosyl...
Minor ischemic stroke (MIS) patients face significant risks of recurrent strokes, necessitating reliable predictive tools. This single-center retrospective study developed and validated a novel model for predicting 1-year recurrence in MIS patients, defined as those with National Institutes Health Stroke Scale scores < 4 within seven days symptom onset. Among 218 (median age 64 years, 26.6% female), 32 (14.7%) experienced strokes one year. Analysis clinical lifestyle variables identified...
Abstract BACKGROUND Xylanase is the key enzyme involved in conversion of lignocelluloses. RESULTS An extracellular xylanase from Streptomyces althioticus LMZM submerged culture medium using corncob was purified and characterized. The 12.65‐fold through ammonium sulphate precipitation, Sephadex G‐25, DEAE cellulose chromatography, followed by gel filtration a G–100 column. molecular mass about 31.75 kDa . an endo‐xylanase, as it degraded xylan to xylooligosaccharide with non‐xylose after 24...
Hepatic stellate cell (HSC) activation occurs along with decreased Perilipin5 (Plin5) and liver fatty acid-binding protein (L-Fabp) expression coincident lipid droplet (LD) depletion. Conversely, the activated phenotype is reversible in WT HSCs upon forced of Plin5. Here, we asked if L-Fabp required for Plin5-mediated rescue quiescent phenotype. Lentiviral Plin5 transduction passaged L-Fabp−/− failed to reverse markers or restore lipogenic gene LD formation. However, adenoviral infection...
This paper proposes a framework for path tracking under additive disturbance when vehicle travels at high speed or on low-friction road. A decoupling control strategy is adopted, which made up of robust model predictive and the stability combining preview G-vectoring direct yaw moment control. vehicle-road adopted control, positively invariant set calculated online ensures state constraints in presence disturbances. Preview generates deceleration acceleration based lateral jerk, later...
Developing reusable and easy-to-operate biocatalysts is of significant interest in biodiesel production. Here, magnetic whole-cell catalysts constructed through immobilizing recombinant
Nerve growth factor (NGF) exists in the gut of adult rats. The cells responsible for NGF synthesis remain unknown. IEC-6 and Caco-2 cells, established cell culture models intestinal epithelial were studied to determine whether they synthesize release NGF. Conditioned media from both stimulated neurite outgrowth rat pheochromocytoma (PC-12) sensory neurons derived embryonic chick dorsal root ganglia (DRG). addition anti-NGF antibody blocked PC-12 partially DRG cells. An NGF-enzyme-linked...
Abstract A complex of chitosan (CS‐40) and nisin (CS‐40/nisin) was prepared characterized with Fourier transform infrared spectroscopy thermal analysis (thermogravimetry, differential thermogravimetry, scanning calorimetry). The results show that the formed mainly by electrostatic interaction between protonated amino group in CS‐40 backbone carboxylate ion nisin. Minimum inhibitory concentrations (MICs) were evaluated against Gram‐positive bacteria ( Staphylococcus aureus, Bacillus subtilis...