A5053534226- Bacillus and Francisella bacterial research
- Viral Infections and Outbreaks Research
- CRISPR and Genetic Engineering
- Law, AI, and Intellectual Property
- Neuroethics, Human Enhancement, Biomedical Innovations
- Biotechnology and Related Fields
- Zoonotic diseases and public health
- Biomedical Ethics and Regulation
- Poxvirus research and outbreaks
- Neurological disorders and treatments
- Biomedical and Engineering Education
- Parkinson's Disease Mechanisms and Treatments
- Science, Research, and Medicine
- Endoplasmic Reticulum Stress and Disease
- Cell Image Analysis Techniques
- Animal Disease Management and Epidemiology
- Prosthetics and Rehabilitation Robotics
- Research Data Management Practices
- Data-Driven Disease Surveillance
- Genetically Modified Organisms Research
- Digital and Traditional Archives Management
- RNA and protein synthesis mechanisms
- Autism Spectrum Disorder Research
- 3D IC and TSV technologies
- Genetic Neurodegenerative Diseases
National Defense University
2017-2024
United States Department of Defense
2020
United States Army Combat Capabilities Development Command
2020
U.S. Army Combat Capabilities Development Command Chemical Biological Center
2020
Gryphon Scientific (United States)
2017-2019
Parsons (United States)
2019
Berger (Canada)
2019
Johns Hopkins Center for Health Security
2017
Office of Readiness and Response
2014-2016
Georgetown University Medical Center
2016
The ER is uniquely enriched in chaperones and folding enzymes that facilitate unfolding reactions ensure only correctly folded assembled proteins leave this compartment. Here we address the extent to which localize distal sites secretory pathway are able return environment during their lifetime. Retrieval of back was studied using an assay based on capacity retain misfolded proteins. lumenal domain temperature-sensitive viral glycoprotein VSVGtsO45 fused Golgi or plasma membrane targeting...
When public health officials become aware of the first signs a disease outbreak, they need to determine few critical things as quickly possible. What’s agent? How did it get here? does spread and how can be contained? Has been seen before? If so, what was approach well work?
This year marks the Eighth Review Conference (RevCon) of Biological Toxins and Weapons Convention (BWC). At same time, ongoing international efforts to further more deeply investigate brain's complex neuronal circuitry are creating unprecedented capabilities both understand control neurological processes thought, emotion, behavior. These advances have tremendous promise for human health, but potential their misuse has also been noted, with most discussions centering on research development...
DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely person and overseas joining by video conferencing technology. The founded 2012 provides an open platform where clinicians, engineers researchers (from industry academia) can freely discuss current emerging deep brain stimulation (DBS) technologies as well the logistical ethical issues facing field. consensus among speakers that expanded its scope has been applied to multiple disorders effort...
Abstract Long‐term follow up is necessary to understand the natural history of treated Parkinson's disease (PD). The Longitudinal and Biomarker Study in PD (LABS‐PD) an observational study designed prospectively measure evolution motor non‐motor features sample promising biomarkers from early late stage illness. LABS‐PD organized on premise that cohorts completed clinical trials can be re‐recruited for long‐term up. will eventually contain multiple cohorts, but test feasibility strategy, we...
We have read with interest the recent paper by Kang, et al (2017), addressing clinical and ethical issues related to safe responsible use of CRISPR/Cas.The authors provide a number important considerations about current capabilities offered this novel gene-editing tool, including germ line editing in embryos, potential diverse uses adult human applications.The posit that tool itself does not represent threat, periodic assessment will ensure its use.We agree, but caveat: namely, any imparts...
This article examines the biosecurity and biodefense implications resulting from recent creation of horsepox virus, a noncirculating (extinct) species orthopoxvirus. Here we examine technical aspects virus synthesis conclude that orthopox experiments currently remain technically challenging-and will continue to be so, even once this work is published in scientific literature. limits potential misuse by some types nefarious actors. We also one stated purpose for recreation virus: development...
Gene synthesis providers affiliated with the International Synthesis Consortium (IGSC) voluntarily screen double-stranded DNA (dsDNA) orders over 200 bp to check for matches regulated pathogens and customers. Questions have been raised, however, about continuing feasibility effectiveness of screening. There are technical challenges (e.g., oligonucleotides tracts less than not screened) corporate costs screening high, but other dropping, so is an increasing portion operating costs). In this...
The tools of synthetic biology and the life sciences are rapidly advancing, as ability to apply classical engineering biological systems creates increasing possibilities for innovations in health medicine, materials science, energy agriculture. Intrinsic these capabilities is mounting ‘digitization biology’, genetic code its related metadata (including translated proteins, associated functions, herein referred “biodata”) amassed order engineer specific purposes. full spectrum risks with...
ABSTRACT The objective of this study was to examine a remote method for maintaining long‐term contact with Parkinson's disease (PD) patients participating in clinical studies. Long‐term follow‐up PD is needed fill critical information gaps on progression, biomarkers, and treatment. Prospective in‐person assessment can be costly may impossible some patients. Remote using mail telephone practical method. Patients enrolled the multi‐center Longitudinal Biomarker Study Disease (LABS‐PD) 2006...
Understanding the overall biosecurity and biodefense policy landscape, relationships between policies their effects on each other, mechanisms for leveraging advances in science technology to enhance defensive capabilities is crucial ensuring that strategies address long-standing gaps challenges. To date, analyses have been conducted primarily single issues, which limits of broader policies, particularly after implementation. Here we describe first-ever systems-based analysis US landscape...
The re-creation of horsepox virus, an extinct orthopoxvirus with similarity to smallpox has caused concerns in the biosecurity and biodefense communities that technical capabilities achieved could advance virus by nefarious actors. work is now published.
ABSTRACT Developments in genetics, pharmacology, biomarker identification, imaging, and interventional biotechnology are enabling medicine to become increasingly more precise “personalized” approaches assessing treating individual patients. Here we describe current scientific technological developments precision elucidate the dual-use risks of employing these tools capabilities exert disruptive influence upon human health, economics, social structure, military capabilities, global dimensions...