About
Contact & Profiles
A5085405092
Research Areas
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Multiple Myeloma Research and Treatments
Istituti di Ricovero e Cura a Carattere Scientifico
2022
The ribonuclease DIS3 is one of the most frequently mutated genes in hematological cancer multiple myeloma, yet basis its tumor suppressor function this disease remains unclear. Herein, exploiting TCGA dataset, we found that plays a prominent role DNA damage response. inactivation causes genomic instability by increasing mutational load, and pervasive accumulation DNA:RNA hybrids induces double-strand breaks (DSBs). hybrid also prevents binding homologous recombination (HR) machinery to...
10.15252/embj.2021108040
article
EN
cc-by-nc-nd
The EMBO Journal
2022-10-10
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