A5046387390- Air Quality and Health Impacts
- Energy and Environment Impacts
- Climate Change and Health Impacts
- Air Quality Monitoring and Forecasting
- Glioma Diagnosis and Treatment
- COVID-19 impact on air quality
- Immune cells in cancer
- Alzheimer's disease research and treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Genomics, phytochemicals, and oxidative stress
- Advanced Glycation End Products research
- Heat shock proteins research
- Carcinogens and Genotoxicity Assessment
- Biomarkers in Disease Mechanisms
- COVID-19 and healthcare impacts
- RNA regulation and disease
- IL-33, ST2, and ILC Pathways
- Extracellular vesicles in disease
- Particle Dynamics in Fluid Flows
- Blood Pressure and Hypertension Studies
- Pesticide Exposure and Toxicity
- Infection Control and Ventilation
- Caveolin-1 and cellular processes
- Neuroinflammation and Neurodegeneration Mechanisms
- Prion Diseases and Protein Misfolding
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2022-2024
Vita-Salute San Raffaele University
2022-2024
University of Milano-Bicocca
2012-2022
Humanitas University
2020
Oxidative stress, pulmonary and systemic inflammation, endothelial cell dysfunction, atherosclerosis cardiac autonomic dysfunction have been linked to urban particulate matter exposure. The chemical composition of airborne pollutants in Milano is similar those other European cities though with a higher PM2.5 fraction. winter fine particles (PM2.5win) are characterized by the presence nitrate, organic carbon fraction, high amount polycyclic aromatic hydrocarbons elements such as Pb, Al, Zn,...
Recent studies have suggested a link between particulate matter (PM) exposure and increased mortality morbidity associated with pulmonary cardiovascular diseases; accumulating evidences point to new role for air pollution in CNS diseases. The purpose of our study is investigate PM10sum effects on lungs extra tissues. Milano has been intratracheally instilled into BALB/c mice. Broncho Alveolar Lavage fluid, lung parenchyma, heart brain were screened markers inflammation (cell counts,...
In northern Italy, biomass burning-derived (BB) particles and diesel exhaust (DEP) are considered the most significant contributors to ultrafine particle (UFP) emission. However, a comparison between their impact on different brain regions was not investigated until now. Therefore, male BALB/c mice were treated with single or three consecutive intratracheal instillations using 50 µg of UFPs in 100 µL isotonic saline solution alone, brains collected analyzed. Proteins related oxidative stress...
Recent studies have suggested a link between inhaled particulate matter (PM) exposure and increased mortality morbidity associated with cardiorespiratory diseases. Since the response to PM1 has not yet been deeply investigated, its impact on mice lungs cardiovascular system is here examined. A repeated Milan was performed BALB/c mice. The bronchoalveolar lavage fluid (BALf) lung parenchyma were screened for markers of inflammation (cell counts, tumor necrosis factor- α (TNF- ); macrophage...
Exposure to ultrafine particles (UFPs) leads adverse effects on health caused by an unbalanced ratio between UFPs deposition and clearance efficacy. Since air pollution toxicity is first direct cardiorespiratory system, we compared the acute sub-acute of diesel exhaust (DEP) biomass burning-derived (BB) bronchoalveolar Lavage Fluid (BALf), lung heart parenchyma. Markers cytotoxicity, oxidative stress inflammation were analysed in male BALB/c mice submitted single repeated intra-tracheal...
Adverse health effects of air pollution attributed mainly to airborne particulate matter have been well documented in the last couple decades. Short term exposure, referring a few hours high ambient PM10 concentration is linked increased hospitalization rates for cardiovascular events, typically 24 h after peaks. Particulate exposure related pulmonary and diseases, with oxidative stress inflammatory status. Previously, we demonstrated that repeated intratracheal instillation PM10sum BALB/c...
Only few studies evaluated biomarkers useful for defining the cardiovascular risk of a subject in pre-clinical condition (i.e. healthy subjects). In this context we sought to determine relationships Plasminogen activator inhibitor type 1 (PAI-1), P-Selectin, Tissue Inhibitors Metalloproteinases (TIMP-1) and Cystatin-C with subclinical Target Organ Damage (TOD) normotensive normoglycemic subjects without known kidney diseases.480 blood donors participated at present analysis. TOD was as Pulse...
Abstract The biological functions of prion protein (PrP C ) and its possible interaction with other specific molecular membrane partners remain largely unknown. aim this study is to gain information on the environment PrP by analyzing lipid composition a ‐enriched subfraction, called domain, PrD . This domain was obtained immunoprecipitation detergent‐resistant microdomains (DRM) rat cerebellar granule cells under conditions designed preserve lipid‐mediated organization. electrophoretic...
Airborne ultrafine particle (UFP) exposure is a great concern as they have been correlated to increased cardiovascular mortality, neurodegenerative diseases and morbidity in occupational environmental settings. The components of diesel exhaust particles (DEPs) represent about 25% the emission mass; these surface area consequently high capacity adsorb toxic molecules, then transported throughout body. Previous in-vivo studies indicated that DEP increases pro- antioxidant protein levels...
Abstract TEM-GBM is an open-label, Phase 1/2a dose-escalation study aimed to evaluate the safety and efficacy of a myeloid cell-targeted therapy (Temferon) in up 27 newly diagnosed GBM patients with unmethylated MGMT (uMGMT). Temferon, consists autologous Hematopoietic Stem Progenitor Cells (HSPCs) genetically modified lentiviral vector deliver IFN-α2 within tumor microenvironment by Tie-2 expressing macrophages. As 21st May 2024, 24 8 cohorts received incremental doses Temferon 6 are still...
Abstract We developed an autologous hematopoietic stem cell-based platform designed to deliver IFNa, by a transcriptional and post-transcriptional control mechanism mediated miRNA target sequences, specifically into the tumor microenvironment (TME) via Tie-2 expressing monocytes (Temferon). As of Feb 2022, 3 escalating doses Temferon (0.5-2.0x106/kg) were tested across 15 newly diagnosed, unmethylated MGMT GBM patients assigned 5 cohorts. Follow-up from surgery is 6–28mo (2–25mo after...
The literature data confirm that membrane rafts are required for the proper organization of signalling pathway within lung parenchyma. physiological role appears to be closely linked their ability modulate contraction, cell proliferation, matrix protein and mediator production by airway mesenchymal airway/alveolar epithelial cells. In particular, obtained in endothelial cells suggest complexes assembled allowing a rapid, efficient regulated response extracellular stimuli. fact, presence...