A5011346574- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Cytomegalovirus and herpesvirus research
- Hematopoietic Stem Cell Transplantation
- Oral health in cancer treatment
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- Head and Neck Cancer Studies
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Prenatal Screening and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Connexins and lens biology
- Salivary Gland Disorders and Functions
- Reproductive System and Pregnancy
- Reproductive Health and Technologies
- Immune cells in cancer
- Retinal and Macular Surgery
- Ocular Infections and Treatments
- Cancer Mechanisms and Therapy
- Hormonal Regulation and Hypertension
- HER2/EGFR in Cancer Research
- Ocular Oncology and Treatments
National Cancer Institute
2021-2023
National Institutes of Health
2021-2023
Center for Cancer Research
2021-2023
Takeda (United States)
2021
Millennium Engineering and Integration (United States)
2021
National University of Singapore
2019-2020
Memorial Sloan Kettering Cancer Center
2019-2020
University of Chicago
2015-2017
NorthShore University HealthSystem
2017
Guru Teg Bahadur Hospital
2014-2015
(Val)ganciclovir (vGCV) or foscarnet (FCN) as preemptive therapy (PET) for cytomegalovirus (CMV) after allogeneic hematopoietic cell transplantation (HCT) is associated with myelosuppression and nephrotoxicity, respectively. We analyzed a cohort of CMV-seropositive (R+) HCT recipients managed preemptively at single center. The objectives our study were to (1) quantify the frequencies neutropenia acute kidney injury (AKI) through day +100 (D100) post-HCT PET discontinuation (2) assess impact...
Poly(ADP-ribose) polymerase inhibitors (PARPis) have changed the treatment paradigm in breast cancer gene ( BRCA )–mutant high-grade serous ovarian carcinoma (HGSC). However, most patients eventually develop resistance to PARPis, highlighting an unmet need for improved therapeutic strategies. Using high-throughput drug screens, we identified ataxia telangiectasia and rad3-related protein/checkpoint kinase 1 (CHK1) pathway as cytotoxic further validated activity of CHK1 inhibitor (CHK1i)...
Abstract Oral mucositis (OM) is a common complication of cancer therapy, however OM management remains unsatisfactory. There growing interest in the therapeutic potential probiotics due to positive findings its use intestinal mucositis. This study aimed determine efficacy and safety probiotic combination Lactobacillus reuteri DSM 17938 ATCC PTA 5289 strains chemotherapy-induced OM. Mice were divided into 4 groups. PBS/water PBS/LR groups comprised mice injected with PBS intraperitoneally (...
Aim: The aim of this study is to compare the metabolic and endocrinal parameters between obese nonobese polycystic ovarian syndrome (PCOS) women with normal controls. Materials Methods: was a cross-sectional comparative study. One-hundred PCOS were randomized into two groups: Group I (n = 50) II (body mass index [BMI] cutoff <23 kg/m 2 ). Fifty non-PCOS weight formed control III. Metabolic (lipid profile, blood sugar serum insulin) (serum luteinizing hormone [LH], follicle-stimulating...
Silicone oil is a commonly used tamponade agent. We report the rare complication of patient who presented with silicone in suprachoroidal space following retinal detachment repair. The was subsequently removed without any long-term complications. [ Ophthalmic Surg Lasers Imaging Retina. 2013;44:284–286.]
Background: Vitamin D, essential for bone health and overall well-being, plays a pivotal role in reproductive health. This study aimed to assess the prevalence of vitamin D deficiency among infertile women India, considering regional demographic factors. Methods: retrospective involved 34,844 seeking treatment at various centers across India. Exclusions were made with kidney or liver disorders those on medications affecting metabolism. Serum 25(OH)D levels measured through immunoassay...
Many children with excess weight and obesity struggle comorbid psychiatric disorders family stressors. These dual diagnosis presentations may be underestimated in epidemiologic surveys frequently constitute exclusion criteria childhood treatment studies. As a result, clinical paradigms for this population are lacking even multispecialty pediatric centers do not provide comprehensive services to these their families. Hence, the need article, which is preliminary exploration of possible...
e12509 Background: Approximately 63% of glioblastomas (GBMs) are characterized by overexpression the epidermal growth factor receptor (EGFR). This study was planned to assess feasibility and safety combining EGFR Inhibitor humanized MAb-nimotuzumab with temozolomide Radiotherapy in adult patients glioblastoma (GBM). Methods: Eighteen GBM were enrolled (15 male; 3 females; median age 50 years, range, 28 60 years; Karnofsky status, 90%; 70% 90%;); 7 had undergone complete resection 11 surgical...
To present a case of choroidal metastases from lung adenocarcinoma treated with intravitreal bevacizumab prior to external beam radiotherapy and systemic chemotherapy. Retrospective interventional. A 72-year-old male, no significant past ocular or medical history, presented decreased visual acuity (VA) relative scotoma in his left eye. Clinical examination revealed an elevated subretinal lesion the superotemporal macula eye fovea-involving fluid (SRF). Systemic workup metastatic primary...
Objectives: The aim was to compare the metabolic derangements in normoandrogenic and hyperandrogenic women with polycystic ovarian syndrome. Materials Methods: This cross-sectional comparative study designed ovary syndrome (PCOS). Hyperandrogenic were defined on basis of either biochemical or clinical evidence. Metabolic compared among two groups based various parameters including serum triglyceride level (≥150 mg/dl), high-density lipoprotein (≤50 fasting blood sugar (FBS) (≥100 mg%),...
Twin reverse arterial perfusion (TRAP) sequence occurs in 1 35,000 births and one percent of monochorionic twins. This condition is fatal for the recipient carries a high mortality rate pump twin. The following case reports monsterous acardiac co-twin with normal surviving INTRODUCTION: Acardiac twinning rare malformation characterized by twin perfusing an anomalous via artery-to-artery anastomosis, reversed direction flow blood to perfused fetus leading total or partial agenesis heart...
<h3>Background</h3> A deep understanding of the spatial distribution immune cells and cell-to-cell interactions within tumor microenvironment (TME) is critical for unraveling interplay between immunity growth, especially in context variable responses to checkpoint blockade (ICB) therapy <h3>Methods</h3> Here, we report application multiplex imaging new computational methods extraction patterns TME analysis biopsy samples recurrent ovarian cancer patients enrolled a phase II study PARP...
A 10-year-old previously healthy Caucasian boy was referred for evaluation of bilateral loss vision with abnormal appearing optic nerves. Two months before the referral, patient started to exhibit a decrease in both at near and distance difficulty reading books viewing chalkboard school. One month prior seen by his primary care physician complaint intermittent headaches, which varied severity, occurring as frequently daily. The had been taking ibuprofen regularly alleviate pain. Vital signs...