A5067539136- Advancements in Transdermal Drug Delivery
- Neuroscience and Neuropharmacology Research
- Advanced Drug Delivery Systems
- Renin-Angiotensin System Studies
- Ion channel regulation and function
- Retinal Development and Disorders
- Bee Products Chemical Analysis
- Neurobiology and Insect Physiology Research
- Dermatology and Skin Diseases
- Ocular Surface and Contact Lens
- Cardiovascular Disease and Adiposity
- Retinopathy of Prematurity Studies
- Neural dynamics and brain function
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Memory and Neural Mechanisms
- Retinal Diseases and Treatments
- Hormonal and reproductive studies
University of Iowa
2016-2024
Activation of the brain renin-angiotensin system (RAS) stimulates energy expenditure through increasing resting metabolic rate (RMR), and this effect requires simultaneous suppression circulating and/or adipose RAS. To identify mechanism by which peripheral RAS opposes RMR control RAS, we examined mice with transgenic activation (sRA mice). sRA exhibit increased flux in inguinal tissue, is attenuated angiotensin II type 2 receptor (AT2) activation. AT2 adipocytes norepinephrine-induced...
Objectives: Oxybutynin (OXB), an anticholinergic drug used to treat overactive bladder, exhibits increased permeation during and following occlusion, or covering, of a topical gel application1. Occlusion semisolid product treated dermal areas can increase the drugs through skin due stratum corneum hydration, surface temperature, and/or blood flow2. Removing occlusion further alter permeation, formulation metamorphosis supersaturation residual layer as water evaporates. The purpose this...
Transdermal delivery of naltrexone (NTX) can be enhanced using microneedles, although micropores generated this way reseal by 48 h in humans, which prevents further drug from a formulation. Poloxamer 407 (P407) is thermosensitive polymer that may extend microneedle-assisted NTX time creating an situ gel depot the skin. We characterized gelation temperature, release, and permeation P407 gels containing 7% NTX-HCl. To investigate microneedle effects on NTX-HCl permeation, porcine skin was...
Naltrexone (NTX) can be transdermally delivered using microneedles (MN) to treat opioid and alcohol misuse disorders, but delivery is blunted by rapid in vivo micropore closure. Poloxamer (P407), a thermosensitive biocompatible hydrogel, sustains NTX through MN-treated skin generating drug depot within the micropores. Optimizing P407 formulations could maintain sustained after closure while reducing required patch sizes, which would more discreet preferred most patients. Here we developed...
Ca2+-binding protein 1 (CaBP1) is a Ca2+-sensing similar to calmodulin that potently regulates voltage-gated Ca2+ channels. Unlike calmodulin, however, CaBP1 mainly expressed in neuronal cell-types and enriched the hippocampus, where its function unknown. Here, we investigated role of hippocampal-dependent behaviors using mice lacking expression (C-KO). By western blot, largest splice variant, caldendrin, was detected hippocampal lysates from wild-type (WT) but not C-KO mice. Compared WT...
Abstract In retinal diseases such as age-related macular degeneration (AMD) and choroideremia, a key pathophysiologic step is loss of endothelial cells the choriocapillaris, dense vascular bed required for maintaining health function retina. As such, repopulation choroidal vasculature early in disease process may halt progression. Prior studies have shown that injection donor suspension results significant cellular efflux poor cell survival. goal this study was to develop hydrogel system...