A5009610542- Autism Spectrum Disorder Research
- Transcranial Magnetic Stimulation Studies
- Genetics and Neurodevelopmental Disorders
- Neuroendocrine regulation and behavior
- Obsessive-Compulsive Spectrum Disorders
- Child Development and Digital Technology
- Attention Deficit Hyperactivity Disorder
- Functional Brain Connectivity Studies
- Neuroscience of respiration and sleep
- Genomics and Rare Diseases
- Infant Health and Development
- Genomic variations and chromosomal abnormalities
- Eating Disorders and Behaviors
- Family and Disability Support Research
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Virology and Viral Diseases
- Muscle activation and electromyography studies
- Neuroscience and Neural Engineering
- Behavioral and Psychological Studies
- Neural dynamics and brain function
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Vaccine Coverage and Hesitancy
- Intraoperative Neuromonitoring and Anesthetic Effects
University of Minnesota
2014-2025
National Institutes of Health
2023-2024
National Institute of Mental Health
2023-2024
University of Minnesota System
2018-2023
Brookhaven Technology Group (United States)
2021
University of Illinois Chicago
2012-2016
Institute of Behavioral Sciences
2014
Abstract Autism spectrum disorder (ASD) is a genetically heterogeneous condition, caused by combination of rare de novo and inherited variants as well common in at least several hundred genes. However, significantly larger sample sizes are needed to identify the complete set genetic risk factors. We conducted pilot study for SPARK (SPARKForAutism.org) 457 families with ASD, all consented online. Whole exome sequencing (WES) genotyping data were generated each family using DNA from saliva....
Abstract Background Access to “big data” is a boon for researchers, fostering collaboration and resource-sharing accelerate advancements across fields. Yet, disentangling complex datasets has been hindered by methodological limitations, calling alternative, interdisciplinary approaches parse manifold multi-directional pathways between clinical features, particularly highly heterogeneous autism spectrum disorder (ASD). Despite long history of male-bias in ASD prevalence, no consensus reached...
Individuals with Autism Spectrum Disorder (ASD) have been shown to atypical scanning patterns during face and emotion perception. While previous studies characterized ASD using eye-tracking data, this study examined whether the use of eye movements combined task performance in facial recognition could be helpful identify individuals ASD. We tested 23 subjects 35 controls a Dynamic Affect Recognition Evaluation (DARE) that requires an individual recognize one six emotions (i.e., anger,...
Background: There are limited treatments available for autism spectrum disorder (ASD). Studies have reported significant associations between the receptor genes of oxytocin (OT) and vasopressin (AVP) ASD diagnosis, as well as, ASD-related phenotypes. Researchers also found manipulation these systems affect social repetitive behaviors, core characteristics ASD. Consequently, research involving oxytocin/vasopressin pathways intervention targets has increased. Therefore, further examination...
The aim of this study was to determine the impact COVID-19 pandemic on access rehabilitation therapies and changes in therapy physical mental well-being children with motor impairment their caregivers.Caregivers younger than 18 yrs childhood-onset (primarily cerebral palsy) completed an anonymous survey through online platform REDCap between May 5 July 13, 2020.The by 102 participants. Before pandemic, 92 (90%) were receiving one or more therapies; at time surveyed, 55 (54%) any (P < 0.001)....
Abstract Ataxin 2 binding protein 1 ( A2BP1 aka FOX1 , RBFOX1 ) is an RNA responsible for regulation of pre‐mRNA splicing events in a number critical developmental genes expressed muscle, heart and neuronal cells [Shibata et al. (2000); Mamm Genome 12:595–601; Jin (2003); EMBO J 22:905–912; Underwood (2005); Mol Cell Biol 25:10005–10016]. Rare copy abnormalities have been previously associated with cognitive impairment, attention deficit disorder autism [Martin (2007); Am Med Gen Part B...
CD 38 encodes a ligand in the oxytocin signaling pathway. Some single nucleotide polymorphisms this gene have been associated with low serum levels autism spectrum disorder ( ASD ) patients. Oxytocin disruption has hypothesized to account for features of , including impaired communication and social behavior, based on animal studies. Recent human studies shown administration improving emotion recognition, promoting auditory processing stimuli In addition its role signaling, is involved...
There has been increasing interest in oxytocin (peptide: OT, gene: OXT) as a treatment pathway for neurodevelopmental disorders such Autism Spectrum Disorder (ASD). Neurodevelopmental affect functional, social, and intellectual abilities. With advances molecular biology, research connected multiple gene regions to the clinical presentation of ASD. Studies have also shown that neuropeptide hormones OT arginine vasopressin (AVP) influence mammalian social territorial behaviors may potential...
Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder (NDD) with high rate of comorbidity. The implementation eye-tracking methodologies has informed behavioral and neurophysiological patterns visual processing across ASD comorbid NDDs. In this study, we propose machine learning method to predict measures two core characteristics: impaired social interactions communication, restricted, repetitive, stereotyped behaviors interests. Our extracts features from task...
Relationships between parental broader autism phenotype ( BAP ) scores, gender, selective serotonin reuptake inhibitor SSRI treatment, (5 HT levels, and the child's symptoms were investigated in a family study of spectrum disorder ASD ). The Broader Autism Phenotype Questionnaire BAPQ was used to measure 275 parents. Fathers not taking SSRIs F ‐ ; n = 115) scored significantly higher on Total Aloof subscales compared mothers receiving treatment M 136.) However, + 19) than those medication...
Abstract Background Comprehensive Behavioral Intervention for Tics (CBIT) is a first-line treatment tic disorders that aims to improve controllability over tics an individual finds distressing or impairing. However, it only effective approximately half of patients. Supplementary motor area (SMA)-directed neurocircuitry plays strong role in inhibition, and activity this region thought contribute expression. Targeted modulation SMA using transcranial magnetic stimulation (TMS) may increase...
Abstract Noninvasive brain stimulation (NIBS) techniques, including repetitive transcranial magnetic (rTMS) and direct current (tDCS), have recently emerged as alternative, nonpharmacological interventions for a variety of psychiatric, neurological, neurodevelopmental conditions. NIBS is beginning to be applied in both research clinical settings the treatment core associated symptoms autism spectrum disorder (ASD) social communication deficits, restricted behaviors, irritability,...
Autism spectrum disorder (ASD) is a genetically heterogeneous condition, caused by combination of rare de novo and inherited variants as well common in at least several hundred genes. However, significantly larger sample sizes are needed to identify the complete set genetic risk factors. We conducted pilot study for SPARK (SPARKForAutism.org) 457 families with ASD, all consented online. Whole exome sequencing (WES) genotyping data were generated each family using DNA from saliva. identified...