A5004032519- Ovarian function and disorders
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Sirtuins and Resveratrol in Medicine
- Antioxidant Activity and Oxidative Stress
- Hormonal and reproductive studies
- Biological and pharmacological studies of plants
- Reproductive System and Pregnancy
- Medicinal Plant Pharmacodynamics Research
University of South China
2020-2023
Central South University
2023
Shaoyang University
2022
Scope Insulin resistance (IR) has a close relationship with the main clinical manifestations of patients PCOS; hence, research and development new drugs to treat PCOS by improving IR is desiderate task at present. Resveratrol (RES) possesses variety beneficial pharmacological functions, such as antioxidation, anti-inflammatory, regulating glucose, lipid metabolism. However, whether RES could improve underlying mechanisms remained unclear in PCOS. Methods results SD rats received high-fat...
Scope Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that can cause infertility; however, the underlying mechanisms remain ill‐defined, there are no available drugs or strategies for treatment of PCOS. This study examined therapeutic effect resveratrol in rat model Methods Results PCOS induced rats by administration letrozole high fat diet to determine whether has protective effect. Oral significantly decreased body weight, as well serum levels testosterone...
Diabetes mellitus (DM), a chronic metabolic disease, severely impairs male reproductive function. However, the underpinning mechanisms are still incompletely defined, and there no effective strategies or medicines for these lesions. Icariin (ICA), main active component extracted from Herba epimedii, is flavonoid traditionally used to treat testicular dysfunction. Whether ICA can improve dysfunction caused by DM its underlying unclear. In this study, employing metformin as comparative group,...
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovaries. In this study, we induced young-adult PCOS rat model oral administration of letrozole combined with high-fat diet then treated mogroside V (MV) to evaluate the protective effects MV on follicle development in rats. (600 mg/kg/day) not only significantly reduced body weight weight, but also attenuated disrupted estrous cycle decreased level...
Spermatogenic dysfunction is one of the major secondary complications diabetes; however, underlying mechanisms remain ill-defined, and there no available drug or strategy for radical treatment diabetic spermatogenic dysfunction. Therefore, objective this study to investigate protective effects nicotinamide mononucleotide (NMN) on testicular function in streptozotocin (STZ)-induced mice. The results show that oral administration NMN significantly increases body testis weight number sperms....