A5022699509- Carcinogens and Genotoxicity Assessment
- Dye analysis and toxicity
- Human Health and Disease
- Radioactive element chemistry and processing
- Biochemical Analysis and Sensing Techniques
- Consumer Attitudes and Food Labeling
- Chemical Synthesis and Characterization
- Structural Analysis and Optimization
- Esophageal and GI Pathology
- Nanoparticles: synthesis and applications
- Air Quality and Health Impacts
- Pancreatic and Hepatic Oncology Research
- Material Properties and Applications
- Chemical Reactions and Isotopes
- Effects and risks of endocrine disrupting chemicals
- Industrial Gas Emission Control
- Structural Analysis of Composite Materials
- thermodynamics and calorimetric analyses
- melanin and skin pigmentation
- Minerals Flotation and Separation Techniques
- Indoor Air Quality and Microbial Exposure
- bioluminescence and chemiluminescence research
- Synthesis of Organic Compounds
- Mitochondrial Function and Pathology
- Polymer Science and PVC
Federal Medical-Biological Agency
2022-2024
Center for Strategic Research
2018-2023
Ural State Forestry Engineering University
2018-2022
Ministry of Health of the Russian Federation
2015-2019
Ufa Research Institute of Occupational Health and Human Ecology
2019
Russian Academy of Sciences
2001-2005
Central Research Institute of Structural Materials Prometey
1996
Moscow Technological Institute
1973-1986
Food additives and food colours, in particular, are becoming more widespread all countries. The review is devoted to a least studied problem of synthetic colours safety assessment approved for use the Russian Federation an analysis their genotoxic effect (mechanisms, methods determination results studies on various living objects). Results half-century study genotoxicity demonstrated among there were none them which unambiguous research obtained, what allows us conclude about possibility...
The article presents the results of second fragment complex genetic and psychological examination 177 students chemical (CD) economic (ED) departments Russian D.I. Mendeleev Chemical-Technological University. design whole work included analysis conditions, socio-economic characteristics quality life, multi-parameter testing (177 students) buccal micronucleus cytome assay (146 students). first stage study showed state health emotional not to be affected by factors that were taken into...
Introduction. Food azo dye Tartrazine (E102) is widely used in the production of food, pharmacological and cosmetic products. Despite approval for use, interest a comprehensive assessment impact food colours, especially synthetic ones, on health continues unabated. The analysis literature evaluating genotoxicity vivo studies revealed some inconsistencies results, that showed possibility to test retail colouring one recommended tests. Materials methods. (produced India, purity 88.37%) was...
There are presented results of the cytome analysis epithelium buccal mucosa in 167 children aged 5-7 years, permanently residing city Magnitogorsk and visiting municipal kindergartens. Frequencies main indices genotoxic toxic effects were: cells with micronuclei - 0.29±0.04 %, protrusions ofnuclei 1.47±0.17 double nuclei -1.96±0.13 two 3,28±0,16 perinuclear vacuole 9.66±0.86 pycnosis nucleus 4.60±0.31 per 1000 cells, karyorrhexis 0.86±0.15per lysis 54.34±3.90 condensed chromatin 10.59±1.35...
Introduction. Polymer materials currently used in drinking water supply practice consist of a polymer base and additional chemicals. During use, release toxic chemicals, including additives residual monomers. Even if all components mixture are present quantities that do not individually cause the expected adverse effects, population may be adversely affected by chronic exposure to low concentrations, which act additively produce greater cumulative toxicity. The article presents results study...
Introduction. Accounting for micronuclei (MN) in the epithelium of buccal mucosa is widely used to identify human exposure genotoxic factors. Cytome analysis makes test more sensitive detect exposure, but it remains difficult attribute changes individual indices toxicity or genotoxicity. We hypothesized that frequencies different forms nuclear abnormalities cells degrees maturity could promote our understanding biological meaning shifts these indicators. Materials and methods. A cytome was...
The possibility of using an intercalated montmorillonite for separation cesium and strontium radionuclides from aqueous solutions was studied in this work. distribution coefficients Cs Sr were Kd = (2.5 ± 0.2)×103 L/kg. time achieving sorption equilibrium did not exceed 10 minutes that indicates the external diffusion as limiting stage sorption. Adsorption occurs due to formation a monolayer pores sorbent it can be described by Langmuir equilibrium. Separation result poly layer adsorption...
To identify the mutagenic danger of various factors for humans often use two micronuclear tests - in peripheral blood lymphocytes cultivated with Cytochalasin B and buccal mucosa epithelial cells. The last test is non-invasive it incomparably easier collection fixation an Apparently, therefore, there a sufficient number publications results meta-analysis comparisons these tests, which prove possibility their substitution. aim our work to verify hypothesis interchangeability micronuclei (MT)...
Introduction. This publication presents the third fragment of a comprehensive multi-parameter pilot study to create methodology for assessing open-air odor’ impact on human’s adaptive potential. The was carried out in little town (50 thousands inhabitants), mainly food industry and agro-industrial complex work, but enterprises 1-2 classes danger are absent. Air emissions from operating have specific odor that causes complaints inhabitants. Materials methods. effects genome instability (EGI)...
Aim. To explore the possibility for a temporary compression of perforation hole by endobiliary stenting in close proximity papillotomy anastomosis. Materials and methods. On basis clinical observations, two technologies were compared experimentally case retro-duodenal development through pockets hepaticopancreatic ampulla trial cannulation after pre-scattering: self-expanding endoprosthesis tight frame with several plastic stents. Results. Closure is provided due to stent, when it occurs 2mm...
The publication represents the first fragment of large comparative study, directed to investigation factors which negatively influenced state health and emotional sphere students from Chemical Faculty (CF, 102 persons) economic (EF, 68 faculties same university. For this goal, genetical, psychological sociological was included into study. block standard scales, detecting levels expression social adoption, alarm, overfatigue interpersonal relations as well subjective welfare scale, are used...
Introduction. Analysis of literature has shown genotoxicants (mutagens and carcinogens) to be present in the atmospheric emissions pulp paper industry (PPI). Moreover, among PPI workers from different countries, there was identified an additional risk cancer, which suggests its high probability residents cities where is located. The recognized index genotoxic effects increased level genome instability, determined, particular, micronucleus test. scope study - comparative analysis genomic...
Introduction. Sunset Yellow food azo dye (E110) is actively used to impart yellow-orange hues food, pharmacological and cosmetic products. The control of consumption the quality synthetic dyes themselves, worries researchers from various countries, including countries producing this segment additives, which are also in domestic industry. Therefore, safety assessment dyes, genotoxicity, relevant. Materials methods. Genotoxicity (produced India, purity being 90,46%) was studied micronucleus...
Introduction. Azorubine E122 (Carmoisine, Food Red 3) monoazo dye is used in the manufacture of desserts, caramels, sweets, marmalades, ice cream, alcoholic and non-alcoholic drinks, etc. The safety assessment food additives includes study genotoxic potential. At same time, for substances with a high or small but long-term exposure (including additives), vivo tests are required. Materials methods. activity aqueous solutions synthetic azo dyes Azorubin was studied by micronuclear method on...
Introduction. Food monoazo dye E124 Ponceau 4R is used in the food, pharmaceutical, and cosmetic industries. An analysis of available data on evaluation genetic safety based main marker events genotoxicity revealed their inconsistency, possibly associated with quantitative and/or qualitative differences studied samples for impurities. The aim work to evaluate mutagenic activity micronucleus test mice several commercial present domestic market. Materials methods. Three from different...