Summary As humic acid (HA) substances have antiphlogistic, adsorptive, antitoxic and antimicrobial properties, we studied the possible effects of Farmagülatör ® , an organic HA preparation, on rat performance, nutrient retention, ileal histomorphology hydroxyproline (HP) content ileum in two experiments. In experiment 1, 48 male Wistar albino rats were allotted to three dietary treatments. Each was randomly assigned four cages, each with rats. The treatments consisted a control diet (C) no...

The present study aimed to investigate the possible postnatal effects on liver, kidney and testicular tissues of offspring rats given diclofenac sodium (DS) during pregnancy.At beginning experiment, 80 (20 males 60 females) were raised together for mating purposes. At end, 50 pregnant obtained used as experimental subjects. All divided into 2 groups, each with 25 rats. control group received physiological serum, 1 cm3/kg live weight per day, treatment injected DS, mg/kg day from 5th 20th...

The aim of this study is to investigate the growing caecum and vermiform appendix during fetal period in human fetuses relation between shape localization appendix.40 male 40 female externally normal-looking were studied 10 weeks gestation subdivided into 1st, 2nd, 3rd trimesters full-term fetuses. parameters interest included covering with peritoneum, (long tube, symmetric saccule, asymmetric extremely large right side--atypical), axial length width appendix, meso-appendix.There was a...

In this study, we aimed to investigate the possible effect of melatonin on morphological changes in liver induced by magnetic fields exposure. Thirty albino young male Wistar Albino rats were used study. They divided into 3 groups. Control group (C) (n: 10) received daily intraperitoneal injections saline (0.1 ml/100 g) containing 5% ethanol for two weeks. Only field exposed (MF) 10); only had physiologic Magnetic and treated (MF+m) was dissolved with further dilution physiological saline....

This study aimed to investigate the histopathological effects of thyroidectomy on both immature and adult rat testes.Male albino Wistar rats, 4 weeks old weighing between 45 55 g, were used for this study. The experimental groups as follows: 2-week control group (group I); II); 4-week III); IV); 6-week V), VI). included sham-operated untreated rats. In II, IV VI, total was performed under ether anesthesia in all rats at age. killed 2nd, 4th 6th weeks, respectively, following thyroidectomy....

Tenoxicam is a non-steroidal antiinflammatory drug, which has antipyretic and effects. Though it known that the major side effect of drugs on gastrointestinal tract liver, there have been few studies regarding effects tenoxicam. In this study, we aimed to investigate whether tenoxicam deleterious liver tissue using immunohistochemical staining biochemical analysis.A total 30 male Wistar albino rats were included in study. Animals equally randomly divided into three groups as follows: Group I...

Doxorubicin (DOX) is a potent chemotherapeutic agent and has toxic effects on various organs, including the liver. In current study, we aimed to investigate of bone-marrow-derived mesenchymal stem cell (BM-MSC) administration DOX-induced hepatotoxicity in rats. 24 Wistar-albino rats were divided into three groups: Control, DOX, DOX+MSC. DOX (20 mg/kg) was administered group. + MSC group, BM-MSCs (2 × 106 ) given through tail vein following administration. led significant structural liver...

To determine the effect of fluoride ingested during development period on number odontoblast cells using stereological methods. Materials and methods: A total 56 freshly extracted primary first second molar teeth were used, obtained from children (aged between 9 11 years) requiring dental extractions for clinical reasons. Following histological procedures, longitudinal tooth sections, 25 µm thick, stained with hematoxylin eosin. The was estimated optical fractionator method a workstation....

Hypericum perforatum (HP) is a herbal product used in the treatment of depression, but its harm on fetus has not been established. This study investigated effects HP according to fetal clinical, morphologic, and histologic findings. Study design an animal study.Fifty-four 4-5-month-old female Wistar rats were divided into three groups: control, 100 mg/kg HP, 300 HP. using drinking water was started one week before mating ended with delivery pups.HP exposure conception diminished pregnancy...

Trimethobenzamide (TMB) has a pregnancy category C labeling. Tardive dyskinesia and gastrointestinal involvement in neonates were not described earlier. We aimed to investigate neurological, developmental, hepatic effects of TMB.Ten 10 pregnant rats divided into two groups. During pregnancy, Group I (control) injected with saline; II TMB (5 mg/kg/day). After delivery, experiments planned: experiment 1 (neuro) Experiment 2 (hepatic). Control groups contained offsprings delivered from mothers:...

A developing embryo is exposed to side effects of diclofenac sodium (DS), a commonly used non-steroidal anti-inflammatory drug, since women may incidentally become pregnant while receiving DS therapy. Several adverse have been clearly established. However, the prenatal exposure on cerebellum especially are unclear for granular cells. In this study, we investigated total number granule cells in control and DS-treated groups male rats using optical fractionator technique. (Voltaren, 75 mg/3...

Abstract Objective Statins and Paracetamol have widespread use in clinic both drugs possess similar side effects; therefore, we investigated if drug-interaction occurs when the combination of these two is used during therapy. Materials methods A total 32 (12–15 months old) grown-up male rats were divided into four groups: Control group, RSV group (10 mg/kg Rosuvastatin/daily), APAP (50 Paracetamol/5 days/weekly), RSV+APAP Rosuvastatin/daily+50 days/weekly). At end 8 weeks chronic treatment,...