A5019439623- Sesquiterpenes and Asteraceae Studies
- Natural product bioactivities and synthesis
- Plant Toxicity and Pharmacological Properties
- Neurobiology and Insect Physiology Research
- Phytochemistry and Biological Activities
- Plant biochemistry and biosynthesis
- Allelopathy and phytotoxic interactions
- Free Radicals and Antioxidants
- Sirtuins and Resveratrol in Medicine
- Insect Pest Control Strategies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Bioactive natural compounds
- Phytochemistry and Bioactive Compounds
- Antioxidant Activity and Oxidative Stress
- Botanical Research and Chemistry
- Pharmacological Effects of Natural Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Plant and animal studies
- Plant-derived Lignans Synthesis and Bioactivity
- Essential Oils and Antimicrobial Activity
- Phytochemical Studies and Bioactivities
- Analytical Chemistry and Chromatography
- Photochromic and Fluorescence Chemistry
- Synthetic Organic Chemistry Methods
- Chemical synthesis and alkaloids
Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
2012-2024
University of Chemistry and Technology, Prague
2016
Czech Academy of Sciences
1997-2015
Slovak Academy of Sciences
2010-2012
Institute of Plant Protection
1984-1991
University of British Columbia
1989-1991
Institute of Organic Chemistry
1990
New York Academy of Medicine
1984
Medicina
1984
KTH Royal Institute of Technology
1979
Abstract The antifeedant activity of a series lignan lactones, hemiacetals, ethers, and alcohols derived from yatein cubebin, together with structurally related phenylpropanoids phenolics possessing methylenedioxyphenyl (piperonyl) moiety, was tested against selected stored products pests: Sitophilus granarius L. (Coleoptera: Curculionidae), Tribolium confusum Duv. Tenebrionideae), Trogoderma granarium Ev. Dermestridae). relation between molecular structure examined implication the piperonyl...
Fourteen minor ecdysteroid components were isolated and identified from the roots of Leuzea carthamoides (Willd.) DC. Two them are new phytoecdysteroids: leuzeasterone ( 1 ) a six-member side-chain lactone, (24 Z )-29-hydroxy-24(28)-dehydromakisterone C 4 structurally related sitostane type analogue assumed biogenetic precursor . The next one, 5α-20-hydroxyecdysone 6 ), is rare A/B-ring trans-annelated epimer most common phytoecdysteroid 20-hydroxyecdysone. Further compounds: makisterone 3...
The potencies of 19 ecdysteroids are compared in the B11 bioassay, which reflects affinity binding site Drosophila melanogaster ecdysteroid receptor. compounds tested represent either natural products isolated from plants (phytoecdysteroids) or fungi (mycoecdysteroids) synthetic analogues based on insect metabolites (zooecdysteroids). None showed any antagonistic activity, but all possessed quantifiable agonistic activity. All mycoecdysteroids were less potent than major ecdysteroid,...
The structure of yatein isolated from Libocedrus yateensis has been determined as (2 R , 3 )-2-(3,4,5-trimethoxybenzyl)3-(3,4-methylenedioxybenzyl)butyrolactone ( Ia ). assignment individual signals the 1 H NMR spectrum and further lignans 2,3-dibenzyl-butyrolactone type is discussed supported by use a lanthanide shift reagent mass spectrometry deuterated derivatives IIa IIb . A method determination absolute configuration centres C (2) (3) these 2,3-dibenzylbutyrolactone on basis combination...
Three new and five known sesquiterpene lactones were isolated from the roots of Laser trilobum (L.) Borkh. Chemical identity compounds structural analysis ones determined by HR MS NMR spectroscopy. The two lactones: 2-acetoxytrilobolide 2-hydroxy-10-deacetyltrilobolide belong to guaianolide type, third one, eudeslaserolide, biogenetically related eudesmanolide type. Both types, together with their biogenetic precursor germacranolide type (laserolide) are present in L. trilobum, as well...
It has been demonstrated that pterostilbene inhibits reactive oxygen species production in neutrophils vitro . However, little is known about its effects on during inflammation vivo In this study, the effect of neutrophil activity was investigated experimental arthritis model. Lewis rats were injected by a single intradermal injection heat-killed Mycobacterium butyricum Freund’s adjuvant to develop arthritis. Another group arthritic animals received 30 mg/kg, daily, p.o. The number and blood...
Resveratrol-3,5,4'-trihydroxystilbene-possesses antioxidant activities in vitro. It dose-dependently inhibited the generation of peroxyl, hydroxyl, peroxides, and lipid peroxidation products cell free systems. Oxidative burst whole human blood stimulated with PMA, fMLP, OpZ, A23187 was a concentration-dependent way, indicating suppression both receptor nonreceptor activated chemiluminescence by resveratrol. Results from isolated neutrophils revealed that resveratrol active extracellularly as...