A5031776063- Supramolecular Self-Assembly in Materials
- Advanced biosensing and bioanalysis techniques
- Glycosylation and Glycoproteins Research
- Research on Leishmaniasis Studies
- DNA and Nucleic Acid Chemistry
- Polydiacetylene-based materials and applications
- Alzheimer's disease research and treatments
- Crystallization and Solubility Studies
- Liver Disease Diagnosis and Treatment
- Computational Drug Discovery Methods
- X-ray Diffraction in Crystallography
- Parasites and Host Interactions
- Airway Management and Intubation Techniques
- Carbohydrate Chemistry and Synthesis
- Nanoparticle-Based Drug Delivery
- Foreign Body Medical Cases
- Asymmetric Synthesis and Catalysis
- Biochemical Analysis and Sensing Techniques
- Brucella: diagnosis, epidemiology, treatment
- Synthetic Organic Chemistry Methods
- Seaweed-derived Bioactive Compounds
- Pancreatitis Pathology and Treatment
- RNA and protein synthesis mechanisms
- Trypanosoma species research and implications
- Tracheal and airway disorders
Karolinska Institutet
2014-2024
Peerless Hospital & B.K.Roy Research Centre
2017-2024
Bose Institute
2016-2020
Science and Engineering Research Board
2020
Amity University
2017-2019
Chimie et Biologie des Membranes et des Nanoobjects
2018
Institut Européen de Chimie et Biologie
2016
Université de Bordeaux
2016
Institut Polytechnique de Bordeaux
2016
National Institute of Pharmaceutical Education and Research
2014-2015
G-quadruplex (G4) DNA structures are prevalent secondary implicated in fundamental cellular functions, such as replication and transcription. Furthermore, G4 directly correlated to human diseases cancer have been highlighted promising therapeutic targets for their ability regulate disease-causing genes, e.g., oncogenes. Small molecules that bind stabilize these thus valuable from a perspective helpful studying the biological functions of structures. However, there hundreds thousands motifs...
Although dilatation is the treatment of choice for most patients with benign oesophageal strictures, there little information on its efficacy and safety in corrosive strictures. Of 123 adults strictures treated by endoscopic dilatation, 52 (42.3%) had after ingestion 39 (31.7%) peptic Treatment was considered adequate if lumen could be dilated to 15 mm complete relief dysphagia. If dysphagia recurred initial stricture again up mm. Initial 93.6% this success rate comparable that group (100%,...
Intertwining triple helical nanofibers with an overall handedness have been formed from self-assembling chiral benzene-1,3,5-tricarboxamides 1, 2 and 3, whereas the achiral benzene-1,3,5-tricarboxamide 4 upon self-association gives rise to straight without any twist transmission electron microscopy images of compounds clearly demonstrate that can be reversed by using enantiomeric building blocks.
Alzheimer's disease (AD), an age related neurodegenerative disorder, threatens to become a major health-economic problem. Assembly of 40- or 42-residue amyloid β-peptides (Aβ) into neurotoxic oligo-/polymeric β-sheet structures is important pathogenic feature in AD, thus, inhibition this process has been explored prevent treat AD. The C-terminal part plays role Aβ aggregation, but most aggregation inhibitors have targeted the central region around residues 16−23. Herein, we synthesized...
Alzheimer's disease (AD), an age-related neurodegenerative disorder, is the most common form of dementia, and seventh-leading cause death in United States. Current treatments offer only symptomatic relief; thus, there a great need for new with disease-modifying potential. One pathological hallmark AD so-called senile plaques, mainly made up β-sheet-rich assemblies 40- or 42-residue amyloid β-peptides (Aβ). Hence, inhibition Aβ aggregation actively explored as option to prevent treat AD....
Construction of various nanostructures using suitable self-assembling molecular building blocks is a challenging issue. Moreover, controlling the formation specific nanostructure from by tuning pH solution interesting. The present study demonstrates pH-responsive nanostructural transformation water-soluble tripeptide nanotubes to nanovesicles. In acidic (pH 4.3–5.5), hollow nanotubular structures have been observed, while at 6.5 (nearly neutral), both and nanovesicles coexist uniformly. With...
The surface of a nanofiber that is formed from self-assembling pseudopeptide has been decorated by gold and silver nanoparticles are stabilized dipeptide. Transmission electron microscopic images make the decoration visible. In this paper, new strategy mineralizing based with use two-component nanografting method described.
Lectins are highly important biomolecules to study several biological processes. A novel α-D-glucose/mannose specific lectin was isolated from the seeds of litchi fruits (Litchi chinensis) and its various biophysical biochemical properties were studied.Purification done by successive Sephadex G 100 Con A-Sepharose 4B affinity chromatography. SDS-PAGE, Surface Plasmon Resonance (SPR), steady state absorbance, fluorescence, time-correlated single-photon counting, circular dichroism antibiofilm...
The development of Zn2+-dependent dimethyl-dppz-PNA conjugates (PNAzymes) as efficient site-specific artificial ribonucleases enables rapid sequence-specific degradation clinically relevant RNA target sequences, but the significance RNA/PNAzyme sequence and structural demands for identification novel targets are not fully understood. In present study, we investigated influence variation in recognition arms complex on cleavage activity enzymes. base pairs closing 3-nucleotide bulge region...
The cirrhotic condition of the liver has long been acknowledged as preface to cancer. desialylation status serum acute phase protein, haptoglobin, introduced a new diagnostic analyte for cirrhosis. reliability this molecule evaluated in 30 cirrhosis patients having history earlier viral hepatitis C (HCV-LC). A novel enzyme linked lectinosorbent assay developed coupled with plasmon mechanism gold nanoparticle aggregation colorimetric read out which can visually distinguish from normal healthy...
Esophageal perforation is a dreaded complication of anterior cervical spinal surgery. A 52-year-old diabetic man had undergone surgery for C6-C7 disc prolapse and developed spiking fever with chills rigor on the 7th postoperative day. No cause could be found out but CT scan thorax done in course investigations revealed pneumomediastimum. The patient succumbed 10th day after Autopsy death to mediastinitis following iatrogenic esophageal perforation. second patient, 53 years age, C5-C6...
Purpose: After the extensive resistance of first line antimonial drugs, paromomycin, broad-spectrum antibiotic has become treatment choice against visceral leishmaniasis, fatal tropical disease. However, unfavorable distribution in intracellular compartment macrophage, prolonged parenteral administration procedure and toxicity limit use paromomycin. Lack availability specific delivery system also makes this drug unsafe. Thus, a nontoxic formulation paromomycin is an urgent need. Materials...
The morbidity and mortality associated with asthma make it a worldwide health concern. Corticosteroid therapy is the most popular method to treat asthma, but yoga has been identified as an alternative expensive drugs. A systematic review of studies meeting following criteria presented: ( a) be published in English language; b) included CINAHL, Medline, or Alt HealthWatch; c) between years 1972 2012; d) include intervention; e) use any quantitative study design; f) measures one outcomes:...