A5084905754- Hair Growth and Disorders
- Pericarditis and Cardiac Tamponade
- Infective Endocarditis Diagnosis and Management
- Myasthenia Gravis and Thymoma
- Dermatology and Skin Diseases
- Advanced Statistical Methods and Models
- Statistical Methods and Bayesian Inference
- Infectious Diseases and Tuberculosis
- Cardiac Structural Anomalies and Repair
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Statistical Methods and Inference
- Viral Infections and Immunology Research
- Statistical Methods in Clinical Trials
- Skin and Cellular Biology Research
- Blood Pressure and Hypertension Studies
- Contact Dermatitis and Allergies
- Dermatologic Treatments and Research
- Statistical Distribution Estimation and Applications
- melanin and skin pigmentation
- Medicine and Dermatology Studies History
- Hormonal Regulation and Hypertension
- Bayesian Methods and Mixture Models
- Educational Assessment and Pedagogy
- HIV/AIDS oral health manifestations
University of Cape Town
2015-2025
Groote Schuur Hospital
2008-2011
Statistical Service
2007
Université de Yaoundé I
2006
Whipps Cross University Hospital
2006
Tuberculous pericarditis is associated with high morbidity and mortality even if antituberculosis therapy administered. We evaluated the effects of adjunctive glucocorticoid Mycobacterium indicus pranii immunotherapy in patients tuberculous pericarditis.Using a 2-by-2 factorial design, we randomly assigned 1400 adults definite or probable to either prednisolone placebo for 6 weeks M. placebo, administered five injections over course 3 months. Two thirds participants had concomitant human...
Journal Article Hairdressing and the prevalence of scalp disease in African adults Get access N.P. Khumalo, Khumalo Division Dermatology Correspondence: Khumalo. E‐mail: nonhlanhla.khumalo@uct.ac.za; n_khumalo@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar S. Jessop, Jessop F. Gumedze, Gumedze Department Statistical Sciences R. Ehrlich School Public Health Family Medicine, Groote Schuur Hospital University Cape Town, Observatory 7925, South Africa...
The incidence of tuberculous pericarditis has increased in Africa as a result the human immunodeficiency virus (HIV) epidemic. However, effect HIV co-infection on clinical features and prognosis is not well characterised. We have used baseline data Investigation Management Pericarditis (IMPI Africa) registry to assess impact presentation, diagnostic evaluation, treatment patients with suspected sub-Saharan Africa.Consecutive adult 15 hospitals three countries were recruited commencement for...
Anecdotal reports suggest that certain disorders are common in African hair and may be associated with hairstyles.A cross-sectional study of 1042 schoolchildren was performed to test this hypothesis.A questionnaire administered scalp examinations performed, after ethics approval.Participants included 45% boys 55% girls. The majority boys, 72.8%, kept natural frequent haircuts (within 4 weeks). prevalence acne (folliculitis) keloidalis nuchae (AKN) 0.67% the whole group highest (4.7%) final...
Aims There is controversy regarding the inclusion of patients with hypertension among cases peripartum cardiomyopathy (PPCM), as practice has contributed significantly to discrepancy in reported characteristics PPCM. We sought determine whether hypertensive heart failure pregnancy (HHFP) (i.e., cardiac associated any form hypertension) and PPCM have similar or different clinical features outcome. Methods Results compared time onset symptoms, profile (including electrocardiographic [ECG]...
BackgroundTuberculous pericarditis is considered to be a paucibacillary process; the large pericardial fluid accumulation attributed an inflammatory response tuberculoproteins. Mortality rates are high. We investigated role of clinical and microbial factors predictive tuberculous mortality using artificial intelligence algorithm termed classification regression tree (CART) analysis.MethodsPatients were prospectively enrolled followed in Investigation Management Pericarditis (IMPI) registry....
Meta-analysis typically involves combining the estimates from independent studies in order to estimate a parameter of interest across population studies. However, outliers often occur even under random effects model. The presence such could substantially alter conclusions meta-analysis. This paper proposes methodology for identifying and, if desired, downweighting that do not appear representative they are thought represent An outlier is taken as an observation (study result) with inflated...
The system of academic promotion provides a mechanism for the achievements staff to be recognised. However, it can that creates or reflects inequalities, with certain groups rising top more readily than others. In many universities, especially in global North, white men are preponderant senior ranks. This leads concerns about sexism and racism operating within processes promotion. There is sensitivity hierarchies should demographically representative. this study, we examine data on eleven...
Understanding the elastic material behavior of myocardium during diastolic phase is critical for evaluating cardiac function and improving treatments abnormalities. This study introduces a novel multi-objective optimization framework that incorporates both strain volume measurements to enhance accuracy myocardial property assessments in Rheumatic Heart Disease (RHD) patients healthy controls. By employing global instead segmented strains from sixteen AHA regions, we achieve robust alignment...
Pericardial constriction is a serious complication of tuberculous pericardial effusion that occurs in up to quarter patients despite anti-tuberculosis chemotherapy. The impact human immunodeficiency virus (HIV) infection on the incidence constrictive pericarditis following unknown.We conducted prospective observational study determine association between HIV and among 185 (median age 33 years) with suspected effusion. These were recruited consecutively March October 2004 commencement...
Abstract Background Folliculitis keloidalis nuchae (FKN), characterized by nucheal pimples and keloids, has a predilection for curly African hair. The disease is 10 times more common in males than females. aim of this study was to investigate determinants FKN males. Methods Factors associated with the presence were investigated from two cross‐sectional studies involving 1042 children 874 adults, respectively. All participants had given informed consent. A clinical diagnosis made only if...
Cardiomyopathies are an important cause of heart failure in Africa yet there limited data on etiology and clinical phenotypes. The IMHOTEP (African Cardiomyopathy Myocarditis Registry Program) was designed to systematically collect individuals diagnosed with cardiomyopathy living Africa. In this multicenter pilot study, patients (age ≥13 years) were eligible for inclusion if they had a diagnosis or myocarditis. Cases grouped analyzed according phenotype; dilated (DCM) including myocarditis...
To verify whether a deficiency in the cardiac sarcoplasmic reticulum pump SERCA2a causes dysfunction humans.Cardiac performance was measured serendipitous human model of primary deficiency, Darier's disease, an autosomal dominant skin disorder caused by mutations inactivating one copy ATP2A2 gene, which encodes SERCA2a.Systolic and diastolic function contractility were assessed echocardiography at rest during exercise patients with disease known mutations. Fourteen compared 14 normal...
Rheumatoid arthritis (RA) is a multisystem, autoimmune disorder and confers one of the strongest risks for cardiovascular disease (CVD) morbidity mortality.To assess myocardial function vascular stiffness in RA patients with without risk factors (CVRFs) using magnetic resonance (CMR).Twenty-three no CVRFs (17 female, mean age 52 ± 13 years), 46 (32 53 12), 50 normal controls 11 (7 55 7 underwent CMR at 1.5 Tesla, including evaluation left ventricular (LV) ejection fraction, strain,...
The benefit of a given treatment can be evaluated via randomized clinical trial design. However, protocol deviations may severely compromise effect since such often lead to missing values. assumption that methods analysis account for the data cannot justified and hence based on plausible assumptions should used. An alternative simple imputation requires unverifiable about data. Therefore sensitivity performed investigate robustness statistical inferences In this paper, we tuberculosis...
<h3>Objective</h3> The prevalence, predictors and outcome of myopericarditis in patients with tuberculous (TB) pericarditis are unknown. <h3>Methods</h3> Eighty-one (mean age±SD, 36.1±13.3 years; 54 (66.7%) men; 58 (71.6%) HIV seropositive) TB were recruited between January 2006 September 2008. Myopericarditis was defined as echocardiographic LV systolic dysfunction (immediately after pericardiocentesis), elevated peripheral blood troponin T (>0.03 ng/mL), or creatine kinase (CK >174...