A5028820716- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Insect Pest Control Strategies
- Viral Infections and Vectors
- Insect and Pesticide Research
- Vector-borne infectious diseases
- Insect behavior and control techniques
- Diptera species taxonomy and behavior
- Parasites and Host Interactions
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Forensic Entomology and Diptera Studies
- Vector-Borne Animal Diseases
- Syphilis Diagnosis and Treatment
- Leptospirosis research and findings
- Public Health and Social Inequalities
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Eating Disorders and Behaviors
- Mosquito-borne diseases and control
- Synthesis and Biological Evaluation
- Parasite Biology and Host Interactions
- Insect symbiosis and bacterial influences
- Venomous Animal Envenomation and Studies
- Insect-Plant Interactions and Control
- Dermatological diseases and infestations
Universidad de Granada
2016-2025
Universidad de Ciencias Médicas de la Habana
2025
Ministerio de Salud Pública
2024
Universidad San Gregorio de Portoviejo
2024
Hospital Universitario 12 De Octubre
2011
Hospital Universitario de Valme
2004
Universidad de Extremadura
1988-1990
Universidad de Málaga
1990
Centro de Implantología Cirugía Oral y Maxilofacial
1986-1988
Hospital Central Militar
1952
Abstract To examine prevalence changes and risk factors for canine leishmaniasis, we conducted a cross-sectional seroprevalence study survey during April–June 2006. Seroprevalence had increased at the meso-Mediterranean bioclimatic level over 22 years. Risk was highest dogs that were older, large, lived outside, level.
SUMMARY The domestic dog is the reservoir host of Leishmania infantum , causative agent zoonotic visceral leishmaniasis endemic in Mediterranean Europe. Targeted control requires predictive risk maps canine (CanL), which are now explored. We databased 2187 published and unpublished surveys CanL southern A total 947 western met inclusion criteria for analysis, including serological identification infection (504, 369 dogs tested 1971–2006). Seroprevalence was 23 2% overall (median 10%)....
Abstract. The bloodsucking adult females of Phlebotomus perniciosus Newstead and P. longicuspis Nitzulescu (Diptera: Psychodidae) are important vectors the protozoan Leishmania infantum Nicolle (Kinetoplastida: Trypanosomatidae) in western Mediterranean countries. species status two phlebotomine sandflies was assessed, along with epidemiological implications. Individual from three Moroccan Rif populations were characterized morphologically, isoenzymatically (by isoelectrofocusing alleles at...
Abstract Toscana virus (TOSV, Phlebovirus, family Bunyaviridae) infection is one of the most prevalent arboviruses in Spain. Within objectives a multidisciplinary network, study on epidemiology TOSV was conducted Granada, southern The overall seroprevalence rate 24.9%, significantly increasing with age. detected 3 103 sandfly pools by viral culture or reverse transcription–polymerase chain reaction from region L gene. Nucleotide sequence homology 99%–100% vectors and patients 80%–81%...
The aim of the present study was to assess in vitro and vivo activity (−)-α-bisabolol (1) against etiological agents visceral leishmaniasis. Bone-marrow-derived macrophages were infected with Leishmania infantum or L. donovani promastigotes incubated at different concentrations. Pentamidine isethionate meglumine antimoniate used as reference drugs. Inhibitory concentration 50% (IC50) cytotoxic (CC50) calculated. Balb/c mice intraperitoneally stationary-phase promastigotes. They treated doses...
Individuals with frequent exposures to agents spread through the parenteral route show a high prevalence of Leishmania seropositivity in Spain. However, frequency positive polymerase chain reaction (PCR) results for blood this setting remains unknown. In study, L. infantum kinetoplast DNA (kDNA) was found from 23 (24%) 95 asymptomatic individuals serum antibody titer ≥ 1:20 and none 44 seronegative individuals. The greater titer, proportion PCR-positive samples, but 16 (20%) 81 titers ≤ 1:40...
SUMMARY The aim of this study was to construct risk maps for the presence dominant Leishmania infantum vector, P. perniciosus, and check its usefulness (a) predict canine leishmaniasis (b) define effective control measures. We obtained data presence/absence perniciosus at 167 sampling sites in southern Spain, from which we also took a series ecological climate-related data. probability estimated as function these environmental variables generated spatial maps. Altitude, land use drainage...
There is limited information regarding the role of wild mammals in transmission dynamics Leishmania infantum. A potential human leishmaniasis hot spot was detected southern Spain that could not be explained solely by canine prevalence. The aim this work to analyse involvement rabbits as main factor affecting Mediterranean spot. survey rabbits, dogs and sand flies conducted cases environment. nearby region without clinical used reference control. 51 shot hunters were analysed molecular...
On the basis of partial amplification a cloned fragment kDNA Leishmania infantum which is specific for this species, we developed PCR–ELISA technique avoids problems associated with classical diagnostic techniques. This was tested on 33 L. strains from 19 different zymodemes, were recognized equally. It also used human and canine clinical samples. has higher sensitivity than other techniques (IFAT, parasite cultures, optical microscopy stained samples) permits detection minimum 0.1...
The aim of this study was to explore Leishmania infantum epidemiology through a One Health approach that promotes better estimation leishmaniasis burden and deeper understanding the spatial distribution key actors parasite life cycle (vectors, reservoirs humans). We conducted 14-year mixed retrospective prospective cases in an endemic area southern Spain (Granada province), estimate human incidence its association with vector presence, cryptic rates canine prevalence. found annual linear...
Abstract Background Vector-borne diseases such as leishmaniasis exert a huge burden of morbidity and mortality that are mainly controlled through vector control. The increasing threat insecticide-resistant vectors entails incorporating more control interventions to eliminate these diseases. Introduction Wolbachia into wild populations has been suggested potential measure would require extensive regional knowledge. aim this work is estimate the prevalence infection monitor circulating strains...
Leishmaniasis by Leishmania infantum has a zoonotic transmission cycle involving an increasing number of mammalian hosts, forming cooperative network. The sand fly feeding on livestock is evidenced, but clinical confirmation regarding their infection limited. We aimed to evaluate seroprevalence in assess its impact leishmaniasis epidemiology endemic area located the Mediterranean region. A cross-sectional serological study screened exposure L. and risk factors Southern Spain. total 864 serum...
Over a period of more than 10 years we have isolated and classified 161 Leishmania strains from cases human visceral, cutaneous mucosal leishmaniasis in immunocompetent subjects, visceral immunocompromised individuals with HIV, dogs (visceral cutaneous), Rattus rattus sandflies. The were all L. infantum, the only species endemic Spain, corresponded to 20 different zymodemes. We describe life cycle these zymodemes for which, most cases, partially know hosts involved. also discuss possible...
ABSTRACT Visceral leishmaniasis (VL) caused by Leishmania infantum is a common disease in human immunodeficiency virus (HIV)-infected people the Mediterranean basin. However, most such cases are asymptomatic, and little information about prevalence of these infections HIV-infected individuals available. The aim this study was to assess subclinical infection relationship between several markers noninvasive methods asymptomatic patients from Southern Spain. Ninety-two patients, who were...