A5040812609- Neonatal Respiratory Health Research
- Sepsis Diagnosis and Treatment
- Mesenchymal stem cell research
- Respiratory Support and Mechanisms
- Immune Response and Inflammation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Advanced Glycation End Products research
- Pancreatitis Pathology and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemodynamic Monitoring and Therapy
Ulsan College
2015-2019
University of Ulsan
2014-2019
Asan Medical Center
2015-2019
Acute respiratory distress syndrome (ARDS) is a type of acute failure in critically ill patients. Recently, several treatment modalities have been proposed for ARDS, but it still has high mortality rate. In general, the role mesenchymal stem cells (MSCs) controlling inflammatory responses studied various immune-associated diseases humans and animals. However, only few studies reported adipose-derived (ASCs), which are easier to isolate, currently emerging as an attractive option ARDS....
High mobility group box 1 (HMGB1) plays a central role in the pathogenesis of sepsis and multiple organ dysfunction syndromes. We investigated associations single nucleotide polymorphism (SNP; rs1045411) HMGB1 with various clinical parameters, severity, prognosis patients sepsis, severe or septic shock.We enrolled 212 adult followed for 28 days. All were genotyped rs1045411, serum levels several cytokines measured.The proportions according to genotype GG (71.2%), GA (26.4%), AA (2.4%). Among...
Background: Mesenchymal stem cells (MSCs) attenuate injury in various lung models through paracrine effects.We hypothesized that intratracheal transplantation of allogenic MSCs could lipopolysaccharide (LPS)-induced acute (ALI) mice, mediated by anti-inflammatory responses.Methods: Six-week-old male mice were randomized to either the control or ALI group.ALI was induced LPS instillation.Four hours after instillation, phosphate-buffered saline randomly intratracheally administered.Neutrophil...
Abstract Disruption of the endothelial glycocalyx has a prominent role in pathophysiology sepsis. Developmental locus-1 (Del-1) is an endothelial-derived anti-inflammatory factor. We hypothesized that degradation during sepsis may increase serum Del-1. A mouse model was created using cecal ligation and puncture. In septic mice, nearly completely degraded, with less formation Del-1 endothelium extracellular matrix than control mice. Serum levels were significantly increased mice increasing...