A5067354645- Gout, Hyperuricemia, Uric Acid
- Alcohol Consumption and Health Effects
- Chronic Kidney Disease and Diabetes
- Liver Disease Diagnosis and Treatment
- Advanced Glycation End Products research
- Folate and B Vitamins Research
- Digestive system and related health
- Nutritional Studies and Diet
- Dialysis and Renal Disease Management
- Sirtuins and Resveratrol in Medicine
- Colorectal Cancer Screening and Detection
- Retinal Diseases and Treatments
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Acute Kidney Injury Research
- Muscle and Compartmental Disorders
- Pancreatic function and diabetes
- Autophagy in Disease and Therapy
- Cardiovascular Function and Risk Factors
Tianjin Medical University
2018-2022
Wuhan Third Hospital
2022
Tongren Hospital
2022
Tianjin Infectious Diseases Hospital
2018
Kobe University
2000
Aim: Vildagliptin (vild) improves diastolic dysfunction and is associated with a lower relative risk of major adverse cardiovascular events in younger patients. The present study aimed to evaluate whether vild prevents the development diabetic cardiomyopathy type 2 mice identify its underlying mechanisms. Methods: Type mouse model was generated using wild-type (WT) (C57BL/6J) miR-21 knockout by treatment HFD/STZ. Cardiomyocyte-specific overexpression achieved adeno-associated virus 9....
Background: The aim of this study was to evaluate the diagnostic value six urinary biomarkers for prediction diabetic kidney disease (DKD). Methods: cross-sectional recruited 1053 hospitalized patients with type 2 diabetes mellitus (T2DM), who were categorized into (DM) normoalbuminuria (NA) group ( n = 753) and DKD 300) according 24-h albumin excretion rate (24-h UAE). Data on levels studied [transferrin (TF), immunoglobulin G (IgG), retinol-binding protein (RBP), β-galactosidase (GAL),...
Abstract Aims/Introduction Hyperuricemia ( HUA ) occurs because of decreased excretion uric acid, increased synthesis acid or a combination both mechanisms. The proportions these three types in type 2 diabetes patients are not known. In the mean time, we assume that different might manifest with renal damage, even normal filtration function. Materials and Methods We included 435 inpatients at Metabolic Disease Hospital Tianjin Medical University from 2015 to 2016. Based on clearance 90 were...
The relationship between urinary excretion rate of glucose (UEGL) and uric acid (UA) metabolism in adults with type 2 diabetes (T2D) remains unclear to date. This study aimed investigate the relationships UEGL serum UA (SUA), (UEUA), renal clearance (CLUA) T2D. We hypothesised that high increases excretion, which turn leads lower SUA. was a cross-sectional 635 inpatients T2D recruited 2018 2019. UEUA, CLUA, hyperuricaemia were assessed using analysis covariance multivariate regression...
Increasing evidence indicates that impaired glucose tolerance (IGT) is independently associated with chronic kidney disease, but the characteristics and underlying mechanisms remain largely unknown.Here, cross-sectional study was performed to of IGT-induced renal injury (IGT-RI). Furthermore, urine microRNA profile evaluated microRNAs involved in tubular were determined by in-vitro experiments.It found 12.1% IGT patients had microalbuminuria, which we termed "IGT-RI." Overall, 100% IGT-RI...
A safe and effective approach is needed to prevent reduce the incidence of diabetes worldwide. The hypoglycemic efficacy salicylic acid (salsalate, SAL), which has anti-inflammatory properties, been empirically demonstrated in studies conducted at Joslin Diabetes Center elsewhere. Here, we investigated potential role SAL preventing onset Zucker diabetic fatty (ZDF) rats attempted elucidate its underlying mechanisms. ZDF lean (ZL) were administered a high-fat diet with or without intervention...
Patients with diabetic ketosis often exhibit albuminuria. We previously found that acute hyperglycaemia can cause nephrotoxic injury. Here, we explored whether an excessive ketone body level causes kidney injury and the potential underlying mechanism. Fifty-six type 2 diabetes without (NDK group), 81 (DK 38 healthy controls (NC group) were enrolled. Clinical data collected before after controlling ketosis. Beta-hydroxybutyric acid (BOHB), AKT activator, inhibitor, or plasmids encoding DAB2...