A5085239711- Gestational Diabetes Research and Management
- Obesity, Physical Activity, Diet
- Bariatric Surgery and Outcomes
- Pregnancy and preeclampsia studies
- COVID-19 Clinical Research Studies
- Breastfeeding Practices and Influences
- Birth, Development, and Health
- Maternal Mental Health During Pregnancy and Postpartum
- Diet and metabolism studies
- Long-Term Effects of COVID-19
- Maternal and fetal healthcare
- Mobile Health and mHealth Applications
- Diabetes Management and Education
- SARS-CoV-2 and COVID-19 Research
- Eating Disorders and Behaviors
- Pharmacology and Obesity Treatment
- Nutritional Studies and Diet
- COVID-19 and Mental Health
- Obesity and Health Practices
- Health Systems, Economic Evaluations, Quality of Life
- Maternal and Perinatal Health Interventions
- Health and Wellbeing Research
- Health and Well-being Studies
- Diabetes Management and Research
- Prenatal Substance Exposure Effects
University of Colorado Denver
2015-2025
University of Colorado Anschutz Medical Campus
2016-2025
Brigham and Women's Hospital
2012-2023
Denver Health Medical Center
2023
Health and Hospital Corporation
2023
Colorado School of Public Health
2016-2021
Beth Israel Deaconess Medical Center
2012-2019
Old Dominion University
2016
National Institutes of Health
2014
National Center for Complementary and Integrative Health
2014
Early treatment to prevent severe coronavirus disease 2019 (Covid-19) is an important component of the comprehensive response acute respiratory syndrome 2 (SARS-CoV-2) pandemic.
Women who develop gestational diabetes mellitus (GDM) have an increased risk for the development of type 2 diabetes. Despite this "window opportunity," few intervention studies targeted postpartum women with a history GDM. We sought perspectives GDM to identify a) barriers and facilitators healthy lifestyle changes postpartum, b) specific approaches that would facilitate participation in program. used mixed methods gather data from prior GDM, including focus groups informant interviews....
In Brief OBJECTIVE: To test the feasibility and effectiveness of a Web-based lifestyle intervention based on Diabetes Prevention Program modified for women with recent gestational diabetes mellitus to reduce postpartum weight retention. METHODS: We randomly allocated 75 either program (Balance after Baby) delivered over first year or control group. Primary outcomes were change in body at 12 months from 1) measured weight; 2) self-reported prepregnancy weight. RESULTS: There no significant...
Abstract Background Metformin has antiviral activity against RNA viruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The mechanism appears to be suppression of protein translation via targeting the host mechanistic target rapamycin pathway. In COVID-OUT randomized trial for outpatient disease 2019 (COVID-19), metformin reduced odds hospitalizations/death through 28 days by 58%, emergency department visits/hospitalizations/death 14 42%, and long COVID 10 months...
Abstract Observational studies suggest outpatient metformin use is associated with reduced mortality from coronavirus disease‐2019 (COVID‐19). Metformin known to decrease interleukin‐6 and tumor‐necrosis factor‐α, which appear contribute morbidity in COVID‐19. We sought understand whether was odds of severe COVID‐19 disease a large US healthcare data set. Retrospective cohort analysis electronic health record (EHR) that pooled across multiple EHR systems 12 hospitals 60 primary care clinics...
Long Covid is an emerging chronic illness potentially affecting millions, sometimes preventing the ability to work or participate in normal daily activities. COVID-OUT was investigator-initiated, multi-site, phase 3, randomized, quadruple-blinded placebo-controlled clinical trial (NCT04510194). The design simultaneously assessed three oral medications (metformin, ivermectin, fluvoxamine) using two by parallel treatment factorial assignment efficiently share placebo controls and outcomes for...
Prevalence of metabolic syndrome (MetS) increased from one-quarter to one-third the U.S. adult population over 8 years and is spreading young adults Asian Hispanic Americans. Diagnosed when >3 out 5 cardiometabolic risk factors are present, there widespread agreement that its fundamental roots in a lifestyle characterized by poor dietary quality physical inactivity. Past trials for MetS produce benefits have limited sustainability, suggesting need new treatment approaches.
A history of preeclampsia is a risk factor for the future development hypertension and cardiovascular disease (CVD). The objective this study was to assess, in women with prior preeclampsia, level knowledge regarding link between CVD, motivators barriers lifestyle change interest modification program decrease CVD following pregnancy complicated by preeclampsia.Twenty participated 5 phone-based focus groups. Focus groups were recorded, transcribed, analyzed. Qualitative content analysis used...
Data conflict on whether vaccination decreases severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load. The objective of this analysis was to compare baseline load and symptoms between vaccinated unvaccinated adults enrolled in a randomized trial outpatient disease 2019 (COVID-19) treatment.
Preeclampsia predicts future cardiovascular disease (CVD) yet few programs exist for post-preeclampsia care.
Current antiviral treatment options for SARS-CoV-2 infections are not available globally, cannot be used with many medications, and limited to virus-specific targets.
Background Postpartum women with overweight/obesity and a history of adverse pregnancy outcomes are at elevated risk for cardiometabolic disease. weight loss lifestyle changes can decrease these risks, yet traditional face-to-face interventions often fail. We adapted the Diabetes Prevention Program into theory-based mobile health (mHealth) program called Fit After Baby (FAB) tested FAB in randomized controlled trial. Methods The provided 12 weeks daily evidence-based content, facilitated...
Abstract Objective: Overweight and obesity are associated with increased high‐sensitivity C‐reactive protein (hsCRP) levels. The purpose of this study was to determine if weight loss diets differing in fat, protein, or carbohydrate composition differentially reduce hsCRP. Design Methods: POUNDS (preventing overweight using novel dietary strategies) LOST a 2‐year trial obese adults randomly allocated one four targeted percentages energy derived from carbohydrates (20, 15, 65%; 20, 25, 55%;...
Objectives: In this study, we describe the relationship between metabolic syndrome (MetS) components and tobacco use other behavioral socio-economic characteristics. Methods: We collected demographic, anthropometric, bioclinical data on 961 individuals at risk of MetS. categorized frequency product substances (alcohol cannabis) as never, occasional, regular. used regression models to assess substance with MetS Results: Tobacco differed significantly by age, gender, race, education,...
The prevalence of metabolic syndrome (MetS) continues to increase. severity MetS can be defined by the number components or, more recently, a continuous score (MetSSS). However, studies that examine lifestyle factors predictive severity, in general, are lacking. This study aims compare behaviors (eg, physical activity and diet), health perceptions overall mental perceptions), psychosocial outcomes perceived stress social support) among people with varied evaluate associations MetSSS....
Obesity in pregnancy is the leading cause of maternal and fetal morbidity, gestational weight gain (GWG) one modifiable risk factor that improves outcomes. Most pregnant women more than 2009 Institute Medicine recommendations, particularly overweight obese women. GWG even less IOM guidelines may improve outcomes reduce large-for-gestational-age (LGA) infants, an independent for childhood obesity, without increasing small-for-gestational-age (SGA) infants. Unfortunately, despite fact over 50...