A5073274544- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- COVID-19 Clinical Research Studies
- Hemoglobinopathies and Related Disorders
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- COVID-19 and Mental Health
- Folate and B Vitamins Research
- Medical Malpractice and Liability Issues
- Blood Coagulation and Thrombosis Mechanisms
- Inflammatory Myopathies and Dermatomyositis
- Blood disorders and treatments
- Sarcoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- COVID-19 and healthcare impacts
- Biomedical Ethics and Regulation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood groups and transfusion
- Multiple Myeloma Research and Treatments
- Electroconvulsive Therapy Studies
- Cancer survivorship and care
- Hemostasis and retained surgical items
- Lymphatic System and Diseases
King Faisal Specialist Hospital & Research Centre
2014-2024
King Fahd Armed Forces Hospital
2020-2023
Harvard University
2021
Queen's University
2014-2017
University of Washington
2015
Seattle Cancer Care Alliance
2015
Seattle University
2015
Capital Health
2014
Acquired factor V inhibitor is a rare hemostatic disorder that presents with hemorrhagic manifestations in the vast majority of patients. Factor may develop through variety mechanisms involving development alloantibodies or autoantibodies specific to V. Autoantibodies, particular, have been reported number conditions. In this report, we describe case acquired patient mantle cell lymphoma who presented hematuria. Seven weeks after diagnosis and successful management, developed deep vein...
Chronic myelogenous leukemia is often treated using tyrosine kinase inhibitors such as dasatinib. Here we describe a rare case of inflammatory myopathy in patient with chronic the inhibitor dasatinib.A 69-year-old Caucasian man imatinib-resistant achieved complete molecular remission response to dasatinib therapy. However, from normal initial serum creatine level, he developed elevated levels and gradual-onset progressive muscle weakness after therapy was initiated. Our eventually diagnosed...
Immunocompromised patients who have a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection pose many clinical and public health challenges. We describe the case of hematopoietic stem cell transplantation patient with lymphoma had protracted illness requiring three consecutive hospital admissions. Whole genome sequencing confirmed two different SARS-CoV-2 clades. Clinical management issues unanswered questions arising from this are discussed.
Data on multisystem inflammatory syndrome in children (MIS-C) related to coronavirus disease-19 (COVID-19) is increasing the current COVID-19 pandemic. We present a 16 year old male who was hospitalized July 2020 under adult medical service due Kawasaki-like disease symptoms. Diagnosis of MIS-C established by clinical features, elevated markers, and positive SARS−COV 2 immunoglobulin G. encourage all clinicians especially practice medicine be familiar with signs symptoms avoid delayed...
BEAM conditioning regimen (carmustine [BCNU], etoposide, cytarabine, and melphalan) has been widely used for autologous stem cell transplantation in patients with relapsed or refractory lymphoma. However, BCNU-associated toxicities have prompted research to explore other options. This study aimed assess the feasibility of bendamustine as an alternative BCNU. We compared 71 who received either (Benda-EAM group) BCNU (BEAM conditioning. Considering previous reports increased cardiotoxicity,...
Although generally indolent, follicular lymphoma (FL) sometimes pursues a more aggressive course leading to early death. B-cell-specific Mo-MLV insertion site-1 (BMI1) is member of the polycomb group (PcG) proteins that confer stem cell properties through gene silencing. We used multi-channel immunofluorescence and automated image analysis quantify BMI1 selectively in nuclei FL-derived B-cells routine biopsy specimens. Applying this assay 109 pretreatment FL samples demonstrates significant...
Abstract Fludarabine busulfan anti‐thymocyte globulin is a common conditioning chemotherapy with reduced toxicity used for transplantation in sickle cell disease (SCD). The dose of this protocol variable across studies and centers. minimum that maintains long‐term donor chimerism not well established. We hypothesized lower, less‐toxic could be to maintain adequate long‐lasting chimeras, which might allow the inclusion older or comorbid patients disease. In our retrospective study 11...
Matched related and unrelated allogeneic nonmyeloablative hematopoietic transplantation (NMT) is increasingly being used in patients with hematologic malignancies. Conditioning regimens indications for NMT vary considerably from centre to centre. Our institution uses intravenous fludarabine cyclophosphamide, plus graft-versus-host disease (GVHD) prophylaxis tacrolimus mycophenolate mofetil. We retrospectively analyzed 89 consecutive who underwent (65 related, 24 unrelated) at our October...
Although malaria is no longer endemic in Canada, it remains an important imported disease, principally among immigrants and travellers. The role of exchange transfusion treatment, addition to standard anti-malarial controversial not well established. We report a case severe male traveller, complicated by multiorgan failure, septic shock, myositis, unusual Streptococcus pneumoniae bacteremia. Manual was used, artesunate-based therapy, the patient responded well. This shows that differential...
We quantified the potential impact of different social distancing and self-isolation scenarios on coronavirus disease 2019 (COVID-19) pandemic trajectory in Saudi Arabia compared modelling results to confirmed epidemic trajectory. Using susceptible, exposed, infected, quarantined self-isolated, requiring hospitalisation, recovered/immune individuals, fatalities model, we assessed a non-pharmacological interventions' subset. An unmitigated scenario (baseline), mitigation (25% reduction...
Rhabdomyolysis is a life-threatening syndrome resulting from striated muscular breakdown which needs early diagnosis and management. causes are various including, Heat-related injuries, Metabolic structural myopathies, drug induced, viral bacterial infection. Extrapulmonary manifestations of coronavirus disease 2019 (COVID-19) include pulmonary emboli, myocardial infarction, acute renal failure, cerebrovascular accident, liver injury, so on. In our case report we present 29-year-old female,...
Abstract Background: In patients with severe Glanzmann thrombasthenia (GT), a genetic platelet surface receptor disorder of glycoprotein IIb/IIIa (integrin αIIbβ3) that results in prolonged and chronic bleeding, hematopoietic stem cell transplantation (HSCT) is the only curative treatment option. Unfortunately, approximately 30% all undergoing HSCT die from this toxic procedure, owing to associated risk infection or graft-versus-host disease, adults at higher risk. Case presentation: Herein,...