Ultrasound has been applied therapeutically to accelerate connective tissue healing although there is little direct scientific evidence support its use. This investigation was conducted determine the effects of ultrasound on rate collagen synthesis and cell proliferation using cultured fibroblasts derived from Achilles tendons neonatal rats. Ultrasound(intensity = 0.4 W·cm-2; frequency 1 MHz) experimental cells growing as monolayers in culture flasks. had no effect by control over a period 9...

Tankyrase 1 is a poly(ADP-ribose) polymerase (PARP) that participates in broad range of cellular activities due to interaction with multiple binding partners. recognizes linear six-amino-acid degenerate motif and, hence, has hundreds potential target proteins. Binding partner proteins tankyrase usually results their poly(ADP-ribosyl)ation (PARsylation) and can lead ubiquitylation proteasomal degradation. However, it not known how PARP activity regulated. Here we identify GDP-mannose...

Yeast and human Clp1 proteins are homologous components of the mRNA 3′-cleavage-polyadenylation machinery. Recent studies highlighting an association (hClp1) with tRNA splicing endonuclease intrinsic RNA-specific 5′-OH polynucleotide kinase activity hClp1 have prompted speculation that might play a catalytic role in animal cells. Here, we show expression budding yeast can complement conditional lethal mutations essential RNA module or plant ligases. The is abolished by active site. In...

In this paper we study a substantial generalization of the model excited random walk introduced in [Electron. Commun. Probab. 8 (2003) 86-92] by Benjamini and Wilson. We consider discrete-time stochastic process $(X_n,n=0,1,2,...)$ taking values on ${\mathbb{Z}}^d$, $d\geq2$, described as follows: when particle visits site for first time, it has uniformly-positive drift given direction $\ell$; is at which was already visited before, zero drift. Assuming uniform ellipticity that jumps are...

The conditions (T) γ , ∊ (0,1), which were introduced by Sznitman in 2002, have had a significant impact on research random walk environment. Among others, these entail ballistic behavior as well an invariance principle. They require the stretched exponential decay of certain slab exit probabilities for under averaged measure and are asymptotic nature. main goal this paper is to show that all relevant dimensions (i.e., d ≥ 2), order establish it actually enough check corresponding condition...

Small Ras-like GTPases are conserved across eukaryotes and mediate many functions. Trypanosoma brucei encodes only three putative open reading frames belonging to Ras Rho subfamilies, all highly divergent from other taxa. We investigated the most gene product in T. brucei, TbRlp, evaluating essentiality, location impact of blocking GDP/GTP cycle. TbRlp is expressed both life stages, with a clear fitness contribution bloodstream forms vitro culture, without specific block cell cycle or...

Cyclic vomiting syndrome (CVS) is a chronic, recurrent disorder of unknown etiology characterized by episodes nausea and lasting hours or days separated symptom-free intervals weeks to months. Although several different therapeutic regimens have been suggested for CVS, there remains no standard, effective regimen. In many cases, management includes the use potent sedatives that induce prolonged durations sedation sleep. Dexmedetomidine an alpha(2) adrenergic agonist with increased...

We study a continuous time growth process on the d -dimensional hyper-cubic lattice \Bbb Z^d , which admits phenomenological interpretation as combustion reaction A+B\to 2A where A represent heat particles and B inert particles. This can be described an interacting particle system in following way: at 0 simple symmetric random walk of total jump rate one begins to move from origin lattice; then, soon any visits site previously unvisited by other walk, it creates new independent starting that...

In this work we study a natural transition mechanism describing the passage from quenched (almost sure) regime to an annealed (in average) one, for symmetric simple random walk on obstacles sites having identical and independent law. The was first proposed in context of sums exponents by Ben Arous, Bogachev Molchanov [Probab. Theory Related Fields 132 (2005) 579--612]. Let $p(x,t)$ be survival probability at time $t$ walk, starting site $x$, let $L(t)$ some increasing function time. We show...

We prove that a law of large numbers and central limit theorem hold for the excited random walk model in every dimension d ≥ 2.

RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyze methylation of the exocyclic N2 amine 7-methylguanosine. Here we performed a mutational analysis Tgs2, entailing an alanine scan 17 residues within minimal active domain. Alanine substitutions at Phe18, Thr40, Asp76, Asn103 Asp140 reduced methyltransferase specific activity to <3% wild-type thereby defining these essential. Alanines Pro142, Tyr148 Pro185 7–12% wild-type....

Surgical repair of rotator cuff (RC) tears is an effective treatment option. However, the prevalence recurrent ruptures high.Recurrent are a frequent complication surgical RC tears. Their incidence might be influenced by factors such as patient's age and size initial tear.Case series; Level evidence, 4.Data from 90 adult patients who underwent arthroscopic between 2014 2017 ultrasound examination 6 to 12 months after surgery were analyzed retrospectively. Massive repaired using double-row...

Nous démontrons un théorème de loi limite centrale presque sûr pour des marches aléatoires équilibrées non nécessairement aux plus proches voisins, dans milieu aléatoire ergodique. supposons que l'environnement satisfait conditions d'ergodicité et d'ellipicité appropriées. Notre preuve est basée sur principe du maximum opérateurs différences paraboliques.

We study the following microscopic model of infection or epidemic reaction: red and blue particles perform independent nearest-neighbor continuous-time symmetric random walks on integer lattice $\mathbb{Z}$ with jump rates $D_{R}$ for $D_{B}$ particles, interaction rule being that turn upon contact a particle. The initial condition consists i.i.d. Poisson particle numbers at each site, left origin red, while right are blue. interested in dynamics front, defined as rightmost position For case...

Consider a random walk in an i.i.d. uniformly elliptic environment dimensions larger than one. In 2002, Sznitman introduced for each $\gamma\in(0,1)$ the ballisticity condition $(T)_{\gamma}$ and $(T')$ defined as fulfillment of $\gamma\in(0,1)$. proved that implies ballistic law large numbers. Furthermore, he showed all $\gamma\in (0.5,1)$, is equivalent to $(T')$. Recently, Berger has three, (0,1)$, On other hand, Drewitz Ram\'{{\i}}rez have shown $d\ge2$ there constant...

Consider a random walk {Xn : n≥0} in an elliptic i.i.d. environment dimensions d≥2 and call P0 its averaged law starting from 0. Given direction $l\in\mathbb{S}^{d-1}$, Al={limn→∞ Xn⋅l=∞} is called the event that transient l. Recently Simenhaus proved following are equivalent: neighborhood of given direction; P0-a.s. there exists deterministic asymptotic any contained open half space defined by this direction. Here we prove P0(Al∪A−l)=1 ν such P0(Aν∪A−ν)=1 P0-a.s have...

6G promises a paradigm shift in which positioning and sensing are inherently integrated, enhancing not only the communication performance but also enabling location- context-aware services. Historically, have been viewed through lens of cost trade-offs, implying an escalated demand for resources, such as radio, physical, computational improved performance. However, goes beyond this traditional perspective to encompass set broader values, namely sustainability, inclusiveness, trustworthiness....