A5034793404- Antibiotic Resistance in Bacteria
- Vibrio bacteria research studies
- Salmonella and Campylobacter epidemiology
- Bacterial Identification and Susceptibility Testing
- Genomics and Phylogenetic Studies
- Viral gastroenteritis research and epidemiology
- Bacterial biofilms and quorum sensing
- Cancer Research and Treatments
- Escherichia coli research studies
- Plant Pathogenic Bacteria Studies
- Clostridium difficile and Clostridium perfringens research
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- Parasitic Infections and Diagnostics
- Zoonotic diseases and public health
- COVID-19 epidemiological studies
- Phytochemistry and Bioactivity Studies
- HIV/AIDS Research and Interventions
- Pneumocystis jirovecii pneumonia detection and treatment
- Ginger and Zingiberaceae research
- Antimicrobial Resistance in Staphylococcus
- Reproductive tract infections research
- Pancreatic and Hepatic Oncology Research
- Dermatological diseases and infestations
- Bacteriophages and microbial interactions
University College Hospital, Ibadan
1999-2024
University of Ibadan
1999-2022
<h2>Summary</h2><h3>Background</h3> Typhoid Fever remains a major cause of morbidity and mortality in low-income settings. The Severe Africa programme was designed to address regional gaps typhoid burden data identify populations eligible for interventions using novel conjugate vaccines. <h3>Methods</h3> A hybrid design, hospital-based prospective surveillance with population-based health-care utilisation surveys, implemented six countries sub-Saharan Africa. Patients presenting fever...
The antimicrobial activity of Spondias mombin, Croton zambesicus and Zygotritonia crocea sourced from herbalists through an ethnobotanical survey Egbado-South in Ogun State Nigeria is reported. extracts the leaf mombin stem bark exhibited wide spectrum antibacterial effects comparable to those ampicillin gentamycin. antifungal effect were tioconazole. There justification for use these little studied medicinal plants as antiinfective agents traditional medicine.
Abstract Background Klebsiella pneumoniae is a World Health Organization high-priority antibiotic-resistant pathogen. However, little known about lineages circulating in Nigeria. Methods We performed whole-genome sequencing (WGS) of 141 isolated between 2016 and 2018 from clinical specimens at 3 antimicrobial-resistance (AMR) sentinel surveillance tertiary hospitals southwestern conducted silico multilocus sequence typing; AMR gene, virulence plasmid, K O loci profiling; as well phylogenetic...
Acinetobacter baumannii bacteria are increasingly clinically relevant due to their propensity harbor genes conferring resistance multiple antimicrobials, as well ability persist and disseminate in hospital environments cause difficult-to-treat nosocomial infections. Little is known about the molecular epidemiology antimicrobial profiles of these organisms Nigeria, largely limited capacity for isolation, identification, susceptibility testing.
Background Salmonellosis causes significant morbidity and mortality in Africa. Information on lineages of invasive Salmonella circulating Nigeria is sparse. Methods enterica isolated from blood (n = 60) cerebrospinal fluid (CSF, n 3) between 2016 2020 five tertiary hospitals southwest were antimicrobial susceptibility-tested Illumina-sequenced. Genomes analysed using publicly-available bioinformatic tools. Results Isolates sequence types (STs) S . Typhi [ST1, 1 ST2, 43] non-typhoidal (iNTS)...
Whole-genome sequencing (WGS) is finding important applications in the surveillance of antimicrobial resistance (AMR), providing most granular data and broadening scope niches locations that can be surveilled. A common but often overlooked application WGS to replace or augment reference laboratory services for AMR surveillance. has supplanted traditional strain subtyping many comprehensive laboratories now gold standard rapidly ruling isolates into out suspected outbreak clusters. These...
Abstract Background The relative contribution of bacterial infections to febrile disease is poorly understood in many African countries due diagnostic limitations. This study screened pediatric and adult patients attending 4 healthcare facilities Ibadan, Nigeria, for bacteremia malaria parasitemia. Methods Febrile underwent clinical diagnosis, parasite testing, blood culture. Bacteria from positive cultures were isolated speciated using biochemical serological methods, Salmonella subtyping...
Acinetobacter baumannii are of major human health importance because they cause life-threatening nosocomial infections and often highly resistant to antimicrobials. Specific multidrug-resistant A. lineages implicated in hospital outbreaks globally. We retrospectively investigated a suspected outbreak carbapenem-resistant (CRAB) colonizing patients an intensive care unit (ICU) tertiary Southwest Nigeria where genomic surveillance has hitherto not been conducted.A prospective observational...
bloodstream infections are typically attributed to a limited number of lineages that carry virulence factors associated with invasiveness. In Nigeria, the identity circulating clones is largely unknown and surveillance their antimicrobial resistance has been limited. We verified whole-genome sequenced 68 2016-2018
Background Screening pregnant women for HIV and syphilis is recommended by WHO in order to reduce mother-to-child transmission. We evaluated the field performance, feasibility, acceptability of a dual rapid diagnostic test (RDT) antenatal clinic settings Nigeria. Methods findings Participants were recruited at 12 sites three states All consenting individuals tested according national testing algorithm, as well RDT, SD BIOLINE HIV/Syphilis Duo Test (Alere, USA), clinic. To determine...
Introduction Diarrhoea can be debilitating in young children. Few aetiological investigations Africans living with human immunodeficiency virus (HIV) have been performed since antiretrovirals became widely available. Methods Stool specimens from children diarrhoea HIV, and HIV-uninfected controls, recruited at two hospitals Ibadan, Nigeria, were screened for parasites occult blood, cultured bacteria. Following biochemical identification of least five colonies per specimen, diarrhoeagenic...
ABSTRACT Introduction Klebsiella pneumoniae is a World Health Organization high-priority antibiotic-resistant pathogen. However, little known about the population structure and evolution of circulating in Nigeria. Methods We performed whole genome sequencing (WGS) 141 isolated between 2016 2018 from clinical specimens at 3 antimicrobial-resistance (AMR) sentinel surveillance tertiary hospitals southwestern conducted silico multilocus sequence typing, AMR gene, virulence plasmid, K O loci...
ABSTRACT Background Salmonellosis causes significant morbidity and mortality in Africa. Despite being endemic Nigeria, information on circulating lineages of invasive Salmonella is sparse. Methods enterica isolated from blood (n=60) cerebrospinal fluid (CSF, n=3) between 2016 2020 five tertiary hospitals southwest Nigeria were antimicrobial susceptibility-tested Illumina-sequenced. Genomes analysed using publicly-available bioinformatic tools. Results Isolates sequence types (STs) S . Typhi...
Background: The Severe Typhoid in Africa program evaluated the burden of symptomatic typhoid infections and characterized clinical severity this disease six countries - Burkina Faso, Democratic Republic Congo, Ethiopia, Ghana, Madagascar, Nigeria. Methods: A hybrid, hospital-based prospective surveillance was implemented following a standard protocol. Patients presenting with fever (≥37·5°C axillary or ≥38·0°C tympanic) reporting for three consecutive days within previous seven were invited...
Volume 8, no. 3, e00098-23, 2023, https://doi.org/10.1128/msphere.00098-23. Page 12, Acknowledgments: The following statement should be added to the end of first paragraph. "We gratefully acknowledge clinical and diagnostic laboratory staff at institutions for contributing material this study: Babcock University Teaching Hospital, Ilishan-Remo, Ogun State; Clina-Lancet Laboratories, Victoria Island, Lagos EL-LAB Medical Diagnostics, Festac, Idi-Araba, Obafemi Awolowo Hospitals Complex,...
Enterobacter spp. are an important cause of healthcare-associated bloodstream infections uncommonly reported in Africa. This study used whole genome sequencing (WGS) to characterise from hospitals Nigeria s antimicrobial resistance (AMR) surveillance system. Blood-culture isolates six such tertiary-care recovered between 2014 and 2020 were re-identified susceptibility-tested using VITEK2. Illumina technology provided sequences for nomenclature, gene prediction, Single Nucleotide Polymorphism...
ABSTRACT Salmonella enterica s erovar Typhi is endemic in Nigeria where S. G allinarum rarely reported. Probable S . Gallinarum was blood-cultured from three Ibadan patients within 10-days leading to suspicion of an outbreak. All isolates were re-identified using VITEK-2, whole genome sequenced on Illumina and Oxford Nanopore platforms confirmed as genotype 3.1.1. Two the same household had no single nucleotide polymorphisms, suggesting a point-source, but third independent infection event....
Abstract Background Acinetobacter baumannii cause difficult-to-treat infections mostly among immunocompromised patients. Clinically relevant A. lineages and their carbapenem resistance mechanisms are sparsely described in Nigeria. Objective This study aimed to characterise the diversity genetic of strains isolated from hospitals southwestern Methods We sequenced genomes all isolates submitted Nigeria’s antimicrobial surveillance reference laboratory between 2016 – 2020 on an Illumina...
Background Treatment of the urinary tract infections (UTIs) is vast becoming worrisome because prominent antibiotic resistance among bacteria involve in infection. Species Ochrobacterum are also infection affecting and profusely to antibiotics. Methods Urine samples were collected from out-patients some hospitals isolated identified based on morphological biochemical characteristics. The most resistant isolate was selected for molecular identification by amplifying 16S rRNA gene. bacterial...
Many sub-Saharan African patients receive clinical care from extramurally-supported research and surveillance. Dur- ing the COVID-19 pandemic, pausing these activities reduces pa- tient care, surveillance, staff employment, increasing pandemic losses. In Oyo State, Nigeria, we paused a multi-country invasive salmonellosis surveillance initiative rural bac- teriology project.Working with partners raises health facility con- cerns about SARS-CoV-2 transmission risks incurs infection pre-...
Abstract Escherichia coli bloodstream infections are typically attributed to a limited number of lineages that carry virulence factors associated with invasion and, in recent years, invasive E. increasingly multiply antimicrobial resistant. In Nigeria, is common cause but the identity circulating clones largely unknown and surveillance their resistance has been limited. We verified whole genome-sequenced 68 isolates recovered between 2016 2018 at three sentinel sites southwestern Nigeria...