A5003310203- Cyclopropane Reaction Mechanisms
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Reactions
- Click Chemistry and Applications
- Polyoxometalates: Synthesis and Applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Analysis
- Catalytic Alkyne Reactions
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Characterization
- Zeolite Catalysis and Synthesis
- Synthesis and Biological Evaluation
- Metal-Organic Frameworks: Synthesis and Applications
- Electrochemical Analysis and Applications
- Synthesis and biological activity
- Organic and Inorganic Chemical Reactions
- Synthesis of heterocyclic compounds
- Protein Degradation and Inhibitors
- Analytical chemistry methods development
- Pharmaceutical and Antibiotic Environmental Impacts
St Petersburg University
2021-2024
Versar (United States)
2023
Nizhny Novgorod State Pedagogical University
2006-2008
Herein, we report a novel approach for the assembly of spirocyclic Δ
A three-component synthesis of 1,5-disubstituted 1,2,3-triazoles from α-acetyl-α-diazomethane sulfonamides, primary aliphatic amines, and aromatic aldehydes is presented. The can be accessed in two alternative variants, depending on the substitutions sulfonamide portion diazo reagent. In one variant, intermediate 1,2,3-triazoline-4-sulfonamides are isolated chromatographically then subjected to thermally promoted aromatization with elimination sulfur(IV) oxide amine. other both chemical...
A facile approach to novel medicinally relevant spiro heterocyclic scaffolds (namely furan-2(5 H )-ones, tetrahydrofurans and pyrans spiro-conjugated with the succinimide ring) has been developed. The protocol consists of Rh(II)-catalyzed insertion carbenes derived from diazoarylidene succinimides (DAS) into O–H bond propiolic/allenic acids or brominated alcohols, followed by base-promoted cyclization afford target spirocyclic compounds in good high yields.
Quinoline-based sulfonyl derivatives, and especially sulfonamides, are relevant promising structures for drug design. We have developed a new convenient protocol the synthesis of 3-sulfonyl-substituted quinolines (sulfonamides sulfones). The approach is based on Knoevenagel condensation/aza-Wittig reaction cascade involving o-azidobenzaldehydes ketosulfonamides or ketosulfones as key building blocks. appropriate both ketosulfonyl reagents α-sulfonyl-substituted alkyl acetates providing...
The previously described α-acetyl-α-diazomethanesulfonamide was employed in a three-component reaction with azide-containing benzaldehydes and propargylamines. Besides the initial formation of triazole core, proceeded further, uncatalyzed fashion at room temperature yielded, after intramolecular azide–alkyne click novel, structurally intriguing bistriazoles.
Abstract The X−H insertion reaction (X=heteroatom) of diazo compounds has emerged as an eminent and reliant approach for the construction C−X bonds. By merging with sequential ring‐closing transformations, diverse heterocyclic systems can be obtained in a step‐economical manner. In recent years, insertion/cyclization cascades one‐pot transformations attract more research attention, especially area asymmetric synthesis. Concentrating on assembly N,O,S‐heterocycles, this Concept elucidates...
The previously described α-acetyl-α-diazomethane sulfonamide was employed in a three-component reaction with azide-containing benzaldehydes and propargylamines. Besides the initial formation of triazole core, proceeded further, uncatalyzed fashion at room temperature yielded, after intramolecular azide-alkyne click novel, structurally intriguing bis-triazoles.
Quinoline based sulfonyl derivatives, and especially sulfonamides, are relevant promising structures for drug design. We have developed a new convenient protocol the synthesis of 3-sulfonyl substituted quinolines (sulfonamides sulfones). The approach is on Knoevenagel condensation/aza-Wittig reaction cascade involving o -azidobenzaldehydes ketosulfonamides or ketosulfones as key building blocks. appropriate both ketosulfonyl reagents α-sulfonyl alkyl acetates providing target quinoline...
A facile approach to novel medicinally relevant spiro heterocyclic scaffolds (namely furan-2(5 H )-ones, tetrahydrofurans and pyrans spiro-conjugated with the succinimide ring) has been developed. The protocol consists of Rh(II)-catalyzed insertion carbenes derived from diazo arylidene succinimides (DAS) into O-H bond propiolic/allenic acids or brominated alcohols, followed by base-promoted cyclization afford target spirocyclic compounds in good high yields.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access Abstract, please click on HTML or PDF.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access Abstract, please click on HTML or PDF.