About
Contact & Profiles
A5092160690
Research Areas
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Tulane University
2023
Acute hemorrhage commonly leads to coagulopathy and organ dysfunction or failure. Recent evidence suggests that damage the endothelial glycocalyx contributes these adverse outcomes. The physiological events mediating acute shedding are undefined, however. Here, we show succinate accumulation within cells drives degradation through a membrane reorganization-mediated mechanism. We investigated this mechanism in cultured cell hypoxia-reoxygenation model, rat model of hemorrhage, trauma patient...
10.1126/sciadv.adf6600
article
EN
cc-by-nc
Science Advances
2023-06-14
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