A5051563999- Animal Virus Infections Studies
- RNA regulation and disease
- Viral gastroenteritis research and epidemiology
- MicroRNA in disease regulation
- Viral Infections and Immunology Research
- interferon and immune responses
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Aquaculture Nutrition and Growth
- Analytical Chemistry and Chromatography
- Viral Infections and Outbreaks Research
- Cervical Cancer and HPV Research
- Fish Biology and Ecology Studies
- Fish biology, ecology, and behavior
- Advanced Chemical Sensor Technologies
- Molecular Biology Techniques and Applications
- Mosquito-borne diseases and control
Pontificia Universidad Javeriana
2023-2025
Universidad Nacional de Colombia
2022-2023
University of the Amazon
2018-2022
Extracellular vesicles (EVs) are small capsular bodies released by cells, mediating responses in intercellular communication. The role of EVs Aβ pathology spreading the Alzheimer's disease (AD) brain has been evidenced, although whether this occurs due to co-transportation peptides or contribution other factors, such as EV-associated transcripts, remains uncertain. In vitro studies miRNA cargo neuron-derived extracellular (NDEVs) show that hyperexpression alters transcriptomic profile;...
Neurodegenerative diseases (NDs) are characterized by a progressive deterioration of neuronal function, leading to motor and cognitive damage in patients. Astrocytes essential for maintaining brain homeostasis, their functional impairment is increasingly recognized as central the etiology various NDs. Such can be induced toxic insults with palmitic acid (PA), common fatty acid, that disrupts autophagy, increases reactive oxygen species, triggers inflammation. Although effects PA on...
Chronic intake of a high-fat diet increases saturated fatty acids in the brain causing progression neurodegenerative diseases. Palmitic acid is free abundant that at high concentrations may penetrate blood-brain barrier and stimulate production pro-inflammatory cytokines, leading to inflammation astrocytes. The use synthetic neurosteroid tibolone protection against toxicity emerging, but its transcriptional effects on palmitic acid-induced lipotoxicity remain unclear. Herein, we performed...
Similar to other RNA viruses, the emergence of Betacoronavirus relies on cross-species viral transmission, which requires careful health surveillance monitoring protein-coding information as well genome-wide analysis. Although evolutionary jump from natural reservoirs humans may be mainly traced-back by studying effect that hotspot mutations have proteins, it is largely unexplored if impacts might emerge structured genome Betacoronavirus. In this survey, and architecture were simultaneously...
In Amazonia, small-oriented family businesses or communities cultivate freshwater organisms as a source of income. Although effective management is fundamental for optimizing cultivated stocks, Amazonian aquaculture belittles the importance genetic diversity, relying primarily on phenotypical characteristics during breeders' selection. To provide "proof concept" built premise that implementing modern technologies crucial to fish stocks in rural farms, we conducted pilot study assessing...