A5037625819- T-cell and B-cell Immunology
- Rheumatoid Arthritis Research and Therapies
- CAR-T cell therapy research
- Immune Response and Inflammation
- SARS-CoV-2 detection and testing
- COVID-19 Pandemic Impacts
- Pregnancy and Medication Impact
- COVID-19 Impact on Reproduction
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Health and Lifestyle Studies
- Reproductive System and Pregnancy
- SARS-CoV-2 and COVID-19 Research
- Biosimilars and Bioanalytical Methods
Universidade Nova de Lisboa
2020-2023
University of Lisbon
2020-2021
Universidade Federal do Espírito Santo
2021
This study aimed to evaluate changes in dietary and lifestyle habits during the period of confinement due first wave COVID-19 pandemic Ibero-American countries. A cross-sectional investigation was conducted with 6,325 participants both genders (68% women), over 18 years age from five countries: Brazil ( N = 2,171), Argentina 1,111), Peru 1,174), Mexico 686), Spain 1,183). Data were collected year 2020, between April 01 June 30 July 13 September 26, other countries studied using a...
Seroprevalence studies are crucial both for estimating the prevalence of SARS-CoV-2 exposure and to provide a measure efficiency confinement measures. Portuguese universities were closed on March 16th 2020, when Portugal only registered 62 infection cases per million. We have validated ELISA assay stabilized full-length spike protein using 216 pre-pandemic 19 molecularly diagnosed positive individual's samples. At NOVA University Lisbon, presential work was partially resumed May 25th with...
Abstract CD4 + T cells mediate rheumatoid arthritis (RA) pathogenesis through both antibody-dependent and independent mechanisms. It remains unclear how synovial microenvironment impinges on pathogenic functions. Here, we identified a TLR4 follicular helper (Tfh) cell-like population present in the blood expanded fluid. possess two-pronged activity whereby direct engagement by endogenous ligands arthritic joint reprograms them from an IL-21 response, known to sponsor antibody production...
The intricate interplay between maternal immune response to SARS-CoV-2 and the transfer of protective factors fetus remains unclear. By analyzing mother-neonate dyads from second third trimester infections, our study shows that neutralizing antibodies (NAbs) are infrequently detected in cord blood. We uncovered this is due impaired IgG-NAb placental symptomatic infection predominance NAbs IgA IgM isotypes, which prevented crossing placenta. Crucially, balance antiviral transplacental...
Abstract CD4 + T cells mediate rheumatoid arthritis (RA) pathogenesis through both antibody-dependent and independent mechanisms. It remains unclear how synovial microenvironment impinges on pathogenic functions. Here, we identified a TLR4 follicular helper (Tfh) cell-like population present in the blood expanded fluid. Mechanistically, unveiled that homotypic T-T cell interactions non-cognate HLA-DR:TCR contacts regulate expression cells. possess two-pronged activity. Upon TCR ICOS...