A5048840363- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child and Adolescent Psychosocial and Emotional Development
- Suicide and Self-Harm Studies
- Healthcare professionals’ stress and burnout
- Mental Health Research Topics
- Neural dynamics and brain function
- Autism Spectrum Disorder Research
- Attention Deficit Hyperactivity Disorder
- Resilience and Mental Health
- COVID-19 and Mental Health
- Neuroscience and Music Perception
- Epigenetics and DNA Methylation
- Disaster Response and Management
- Adolescent and Pediatric Healthcare
- Bipolar Disorder and Treatment
- Heart Rate Variability and Autonomic Control
- Bioinformatics and Genomic Networks
- Neural and Behavioral Psychology Studies
- Folate and B Vitamins Research
- Child and Adolescent Health
- Schizophrenia research and treatment
- Genomics and Phylogenetic Studies
- Birth, Development, and Health
- Genetic Associations and Epidemiology
Shanghai Mental Health Center
2014-2025
Shanghai First People's Hospital
2016-2025
Shanghai Jiao Tong University
2014-2025
Jiaxing University
2016-2018
Scientific and clinical interest in attention-deficit hyperactivity disorder (ADHD) is increasing worldwide. This article presents data from a cross-national workshop survey related to questions of variability diagnostic and, particularly, treatment procedures.Representatives nine nations (Australia, Brazil, Canada, China, Germany, Israel, the Netherlands, Norway, United Kingdom), plus States, who attended 2010 on ADHD, responded that addressed procedures for ADHD; treated prevalence...
Background:We aimed to investigate the disruptions of functional connectivity amygdala-based networks in adolescents with untreated generalized anxiety disorder (GAD). Material andMethods:A total 26 first-episode GAD and 20 normal age-matched volunteers underwent resting-state T1 magnetic resonance imaging (fMRI). We analyzed correlation fMRI signal fluctuation between amygdala other brain regions. The variation its severity were investigated. Results:Decreased was found left dorsolateral...
Extensive evidence suggests that frontoparietal regions can dynamically update their pattern of functional connectivity, supporting cognitive control and adaptive implementation task demands. However, it is largely unknown whether this flexibly reconfiguration intrinsic occurs even in the absence overt tasks. Based on recent advances dynamics resting-state resonance imaging (fMRI), we propose a probabilistic framework which dynamic connectivity between each brain region others be represented...
Background Medical staff fighting the COVID-19 pandemic are experiencing stress from high occupational risk, panic in community and extreme workload. Maintaining psychological health of a medical team is essential for efficient functioning, but intervention models emergency teams rare. Aims To design systematic, full-coverage support scheme serving large-scale emergent situations, demonstrate its effectiveness real-world study Leishenshan Hospital during epidemic Wuhan, China. Methods The...
Background Facing the social panic and substantial shortage of medical resources during coronavirus disease 2019 (COVID-19) outbreak, providing psychological first-aid to inpatients is essential for their rehabilitation orderly operating systems. However, closed-ward environment extreme onsite mental health workers have limited use traditional face-to-face diagnosis interventions. Aim To develop a intervention model that can be applied widespread epidemic, such as COVID-19. Methods In team...
Using functional near-infrared spectroscopy technique, this study identified lower brain network efficiency in children with anxiety and/or depression compared to healthy controls, caregivers' evaluation of mood correlating efficiency.
Adolescents aged 12–18 with social anxiety disorder (SAD) manifest various emotional and behavioral problems, among which non-suicidal self-injury (NSSI) requires urgent attention. Coping mechanisms for psychological distress significantly impact their vulnerability to NSSI. Understanding the heterogeneity of coping styles adolescents SAD can help identify those at high risk However, existing research provides little insight into this matter. This study aims explore latent profiles in...
Abstract Background Social anxiety disorder (SAD) is a prevalent mental diagnosed in childhood and adolescence. Theories regarding brain development SAD suggest close link between neurodevelopmental dysfunction at the adolescent juncture SAD, but direct evidence rare. This study aims to examine structural abnormalities adolescents with SAD. Methods High-resolution T1-weighted images were obtained from 31 (15–17 years) 42 matching healthy controls (HC). We evaluated symptom severity Anxiety...
Non-suicidal self-injury (NSSI) behaviour is very common among adolescents. Its prevalence and behavioural characteristics may vary according to regional cultural differences. Investigation of NSSI locations diagnosis adolescents with are relatively lacking in China.The study objective was determine the features middle school students Shanghai.The participants were from grade 6 8 selected three junior schools Jing'an District. Consenting completed Ottawa Self-Injury Inventory NSSI. Those who...
Those injured in accidents commonly have strong emotional reactions to their situation. However, despite the large number of patients who are admitted general hospitals each year for orthopedic injuries due an accident, research focusing on psychological disorders these is lacking.To investigate presentation and factors related depression acute anxiety among inpatients being treated injury a Trauma Orthopedics Unit.323 with trauma were evaluated using Injury Severity Score (ISS), Hamilton...
Abstract Hyperactivity of limbic (e.g., amygdalar) responses to negative stimuli has been implicated in the pathophysiology generalized anxiety disorder (GAD). Evidence also suggested that even a simple cognitive task involving emotionally salient can modulate and prefrontal neural activation. However, whether modulation emotional stimulus processing is defective adolescents with GAD not yet investigated. In this study, 20 14 comparable healthy controls underwent event-related functional...
Background: Selective loss of dopaminergic neurons and diminished putamen gray matter volume (GMV) represents a central feature Parkinson's disease (PD). Recent studies have reported specific effects kinectin 1 gene (KTN1) variants on the GMV. Objective: To examine relationship KTN1 variants, mRNA expression in substantia nigra pars compacta (SNc), GMV, PD. Methods: We examined associations between PD total 1847 imputed single nucleotide polymorphisms (SNPs) one discovery sample [2,000...
Abstract Background The current study examined the change in local government staff’s emotional distress over 7 years after 2008 Wenchuan earthquake, and influence of earthquake exposure professional quality life (ProQOL) on distress. Methods This longitudinal assessed 250 participants at 1 year earthquake; 162 (64.8%) were followed up years. Emotional was with Self-Reporting Questionnaire (SRQ) both time points. We ProQOL, including compassion satisfaction, burnout, secondary traumatic...
Abstract Attention deficit hyperactivity disorder (ADHD) is associated with reduction of cortical and subcortical gray matter volumes (GMVs). The kinectin 1 gene ( KTN1 ) has recently been reported to significantly regulate GMVs ADHD risk. In this study, we aimed identify sex-specific, replicable risk alleles for explore their regulatory effects on mRNA expression GMVs. We examined a total 1020 SNPs in one discovery sample (ABCD cohort: 5573 males 5082 females) three independent replication...
Identifying pathogenetic variants and inferring their impact on protein–protein interactions sheds light functional consequences diseases. Limited by the availability of experimental data protein interaction, most existing methods focus building models to predict changes in binding affinity. Here, we introduced MIPPI, an end-to-end, interpretable transformer-based deep learning model that learns features directly from sequences leveraging interaction IMEx. MIPPI was specifically trained...