A5086428683- Advanced Fluorescence Microscopy Techniques
- Cell Image Analysis Techniques
- Congenital heart defects research
- Receptor Mechanisms and Signaling
- Tissue Engineering and Regenerative Medicine
- Colorectal Cancer Treatments and Studies
- Cardiomyopathy and Myosin Studies
- Cardiac and Coronary Surgery Techniques
- Advanced MRI Techniques and Applications
- Neuroscience and Neural Engineering
- Machine Learning in Materials Science
- Biofuel production and bioconversion
- Hydrology and Drought Analysis
- Bioenergy crop production and management
- Cardiac electrophysiology and arrhythmias
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Coronary Interventions and Diagnostics
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Cardiac Fibrosis and Remodeling
- Financial Risk and Volatility Modeling
- Bayesian Methods and Mixture Models
Peter MacCallum Cancer Centre
2021-2024
University of Central Florida
2019-2021
Australian National University
1999
We have developed and integrated several technologies including whole-organ imaging software development to support an initial precise 3D neuroanatomical mapping molecular phenotyping of the intracardiac nervous system (ICN). While qualitative gross anatomical descriptions anatomy ICN each been pursued, we here bring forth a comprehensive atlas entire rat at single-cell resolution. Our work precisely integrates data in digitally reconstructed whole heart with resolution micron scale. now...
We developed and analyzed a single cell scale anatomical map of the rat intrinsic cardiac nervous system (ICNS) across four male three female hearts. find ICNS has reliable structural organizational plan individuals that provide foundation for further analyses in function disease. The distribution was evaluated by 3D visualization data-driven clustering. pattern, distribution, clustering neurons all hearts is highly conserved, demonstrating coherent where distinct clusters are consistently...
ABSTRACT In this study, we developed, coordinated, and integrated several technologies including novel whole organ imaging, software development to support the very first precise 3D neuroanatomical mapping molecular phenotyping of intracardiac nervous system (ICN). While qualitative gross anatomical descriptions anatomy ICN have been presented, here bring forth comprehensive atlas at large scale entire in rat a single cell resolution. Our work for time provides model precisely integrate...
Summary We developed and analyzed a single cell scale anatomical map of the rat intrinsic cardiac nervous system (ICNS) across 4 male 3 female hearts. find ICNS has reliable structural organizational plan individuals that may provide foundation for further analyses in function disease. The distribution was evaluated by 3D visualization using data-driven clustering. pattern, clustering neurons all hearts is highly conserved, demonstrating coherent which distinct clusters are consistently...
A new distribution-free cumulative sum procedure is introduced. This aims to diagnose geographical–temporal clustering of events in parallel records over time neighbouring geographical areas a defined region or country. The applies the presence possible seasonality and yearly trend provided that those patterns are maintained all region. method applied specifically meningococcal disease.
The intrinsic cardiac nervous system (ICN) is involved in the autonomic control of heart and functions as an integrative center for local sensory extrinsic inputs. There has been increasing interest ICN neurons well their ablation a therapeutic intervention atrial fibrillation. goal present study to assess distribution between individuals with rat model using novel data acquisition pipeline combining Knife Edge Scanning Microscope (KESM) custom software developed by MBF (Tissue Mapper)...
This protocol describes the process of using Tissue Mapper software to map single neurons intrinsic cardiac nervous system, annotate or "trace" key anatomy on select histological sections an image volume, and visualize mapped traced in a 3D reconstructed heart.
In this study, we developed, coordinated, and integrated several technologies including novel whole organ imaging, software development to support the very first precise 3D neuroanatomical mapping molecular phenotyping of intracardiac nervous system (ICN). While qualitative gross anatomical descriptions anatomy ICN have been presented, here bring forth comprehensive atlas at large scale entire in rat a single cell resolution. Our work for time provides model precisely integrate anatomical,...
16 Background: The optimal adjuvant treatment regimen for stage III CRC patients aged ≥70 years remains unclear. Subgroup analyses of randomised trials support the use single agent fluoropyrimidines (FP) but no survival benefit has been observed addition oxaliplatin. This study assessed rates AC in elderly with CRC, analysed reasons why did not receive and compared disease free (DFS) between those who AC. Methods: Data was from ACCORD-CRC registry, which prospectively collects outcome data...