A5004206283- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Alcoholism and Thiamine Deficiency
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Memory and Neural Mechanisms
- Treatment of Major Depression
- Substance Abuse Treatment and Outcomes
- Sleep and Wakefulness Research
- Obsessive-Compulsive Spectrum Disorders
- Attention Deficit Hyperactivity Disorder
- Neuropeptides and Animal Physiology
- Pharmacological Receptor Mechanisms and Effects
- Epilepsy research and treatment
- Sleep and related disorders
- Neurological disorders and treatments
- Ethics in Clinical Research
- Advanced MRI Techniques and Applications
- Pharmacological Effects and Toxicity Studies
- Parkinson's Disease Mechanisms and Treatments
- Ion channel regulation and function
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Healthcare Decision-Making and Restraints
- Forensic Toxicology and Drug Analysis
Touro College
2017
Boston University
2005-2015
Bupa UK Foundation
2014
Boston Medical Center
2012
Behavioral Pharma (United States)
1989-2007
University of Leicester
2004-2006
VA Boston Healthcare System
2000-2005
National Center for PTSD
2003
National Center for Post Traumatic Stress Disorder
2003
National Institute on Drug Abuse
1997-2001
Increasing evidence suggests that deep brain stimulation (DBS), which is currently being used as a therapy for neurological diseases, may be effective in the treatment of psychiatric disorders well. Here, we examined influence DBS nucleus accumbens shell on cocaine priming-induced reinstatement drug seeking, an animal model relapse. Rats were allowed to self-administer (0.25 mg, i.v.) 2 h daily 21 d and then cocaine-seeking behavior was extinguished by replacing with saline. During phase,...
Increased aggressive behavior can occur in association with posttraumatic stress disorder (PTSD). This study tested the hypothesis that low-dose risperidone reduces aggression and other PTSD-related symptoms combat veterans. Subjects were male veterans PTSD who scored 20 or higher on cluster D (hyperarousal) of Patient Checklist for PTSD–Military Version (PCL-M). randomly assigned to either placebo treatment groups. Drugs administered over a 6-week period double-blind manner. received (0.5...
Background Subjects who enroll in multiple studies have been found to use deception at times overcome restrictive screening criteria. Deception undermines subject safety as well study integrity. Little is known about the extent which experienced research subjects and what type of information concealed, withheld, or distorted. Purpose This examined prevalence types used by enrolling studies. Methods Self-report deceptive behavior gain entry into clinical trials was measured among a sample 100...
The increased availability of highly palatable foods is a major contributing factor toward the development compulsive eating in obesity and disorders. It has been proposed that may develop as form self-medication to alleviate negative emotional state associated with withdrawal from foods. This study was aimed at determining whether chronic, intermittent access food responsible for emergence depressive-like behavior. For this purpose, group male Wistar rats provided regular chow diet 7 days...
Quetiapine is an atypical antipsychotic that has sedative effects. In this retrospective study, indices of alcohol use were compared for alcohol-dependent subjects who either (n = 30) or not 20) treated with quetiapine (25 to 200 mg nightly) disturbed sleep. Indices examined included total days abstinence, number hospitalizations detoxification, and first relapse over 1 year clinic treatment. Subjects male veterans. All had a diagnosis dependence, 90% in each group also diagnosed...
The anticonvulsant topiramate not only decreases ethanol consumption in alcohol dependence (AD) but also may produce several adverse events including cognitive impairment. Zonisamide is a structurally related that promising agent for the treatment of AD and have greater tolerability than topiramate. This study evaluated effects zonisamide (400 mg/d) on its neurotoxic subjects with AD. A double-blind placebo-controlled clinical trial was conducted using 2 comparator drugs, (300 levetiracetam...
The effects of the antidepressant venlafaxine (VEN-225 mg daily) and transdiagnostic cognitive behavioral treatment (CBT) alone in combination on alcohol intake subjects with co-morbid use disorders (AUDs) anxiety were compared. Drinking outcomes assessed for 81 treated 11 weeks one 4 conditions: 1) VEN–CBT, 2) VEN-Progressive Muscle Relaxation therapy (PMR), 3) Placebo (PLC)-CBT 4) a comparison group PLC-PMR. For who reported taking at least dose study medication, Time × Group interaction...
Background: Prior findings concerning the use of mirtazapine in treatment a variety substance disorders and its antagonistic actions at serotonin 5-HT2A receptor suggest that this drug may have efficacy cocaine dependence presence depressive disorder. Methods: Depressed cocaine-dependent subjects received either (target dose 45 mg daily) or placebo for 12 weeks. Urine concentrations benzoylecgonine self-report were used to assess consumption. Depression sleep quality evaluated using Hamilton...
In this investigation, the pharmacokinetic and pharmacodynamic properties were determined of multiple doses sublingual tablets containing either buprenorphine alone or naloxone. Subjects experienced opiate users who received escalating (4-24 mg) in combination with Peak concentration (Cmax) area under concentration-time curves (AUCs) increased for both naloxone doses. Significant differences found across range administered dose-adjusted Cmax tablet formulations AUCs buprenorphine-naloxone...
ABSTRACT Aims The two studies presented here were conducted to assess the efficacy of paroxetine, pentoxifylline, riluzole, venlafaxine and pramipexole as medications for treatment cocaine dependence. Design A multi‐arm, modified blinded, placebo‐controlled design was used. Setting at Boston VA Healthcare System University School Medicine Medication Development Research Unit (MDRU). Participants met criteria dependence during a 2‐week screening period. Intervention Following random...
Background: Activation of Kv7 potassium channels may decrease the reactivity mesolimbic dopaminergic neurons that are implicated in mediating reinforcing effects ethanol. Objectives: The objective this study was to determine whether administration channel opener retigabine would ethanol intake Long Evans rats. Methods: A limited access two-bottle choice model alcohol (10% solution) consumption used study. separate group animals tested evaluate actions on sucrose (5% drug might produce...
Objective: The purpose of this study is to examine the effects zonisamide on ethanol self-administration and subjective in risky drinkers using a human laboratory paradigm. Method: We conducted double-blind, placebo-controlled 100 mg urge drink (N = 10) (). Result: During second hour 2-hour session consumption was 50% lower group as compared placebo group. Urge also significantly under condition. Conclusion: These results indicate that single dose reduces quantity self-administered by during...
The aim of this open-label pilot study was to assess the efficacy and safety novel anticonvulsant agent, levetiracetam, for treatment alcohol dependence. A maximal dose 2000 mg administered daily 10 weeks dependent subjects (n = 20). Mean reported ethanol intake declined significantly from 5.3 1.7 standard drinks per day. Levetiracetam well tolerated by most subjects.
ABSTRACT Aims In the current study, nefazodone, an antidepressant with dual action on serotonin and norepinephrine reuptake as well 5‐HT 2A receptor antagonist effects, was studied in subjects cocaine dependence depressive symptoms, to determine its efficacy reducing use. Design An 8‐week, double blind, placebo‐controlled design used. Setting The study conducted at Medication Development Research Unit (MDRU) VA Boston Healthcare System Manhattan Department of Veterans Affairs (DVA) Medical...
Objectives: The objectives of this study are to assess the tolerability and efficacy anticonvulsant zonisamide in an open label trial treatment alcohol dependence. Methods: In trial, (400-mg daily) was administered alcohol-dependent subjects (ADS) (n = 16) over 13 weeks. mean daily consumption standard alcoholic drinks performance on a verbal fluency task, COWAT, measure attention visuomotor speed, DSMT were assessed, occurrence adverse events monitored weekly. Results: number consumed...