A5064193569- Pesticide Residue Analysis and Safety
- Radiopharmaceutical Chemistry and Applications
- Analytical Chemistry and Chromatography
- Radioactive element chemistry and processing
- Insect and Pesticide Research
- Analytical chemistry methods development
- Medical Imaging and Pathology Studies
- RNA modifications and cancer
- Medical Imaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Advanced Chemical Physics Studies
- Drilling and Well Engineering
- Antibiotics Pharmacokinetics and Efficacy
- Hydraulic Fracturing and Reservoir Analysis
- Environmental Toxicology and Ecotoxicology
- Pesticide and Herbicide Environmental Studies
- Formal Methods in Verification
- Electrochemical sensors and biosensors
- Pharmaceutical and Antibiotic Environmental Impacts
- Boron Compounds in Chemistry
- Monoclonal and Polyclonal Antibodies Research
- Lanthanide and Transition Metal Complexes
- Petri Nets in System Modeling
- Chinese history and philosophy
- Machine Learning in Bioinformatics
ZheJiang Academy of Agricultural Sciences
2016-2025
Ministry of Agriculture and Rural Affairs
2021-2025
Peking University
2011-2024
The First Hospital of Changsha
2011-2024
Beijing National Laboratory for Molecular Sciences
2007-2024
Changji University
2024
Yunnan University
2024
Shanghai Jiao Tong University
2023
Xinxiang Medical University
2020-2023
South China University of Technology
2023
The search for novel antimalarial drug targets is urgent due to the growing resistance of Plasmodium falciparum parasites available drugs. Proteases are attractive because their indispensable roles in parasite infection and development, especially processes host erythrocyte rupture/invasion hemoglobin degradation. However, date, only a small number proteases have been identified characterized species. Using an extensive sequence similarity search, we 92 putative P. genome. A set including...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA kinetic investigation of the lanthanide DOTA chelates. Stability and rates formation dissociation a macrocyclic gadolinium(III) polyaza polycarboxylic MRI contrast agentXiangyun Wang, Tianzhu Jin, Vinciane Comblin, Antonio Lopez-Mut, Emile Merciny, Jean F. DesreuxCite this: Inorg. Chem. 1992, 31, 6, 1095–1099Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March...
In this work, a novel low molecular weight zwitterionic copolymer for improving wellbore stability, which is expected to be an alternative the current shale inhibitors, was obtained by copolymerization of tris hydroxyethyl allyl ammonium bromide (THAAB), 2-acrylamido-2- methyl propane sulfonic acid (AMPS) and acrylamide (AM), initiated redox initiation system in aqueous solution. The copolymer, denoted as SX-1, characterized FT-IR, TGA-DSC, GPC. Results demonstrated that SX-1 approximately...
Based on the adsorption mechanism analysis of polyhydroxy organic compound a shale surface, novel amine hydration inhibitor N, N′, N′-tetrakis (2-hydroxyethyl) ethylenediamine (THEED) was synthesized via nucleophilic reaction by using diethanolamine and dibromoethane as raw materials. Its structure characterized Fourier transform infrared spectrometry (FTIR), Hydrogen Nuclear Magnetic Resonance (1H NMR) Liquid Chromatography Mass Spectrometry (LCMS). The inhibition performance THEED studied...
Elucidation of cell subpopulations at high resolution is a key and challenging goal single-cell ribonucleic acid (RNA) sequencing (scRNA-seq) data analysis. Although unsupervised clustering methods have been proposed for de novo identification populations, their performance robustness suffer from the variability, low capture efficiency dropout rates which are characteristic scRNA-seq experiments. Here, we present novel method Single-cell Clustering by Enhancing Network Affinity (SCENA),...
Penflufen fungicide is widely used as a racemate, which has potential ecological risks to aquatic organisms, while its enantioselective toxicity data limited. This study aimed differentiate the difference of penflufen enantiomers, and illuminate mechanism from insight enantiomer-protein specific binding. The semipreparative separation absolute configuration enantiomers were conducted. acute S-(+)-penflufen was 54 times higher than R-(-)-penflufen Danio rerio, coexistence could increase...
The golden apple snail Pomacea canaliculata is an invasive pest that causes extensive damage to agricultural production. P. also intermediate host of Angiostrongylus cantonensis, which human eosinophilic meningitis. In this study, the molluscicidal activity and safety profile a novel molluscicide PBQ [1-(4-chlorophenyl)-3-(pyridin-3-yl)urea] were evaluated. exhibited strong potency against adult juvenile snails (LC50 values 0.39 0.07 mg/L, respectively). field trials, killed 99.42% at 0.25 g...
Background The global gene expression profiles of adult and fetal murine prostate stem cells were determined to define common unique regulators whose misexpression might play a role in the development cancer. Methodology/Principal Findings A distinctive core transcriptional both primitive was identified as well molecules that are exclusive each population. Elements include Wnt, Shh other pathways organs, signatures aryl-hydrocarbon receptor, up-regulation components aldehyde...
A simple and sensitive enantioselective method for the determination of fenbuconazole myclobutanil in strawberry was developed by high-performance liquid chromatography–tandem mass spectrometry (HPLC-MS/MS). Fenbuconazole residues were extracted with acetonitrile containing 1% acetic acid, an aliquot cleaned up PSA (primary secondary amine) C18 sorbent. The direct resolution enantiomers performed on a cellulose tris (3,5-dimethylphenylcarbamate) column using acetonitrile–0.1% formic acid...
Abstract The enantioselective degradation of tebuconazole has been investigated to elucidate the behaviors in agricultural soils, cabbage, and cucumber fruit. Rac ‐tebuconazole was fortified into three types soils sprayed foliage cabbage cucumber, respectively. kinetics, enantiomer fraction enantiomeric selectivity were determined by reverse‐phase high‐performance liquid chromatography (HPLC) chromatography‐mass spectrometry/mass spectrometry (LC‐MS/MS) on a Lux amylose‐2 chiral column....
The enantiomeric separation of 21 triazole fungicides was carried out on four polysaccharide‐derived chiral stationary phases in the reversed phase mode using high performance liquid chromatography coupled with tandem mass spectrometry. All were detected electrospray ionization ( ESI ) positive selected reaction monitoring SRM ). Complete enantioseparation achieved for except difenoconazole based cellulose tris (3,5‐dimethylphenylcarbamate) and (3‐chloro‐4‐methylphenyl carbamate) columns by...
Exploring the migration behaviors of selenium in granite is critical for safe disposal radioactive waste. The matrix diffusion and sorption 75Se(IV) (analogue 79Se) were systematically studied to set reliable parameters this work. Through-diffusion batch experiments conduct with four types Beishan granite. magnitudes obtained apparent coefficient (Da) values are following order: monzogranite > granodiorite-2 granodiorite-1, which opposite sequence Kd from both model experiments. EPMA results...
The rizoma of Pulsatilla chinensis (Bunge) Regel has been used as a traditional Chinese medicinal herb for thousands years. Total saponins from P. can induce the apoptosis solid cancer cells; however, their activity on chronic myeloid leukemia and mechanisms remains unknown.To study total main active fractions leukemia, to illustrate underlying anticancer activities.The cytotoxic were assayed by MTT; cell cycle arrest tested flow cytometry system; changes in mitochondrial membrane potential...